Aspen Lung Conference: Bridging the Gap between Innate and Adaptive Immunity in the Lung

阿斯彭肺部会议：弥合肺部先天免疫和适应性免疫之间的差距

• 批准号: 10469141
• 负责人: William Janssen
• 金额: $ 3.3万
• 依托单位: NATIONAL JEWISH HEALTH
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10469141
• 关键词: Address; Autoimmune; Autoimmunity; Award; Basic Science; Biology; Chronic lung disease; Clinical; Clinical Research; Dedications; Development; Disease; Ethnic group; Exposure to; Faculty; Future; Generations; Grant; Immune system; Immunologics; Infectious Agent; International; Knowledge; Lead; Lung; Lung diseases; Measures; Mediating; Mentorship; Minority; Mononuclear; Natural Immunity; Oral; Pathogenesis; Patients; Phagocytes; Prevalence; Publishing; Research; Research Personnel; Role; Scientific Advances and Accomplishments; Scientist; Series; Translating; Translational Research; Translations; Travel; Underrepresented Minority; Woman; adaptive immune response; adaptive immunity; base; cancer therapy; career; coronavirus disease; diversity and inclusion; environmental agent; host-microbe interactions; improved; inflammatory lung disease; interest; lectures; lung health; novel; novel strategies; posters; pre-clinical; programs; public health relevance; racial and ethnic; success; symposium

PROJECT SUMMARY/ABSTRACT With an emphasis on the integration of basic, translational, and clinical approaches, the 64th annual Aspen Lung Conference will focus on a central question: how can knowledge of the immunologic mechanisms that underlie lung disease enhance our understanding of disease development and be translated into effective approaches to treat lung disease? To address this central question, the program is organized into a series of thematic sessions, with State of the Art speakers framing the topic. The thematic sessions will focus on (i) the role of innate immunity via mononuclear phagocytes and its impact on inflammatory lung disease, (ii) bridging the gap between the innate and adaptive immune responses in the lung focusing on the host-microbe interactions, (iii) evaluating the interface between the innate and adaptive immune response in COVID and other lung diseases, (iv) the role of adaptive immunity in the development of autoimmunity and autoimmune lung disease, (v) understanding lessons learned from immunologic cancer treatments and approaches, and (vi) defining future treatment options to harness the immune system for generation of novel. By addressing these topics, we seek to accomplish the following: 1) provide an international forum for leading basic, translational, and clinical researchers to exchange ideas regarding the role of the immune system in the development and progression of chronic lung disease; 2) stimulate interactions between scientific fields to identify emerging and shared interests that may lead to more efficient and productive research; 3) enhance the likelihood of success in translation of preclinical scientific advances into direct patient benefit by developing novel strategies to better understand disease pathogenesis and implement scientific advances in treatment of chronic lung diseases; and 4) challenge and stimulate the scientific interests of trainees and attract a new generation of junior investigators into the field of innate and adaptive immunity in the lung. We have identified 12 outstanding thought leaders to present State of the Art lectures (35 min) on these topics. Each presentation will be followed by 25 minutes of discussion - a hallmark of the Conference. The program continues the Aspen Lung Conference’s dedication to diversity and inclusivity: n=6/13 (54%) of State of the Art speakers/Summarizer are women, and at least 6 of our speakers are from underrepresented racial/ethnic groups. Participation of trainees and junior faculty is facilitated by two 15-minute oral abstracts, selected from submitted abstracts, following each State of the Art speaker (24 total). There will be two evening poster sessions for further presentation opportunities by junior faculty and trainees. The final presentation is provided by a Conference Summarizer, who reviews the impact and common themes of the Conference. The Conference Summary will be published for widespread dissemination, to serve as a “think tank” that not only summarizes the current state of the field, but also identifies key future directions for basic, translation, and clinical research. Finally, and notably, registration for the Aspen Lung Conference is free, encouraging participation from a wide spectrum of trainees and early career investigators.

项目摘要/摘要 重点是基本，翻译和临床方法的整合，第64届年度阿斯彭肺 会议将重点介绍一个核心问题：如何了解免疫机制 肺部疾病的基础增强了我们对疾病发展的理解，并被转化为 有效治疗肺部疾病的方法？为了解决这个核心问题，该程序被组织到 一系列主题会议，最先进的演讲者构建了主题。主题会议将集中 （i）通过单核吞噬细胞及其对炎症性肺部疾病的影响，先天免疫的作用，（ii） 在肺中弥合先天性和适应性免疫调查的差距，重点是宿主菌 相互作用，（iii）评估既有的和其他人之间的界面和适应性免疫响应 肺部疾病，（iv）自适应免疫组织化学在自身免疫和自身免疫肺的发展中的作用 疾病，（v）了解从免疫癌症治疗和方法中学到的经验教训，以及（vi） 定义未来的治疗选择，以利用免疫系统的产生。通过解决这些问题 主题，我们试图完成以下任务：1）为领先，翻译和领先的国际论坛提供一个国际论坛 临床研究人员交换有关免疫系统在开发中的作用的想法 慢性肺部疾病的进展； 2）刺激科学领域之间的相互作用，以识别新兴和 共同的利益可能会导致更有效和产品研究； 3）增强成功的可能性 通过制定新颖的策略来改善临床前科学进步转化为直接患者福利 了解疾病发病机理并在慢性肺部疾病治疗方面的科学进步；和 4）挑战和刺激学员的科学利益，并吸引新一代的初级调查员 进入肺部先天和适应性免疫的领域。我们已经确定了12位杰出的思想领袖 当前关于这些主题的艺术演讲（35分钟）。每个演示文稿将随后25分钟 讨论 - 会议的标志。该计划继续进行阿斯彭肺会议的奉献精神 多样性和包容性：n = 6/13（54％）的艺术扬声器/摘要者是女性，我们至少有6个 演讲者来自代表性不足的种族/族裔群体。准备学员和初级教师的参与 由两个15分钟的口头摘要，从提交的摘要中选择，遵循每个先进的演讲者（24 将会有两个晚上的海报会议，以供初级教职员工进一步演讲 学员。最终演示由会议摘要提供了，他审查了影响和共同的影响 会议的主题。会议摘要将出版以进行宽度传播，以服务 作为一个“智囊团”，不仅总结了该领域的当前状态，而且还标识了未来的关键方向 用于基础，翻译和临床研究。最后，值得注意的是，阿斯彭肺会议的注册是 自由，鼓励各种各样的学员和早期职业调查员的参与。