Mentoring in advanced mHealth interventions for drug abuse and HAART adherence

描述(由申请人提供)：这份K24计划建立在我成功指导和原始调查的良好记录基础上，以产生移动技术领域的研究能力，以改善健康(MHealth)。我已经指导了21名临床科学家，其中15人在K23、K08、R01、R21、R03、贷款偿还计划和少数民族补充机制下获得了NIH资金。在我目前指导的16名临床医生科学家中，有12人从事了与移动健康相关的研究。我在马萨诸塞大学CTSA资助的指导项目中的责任，我与NIDA资助的达特茅斯医学院P30技术和行为健康中心的合作，NIDA项目工作人员的推荐，以及其他努力扩大了我的指导范围，并确保了全国范围内的指导对象来源。我以患者为中心的研究重点是mHealth治疗药物滥用的方法和改善艾滋病毒携带者的用药依从性。移动技术的使用显著增加，为在最需要的时间和地点在自然环境中提供卫生干预措施创造了巨大的机会。尽管移动技术具有广泛的覆盖面、多媒体功能和计算能力，但有几个功能威胁到智能手机提供的行为干预的可接受性，并削弱了它们作为有效健康促进工具的巨大潜力。因此，这项提议的最终目标是创造能够产生持久有益健康影响的移动技术驱动的干预措施。K24的总体研究目标是通过三个协同研究推力开发新的mHealth行为干预类别。第一个涉及开发先进的mHealth行为干预措施，支持艾滋病毒患者的长期禁欲，防止复发，并促进抗逆转录病毒的坚持。第二个涉及开发移动生物传感方法，通过确定吸毒发作的开始和持续时间来评估这些高度创新的干预措施的有效性。在第三条调查中，我打算阐明以下设计元素 将最大限度地提高新型mHealth行为干预的可用性和可接受性。这本K24课程的总体指导目标是培养研究人员，他们不仅拥有开发、实施和发表假说驱动的、以患者为导向的mHealth研究的技能，而且了解将多方法、多学科方法引入临床和翻译研究问题的重要性。我的指导方法强调了根据感兴趣的问题的性质定制研究方法的重要性，即使这意味着学习新的行为科学、工程学和临床研究方法，或者与熟悉这些方法的其他学科的研究人员发展合作。这项拟议的研究与NIH的任务相关，因为从这项与药物滥用和艾滋病毒相关的工作中吸取的经验教训直接适用于患有其他常见、棘手和昂贵的疾病的患者的护理，这些患者可以接受行为干预。

DESCRIPTION (provided by applicant): This K24 proposal builds on my strong record of successful mentoring and original investigation to generate research capacity in the area of mobile technologies to improve health (mHealth). I have mentored 21 clinician-scientists, 15 of whom have been awarded NIH funding under K23, K08, R01, R21, R03, Loan Repayment Program, and Minority Supplement mechanisms. Of the 16 clinician-scientists whom I currently mentor, 12 have engaged in mHealth-related research. My responsibilities in the University of Massachusetts (UMass) CTSA-funded mentoring programs, my collaborations with the NIDA-funded P30 Center for Technology and Behavioral Health at Dartmouth Medical School, referrals from NIDA program staff, and other efforts have expanded the scope of my mentoring and ensured a nationwide source of mentees. My patient-oriented research focuses on mHealth approaches to substance abuse treatment and improving medication adherence in persons with HIV. The striking increase in the use of mobile technologies has created great opportunities for delivery of health interventions in natural environments at the time and location they are needed most. Despite the broad reach, multimedia capabilities, and computing power of mobile technologies, several features threaten the acceptability of smartphone-delivered behavioral interventions and detract from their enormous potential as effective health promotion tools. The ultimate goal of this proposal, therefore, is to create mobile technology-driven interventions capable of producing persistent beneficial health effects. The overall research goal of the K24 is to develop new classes of mHealth behavioral interventions through three synergistic research thrusts. The first involves the development of advanced mHealth behavioral interventions that support long-term abstinence, prevent relapse, and promote antiretroviral adherence in HIV+ patients. The second involves development of mobile biosensing methods that can assess the effectiveness of these highly innovative interventions by identifying the onset and duration of drug use episodes. In a third line of investigation, I intend to elucidate the design elements that will maximize the usability and acceptability of novel mHealth behavioral interventions. The overall mentoring objective of this K24 is to develop researchers who not only have the skills to develop, implement, and publish hypothesis driven, patient-oriented mHealth research, but who understand the importance of bringing a multi-method, multi-disciplinary approach to clinical and translational research problems. My mentoring approach emphasizes the importance of tailoring research methods to the nature of the problem of interest, even if that means learning new behavioral science, engineering, and clinical research methods or developing collaborations with investigators from other disciplines familiar with those methods. The proposed research is relevant to the NIH's mission because the lessons learned from this drug abuse- and HIV-related work are directly applicable to the care of patients with other common, intractable, and expensive conditions amenable to behavioral interventions.