权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Mentoring in Advanced mHealth Technologies and Machine Learning for HIV/Drug Abuse Research

指导艾滋病毒/药物滥用研究的先进移动医疗技术和机器学习

基本信息

批准号：
10469618
负责人：
Edward W Boyer
金额：
$ 19.13万
依托单位：
OHIO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-11-19 至 2026-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10469618
关键词：
Accelerometer Acute Pain Address Adherence Adopted Adult Affect Affective Anti-Retroviral Agents Area Artificial Intelligence Award Behavior Behavior Therapy Behavioral Biosensing Techniques Biosensor Brain COVID-19 COVID-19 diagnosis Cannabis Capital Caring Cellular Phone Collection Communicable Diseases Computers Contracts Data Data Collection Development Devices Diagnosis Discipline Discrimination Drug abuse Drug usage Electrical Engineering Exhalation Funding General Population Goals HIV Health Healthcare Human Imagery Individual Ingestion Inhalation Institutional Review Boards Intellectual Property Interdisciplinary Study Interruption Intervention Investigation Learning Life Machine Learning Malaysia Maps Measures Medical Mental Depression Mentors Methods Mid-Career Clinical Scientist Award (K24)Midcareer Investigator Award in Patient-Oriented Research Minority Mission Music National Institute of Drug Abuse Nociception Opioid Pathway interactions Patient Care Patients Pattern Penetrance Persons Pharmaceutical Preparations Phenotype Play Population Populations at Risk Principal Investigator Process Property Rights Research Research Personnel Research Project Grants Rewards Risk Behaviors Role SARS-CoV-2 infection Scholarship Scientist Self Management Source Substance Use Disorder Substance abuse problem Techniques Technology Telephone Temperature Testing Text Messaging Time United States National Institutes of Health Virus Diseases Woman Wrist antiretroviral therapy base career career development cohort commercialization comorbidity design detector digital experience health care availability health care disparity improved innovation interest mHealth magnetic field medication compliance mobile computing nasal swab neurotransmission next generation novel opiate tolerance opioid use personal protective equipment pill programs response skills social stigma socioeconomics substance abuse prevention substance abuse treatment success theories therapy adherence therapy development wearable sensor technology

项目摘要

Abstract Renewal of my Midcareer Investigator Award in Patient-Oriented Research (K24) will allow me to continue my strong efforts directed toward successful original investigations and mentoring to generate research capacity in mobile technologies to improve health (mHealth). The impact of the initial K24 on my mentees has been striking. Since award of the initial K24, nearly two dozen of my mentees, 70% of whom are women or minorities, have been PI on NIH funded studies (under K, R, or Loan Repayment Program mechanisms). The impact the K24 on my own research has been substantial. Since 2014, I have been Principal Investigator (PI) on six federally funded awards: 1) one newly funded 4-year R01 from NIDA; 2) one R56 from NIDA; 3) one two-year R01 from NIDA; 4) one 4-year R01 from NIDA; 5) my K24 from NIDA; and 6) one newly funded 4-year DARPA research award. In addition, I received a William J Fulbright Foreign Scholarship to Malaysia. As my K24 evolved, so has my research focus. My overall research objective is to devote sufficient time to investigate use of next generation (“NextGen”) technologies, invisible biosensing, and machine learning in substance abuse and HIV research. My first research project, Virya, uses “digital phenotyping” with invisible biosensing and machine learning, to identify acute pain exacerbations in HIV+ individuals on opioids, a population at risk for problematic opioid use. The second reseach project uses mobile technologies to diagnose Covid-19 infection in HIV+ persons who inhale cannabis, itself a high-impact topic. Finally, the R01-funded MyTPill project compares the NextGen technology of unobtrusive ingestible biosensors that provide vivid, indisputable measures of medication ingestion. NextGen research discoveries become commercial products, but this process of introducing new discoveries into the healthcare economy remains deeply unfamiliar—yet increasingly important— to academic clinician-scientists. The objective of my Career Development Activities, therefore, involves learning how to navigate regulatory processes, FDA approvals, valuations, venture capital, contracts and intellectual property rights. Because of the growing importance of commercialization of research findings to the health and sustainability of academic careers, my overall mentoring objective of this K24 is to develop researchers who not only have the skills to conduct rigorous NextGen mHealth studies, but also to extend the mass of NIH-funded mHealth research into the healthcare economy. My mentoring approach incorporates several components that contributed to the success of my initial K24: dedicated funding for mentee’s early investigations; outstanding institutional support; several sources of referral of high-quality mentees; and renowned co- mentors who will help me establish a pipeline of mentees that have risen to that “cutting edge” where successful academic careers begin. This proposed K24 renewal, with its focus on NextGen technologies, invisible biosensing, and machine learning, is highly relevant to NIH’s mission because the lessons learned from this substance abuse and HIV research are directly applicable to the care of patients with common, intractable, and expensive conditions.

摘要