Mentoring in advanced mHealth interventions for drug abuse and HAART adherence

描述（由申请人提供）：这个K24提案建立在我在移动技术改善健康（mHealth）领域的成功指导和原始调查的强大记录之上。我指导过21名临床科学家，其中15人获得了NIH资助，包括K23、K08、R01、R21、R03、贷款偿还计划和少数民族补充机制。在我目前指导的16位临床科学家中，有12位从事与移动健康相关的研究。我在马萨诸塞大学ctsa资助的指导项目中的职责，我与NIDA资助的达特茅斯医学院P30技术和行为健康中心的合作，NIDA项目工作人员的推荐，以及其他努力扩大了我指导的范围，并确保了全国范围内的学员来源。我的病人为导向的研究侧重于移动医疗方法药物滥用治疗和改善药物依从性的人与艾滋病毒。移动技术使用的显著增加为在最需要的时间和地点在自然环境中提供卫生干预措施创造了巨大的机会。尽管移动技术具有广泛的覆盖范围、多媒体功能和计算能力，但一些特征威胁到智能手机提供的行为干预的可接受性，并削弱了它们作为有效健康促进工具的巨大潜力。因此，本提案的最终目标是创建能够产生持久有益健康影响的移动技术驱动的干预措施。K24的总体研究目标是通过三个协同研究重点开发新的移动健康行为干预类别。第一项涉及开发先进的移动健康行为干预措施，支持长期禁欲，防止复发，并促进艾滋病毒阳性患者坚持抗逆转录病毒治疗。第二个涉及开发移动生物传感方法，通过识别药物使用发作的开始和持续时间来评估这些高度创新的干预措施的有效性。在调查的第三条线中，我打算阐明的设计元素

DESCRIPTION (provided by applicant): This K24 proposal builds on my strong record of successful mentoring and original investigation to generate research capacity in the area of mobile technologies to improve health (mHealth). I have mentored 21 clinician-scientists, 15 of whom have been awarded NIH funding under K23, K08, R01, R21, R03, Loan Repayment Program, and Minority Supplement mechanisms. Of the 16 clinician-scientists whom I currently mentor, 12 have engaged in mHealth-related research. My responsibilities in the University of Massachusetts (UMass) CTSA-funded mentoring programs, my collaborations with the NIDA-funded P30 Center for Technology and Behavioral Health at Dartmouth Medical School, referrals from NIDA program staff, and other efforts have expanded the scope of my mentoring and ensured a nationwide source of mentees. My patient-oriented research focuses on mHealth approaches to substance abuse treatment and improving medication adherence in persons with HIV. The striking increase in the use of mobile technologies has created great opportunities for delivery of health interventions in natural environments at the time and location they are needed most. Despite the broad reach, multimedia capabilities, and computing power of mobile technologies, several features threaten the acceptability of smartphone-delivered behavioral interventions and detract from their enormous potential as effective health promotion tools. The ultimate goal of this proposal, therefore, is to create mobile technology-driven interventions capable of producing persistent beneficial health effects. The overall research goal of the K24 is to develop new classes of mHealth behavioral interventions through three synergistic research thrusts. The first involves the development of advanced mHealth behavioral interventions that support long-term abstinence, prevent relapse, and promote antiretroviral adherence in HIV+ patients. The second involves development of mobile biosensing methods that can assess the effectiveness of these highly innovative interventions by identifying the onset and duration of drug use episodes. In a third line of investigation, I intend to elucidate the design elements that will maximize the usability and acceptability of novel mHealth behavioral interventions. The overall mentoring objective of this K24 is to develop researchers who not only have the skills to develop, implement, and publish hypothesis driven, patient-oriented mHealth research, but who understand the importance of bringing a multi-method, multi-disciplinary approach to clinical and translational research problems. My mentoring approach emphasizes the importance of tailoring research methods to the nature of the problem of interest, even if that means learning new behavioral science, engineering, and clinical research methods or developing collaborations with investigators from other disciplines familiar with those methods. The proposed research is relevant to the NIH's mission because the lessons learned from this drug abuse- and HIV-related work are directly applicable to the care of patients with other common, intractable, and expensive conditions amenable to behavioral interventions.