Mentoring in advanced mHealth interventions for drug abuse and HAART adherence

描述（由申请人提供）：这个K24建议建立在我成功的指导和原始调查的良好记录，以产生在移动的技术领域的研究能力，以改善健康（mHealth）。我指导了21名临床科学家，其中15人获得了K23，K08，R01，R21，R03，贷款偿还计划和少数民族补充机制下的NIH资金。在我目前指导的16位临床科学家中，有12位从事与移动健康相关的研究。我在马萨诸塞州大学（UMass）CTSA资助的辅导项目中的职责、我与NIDA资助的达特茅斯医学院P30技术和行为健康中心的合作、NIDA项目工作人员的推荐以及其他工作扩大了我的指导范围，并确保了全国范围内的学员来源。我以患者为导向的研究重点是mHealth方法来治疗药物滥用和提高艾滋病毒感染者的药物依从性。移动的技术的使用显著增加，为在最需要的时间和地点在自然环境中提供卫生干预措施创造了巨大的机会。尽管移动的技术具有广泛的覆盖范围、多媒体功能和计算能力，但有几个特征威胁到智能手机提供的行为干预的可接受性，并减损其作为有效健康促进工具的巨大潜力。因此，本提案的最终目标是创造能够产生持久有益健康影响的移动的技术驱动的干预措施。K24的总体研究目标是通过三个协同研究重点开发新的移动健康行为干预措施。第一个是开发先进的移动健康行为干预措施，支持长期禁欲，预防复发，并促进艾滋病毒+患者的抗逆转录病毒治疗依从性。第二个涉及开发移动的生物传感方法，通过确定吸毒发作的开始和持续时间，评估这些高度创新的干预措施的有效性。在第三条调查路线中，我打算阐明设计元素， 将最大限度地提高新型移动健康行为干预的可用性和可接受性。K24的总体指导目标是培养研究人员，他们不仅具有开发，实施和发布假设驱动，以患者为导向的移动健康研究的技能，而且了解将多方法，多学科方法应用于临床和转化研究问题的重要性。我的指导方法强调根据感兴趣的问题的性质定制研究方法的重要性，即使这意味着学习新的行为科学，工程和临床研究方法，或者与熟悉这些方法的其他学科的研究人员进行合作。拟议的研究与NIH的使命相关，因为从药物滥用和HIV相关工作中吸取的经验教训可直接应用于其他常见，棘手和昂贵的条件下接受行为干预的患者的护理。

DESCRIPTION (provided by applicant): This K24 proposal builds on my strong record of successful mentoring and original investigation to generate research capacity in the area of mobile technologies to improve health (mHealth). I have mentored 21 clinician-scientists, 15 of whom have been awarded NIH funding under K23, K08, R01, R21, R03, Loan Repayment Program, and Minority Supplement mechanisms. Of the 16 clinician-scientists whom I currently mentor, 12 have engaged in mHealth-related research. My responsibilities in the University of Massachusetts (UMass) CTSA-funded mentoring programs, my collaborations with the NIDA-funded P30 Center for Technology and Behavioral Health at Dartmouth Medical School, referrals from NIDA program staff, and other efforts have expanded the scope of my mentoring and ensured a nationwide source of mentees. My patient-oriented research focuses on mHealth approaches to substance abuse treatment and improving medication adherence in persons with HIV. The striking increase in the use of mobile technologies has created great opportunities for delivery of health interventions in natural environments at the time and location they are needed most. Despite the broad reach, multimedia capabilities, and computing power of mobile technologies, several features threaten the acceptability of smartphone-delivered behavioral interventions and detract from their enormous potential as effective health promotion tools. The ultimate goal of this proposal, therefore, is to create mobile technology-driven interventions capable of producing persistent beneficial health effects. The overall research goal of the K24 is to develop new classes of mHealth behavioral interventions through three synergistic research thrusts. The first involves the development of advanced mHealth behavioral interventions that support long-term abstinence, prevent relapse, and promote antiretroviral adherence in HIV+ patients. The second involves development of mobile biosensing methods that can assess the effectiveness of these highly innovative interventions by identifying the onset and duration of drug use episodes. In a third line of investigation, I intend to elucidate the design elements that will maximize the usability and acceptability of novel mHealth behavioral interventions. The overall mentoring objective of this K24 is to develop researchers who not only have the skills to develop, implement, and publish hypothesis driven, patient-oriented mHealth research, but who understand the importance of bringing a multi-method, multi-disciplinary approach to clinical and translational research problems. My mentoring approach emphasizes the importance of tailoring research methods to the nature of the problem of interest, even if that means learning new behavioral science, engineering, and clinical research methods or developing collaborations with investigators from other disciplines familiar with those methods. The proposed research is relevant to the NIH's mission because the lessons learned from this drug abuse- and HIV-related work are directly applicable to the care of patients with other common, intractable, and expensive conditions amenable to behavioral interventions.