Aspen Lung Conference: Bridging the Gap between Innate and Adaptive Immunity in the Lung

阿斯彭肺部会议：弥合肺部先天免疫和适应性免疫之间的差距

• 批准号: 10469141
• 负责人: William Janssen
• 金额: $ 3.3万
• 依托单位: NATIONAL JEWISH HEALTH
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10469141
• 关键词: Address; Autoimmune; Autoimmunity; Award; Basic Science; Biology; Chronic lung disease; Clinical; Clinical Research; Dedications; Development; Disease; Ethnic group; Exposure to; Faculty; Future; Generations; Grant; Immune system; Immunologics; Infectious Agent; International; Knowledge; Lead; Lung; Lung diseases; Measures; Mediating; Mentorship; Minority; Mononuclear; Natural Immunity; Oral; Pathogenesis; Patients; Phagocytes; Prevalence; Publishing; Research; Research Personnel; Role; Scientific Advances and Accomplishments; Scientist; Series; Translating; Translational Research; Translations; Travel; Underrepresented Minority; Woman; adaptive immune response; adaptive immunity; base; cancer therapy; career; coronavirus disease; diversity and inclusion; environmental agent; host-microbe interactions; improved; inflammatory lung disease; interest; lectures; lung health; novel; novel strategies; posters; pre-clinical; programs; public health relevance; racial and ethnic; success; symposium

PROJECT SUMMARY/ABSTRACT With an emphasis on the integration of basic, translational, and clinical approaches, the 64th annual Aspen Lung Conference will focus on a central question: how can knowledge of the immunologic mechanisms that underlie lung disease enhance our understanding of disease development and be translated into effective approaches to treat lung disease? To address this central question, the program is organized into a series of thematic sessions, with State of the Art speakers framing the topic. The thematic sessions will focus on (i) the role of innate immunity via mononuclear phagocytes and its impact on inflammatory lung disease, (ii) bridging the gap between the innate and adaptive immune responses in the lung focusing on the host-microbe interactions, (iii) evaluating the interface between the innate and adaptive immune response in COVID and other lung diseases, (iv) the role of adaptive immunity in the development of autoimmunity and autoimmune lung disease, (v) understanding lessons learned from immunologic cancer treatments and approaches, and (vi) defining future treatment options to harness the immune system for generation of novel. By addressing these topics, we seek to accomplish the following: 1) provide an international forum for leading basic, translational, and clinical researchers to exchange ideas regarding the role of the immune system in the development and progression of chronic lung disease; 2) stimulate interactions between scientific fields to identify emerging and shared interests that may lead to more efficient and productive research; 3) enhance the likelihood of success in translation of preclinical scientific advances into direct patient benefit by developing novel strategies to better understand disease pathogenesis and implement scientific advances in treatment of chronic lung diseases; and 4) challenge and stimulate the scientific interests of trainees and attract a new generation of junior investigators into the field of innate and adaptive immunity in the lung. We have identified 12 outstanding thought leaders to present State of the Art lectures (35 min) on these topics. Each presentation will be followed by 25 minutes of discussion - a hallmark of the Conference. The program continues the Aspen Lung Conference’s dedication to diversity and inclusivity: n=6/13 (54%) of State of the Art speakers/Summarizer are women, and at least 6 of our speakers are from underrepresented racial/ethnic groups. Participation of trainees and junior faculty is facilitated by two 15-minute oral abstracts, selected from submitted abstracts, following each State of the Art speaker (24 total). There will be two evening poster sessions for further presentation opportunities by junior faculty and trainees. The final presentation is provided by a Conference Summarizer, who reviews the impact and common themes of the Conference. The Conference Summary will be published for widespread dissemination, to serve as a “think tank” that not only summarizes the current state of the field, but also identifies key future directions for basic, translation, and clinical research. Finally, and notably, registration for the Aspen Lung Conference is free, encouraging participation from a wide spectrum of trainees and early career investigators.

项目总结/摘要 第64届年度白杨肺学会强调基础、转化和临床方法的整合， 会议将集中讨论一个中心问题：如何了解免疫机制， 肺部疾病的基础增强我们对疾病发展的理解，并转化为 治疗肺部疾病的有效方法？为了解决这个核心问题，该计划被组织成 一系列主题会议，由最新技术演讲者阐述主题。专题会议将侧重于 （i）通过单核吞噬细胞的先天免疫的作用及其对炎性肺病的影响，（ii） 弥合肺部先天性和适应性免疫应答之间的差距，重点关注宿主微生物 相互作用，（iii）评估COVID和其他疾病中先天性和适应性免疫反应之间的界面 肺部疾病，（iv）适应性免疫在自身免疫和自身免疫性肺部疾病发展中的作用 疾病，（v）了解从免疫癌症治疗和方法中吸取的经验教训，以及（vi） 确定未来的治疗方案，以利用免疫系统产生新的。通过解决这些 主题，我们寻求实现以下目标：1）为领导基础、翻译和 临床研究人员就免疫系统在发展中的作用交换意见， 慢性肺部疾病的进展; 2）刺激科学领域之间的互动，以确定新兴的， 共同的兴趣，可能会导致更有效和更富有成效的研究; 3）提高成功的可能性 通过开发新的策略，将临床前科学进展转化为直接的患者受益， 了解疾病的发病机制，并在慢性肺部疾病的治疗中实施科学进步;以及 4)挑战和激发受训人员的科学兴趣，吸引新一代的初级调查人员 肺的先天免疫和适应性免疫领域。我们已经确定了12位杰出的思想领袖， 目前的最先进的讲座（35分钟）对这些主题。每次演讲后将有25分钟的 讨论-裁谈会的一个标志。该计划延续了白杨肺部会议的奉献精神， 多样性和包容性：n=6/13（54%）的最新技术演讲者/总结者是女性，其中至少有6人是女性 发言者来自代表性不足的种族/族裔群体。促进学员和初级教员的参与 从提交的摘要中选出两篇15分钟的口头摘要，在每位最新技术演讲者（24 共计）。将有两个晚上的海报会议，进一步介绍机会，由初级教师和 实习生最后的演讲由会议总结者提供，他回顾了会议的影响和共同点。 会议的主题。会议摘要将予以公布，以广泛传播， 作为一个“智囊团”，不仅总结了该领域的现状，而且还确定了未来的主要方向 用于基础、翻译和临床研究。最后，值得注意的是，白杨肺部会议的注册是 免费，鼓励广泛的学员和早期职业调查人员参与。