Mentoring in Endocrine and Cardiometabolic Abnormalities in Cancer and Aging

项目摘要 Shehzad Basaria，医学博士，内分泌科医学和内分泌学副教授， 哈佛医学院布里格姆妇女医院糖尿病与代谢科提交此申请 获得K24中期职业发展奖，以提供受保护的时间来指导学员以患者为导向 研究（POR）在老年肿瘤学的内分泌方面。巴萨利亚医生是为数不多的 专门研究患有癌症和雄激素的老年男性的内分泌和心脏代谢疾病 缺陷他将继续接受额外的培训，以磨练他的指导技能， 导师的记录，并促进早期研究人员的研究生涯。 候选人：Basaria博士是内分泌学，衰老和 癌自2003年以来，他一直受到NIH的资助，研究：i）内分泌和心脏代谢 前列腺癌（PCa）男性雄激素剥夺治疗（ADT）的并发症，ii）获益和风险 雄激素替代老年男性，和iii）衰老的内分泌学。他进行了调查 使用NIH支持的基础设施，包括RO 1和R21赠款，来自巴尔的摩纵向研究的数据 老化研究（BLSA），InChianti研究和波士顿胡椒功能促进治疗中心。 凭借他在内分泌学和老年肿瘤学方面的非凡技能和强大的POR计划，他一直是一位 在布里格姆/哈佛和国家和国际机构的抢手的合作者和导师。 指导计划/环境：此应用程序将利用 布里格姆/哈佛，包括临床研究中心，布里格姆临床研究所和 转化研究和T32培训赠款在各种专业。它还将利用无与伦比的 波士顿胡椒中心和其他资助研究的资源，作为POR学员的平台， 多层次的 研究计划：K24奖支持的新研究将为 1A） ADT诱导的严重性腺功能减退和由此导致的肌肉质量下降对身体功能的影响， 1B）ADT对骨骼肌的脂肪浸润的影响以及这种肌肉退化的关联 身体功能的质量，和2）睾酮替代改善癌症的机制- 老年男性癌症患者的相关疲劳。 了解雄激素缺乏对老年男性癌症患者在三个主要领域的影响： 这些新的目标将建立在Basaria博士正在进行的工作的基础上。 当前的R 01，探索新的假设，并扩大学员的机会。

PROJECT SUMMARY Shehzad Basaria, MD, an Associate Professor of Medicine and Endocrinology in the Division of Endocrinology, Diabetes, & Metabolism at Brigham and Women's Hospital, Harvard Medical School, submits this application for a K24 Mid-Career Development award to provide protected time to mentor trainees in Patient-Oriented Research (POR) in Endocrine aspects of Gero-Oncology. Dr. Basaria is one of the few endocrinologists worldwide specializing in endocrine and cardio-metabolic disorders in older men with cancer and androgen deficiency. He will pursue additional training to hone his mentoring skills in order to build on his established record of mentorship and foster the research careers of early investigators. Candidate: Dr. Basaria is a highly productive clinical researcher in the field of Endocrinology, Aging and Cancer. Since 2003, he has been continuously NIH-funded to investigate: i) endocrine and cardio-metabolic complications of androgen deprivation therapy (ADT) in men with prostate cancer (PCa), ii) benefits and risks of androgen replacement in older men, and iii) endocrinology of aging. He has conducted his investigations using NIH-supported infrastructure, including RO1s and R21 grants, data from the Baltimore Longitudinal Study of Aging (BLSA), the InChianti Study, and the Boston Pepper Center for Function-Promoting Therapies. With his uncommon skill set and strong POR program in Endocrinology and Gero-Oncology, he has been a sought-after collaborator and mentor at Brigham/Harvard and at national and international institutions. Mentoring Plan/Environment: This application will leverage the extensive training resources at Brigham/Harvard, including the Center for Clinical Investigation, the Brigham Research Institute for Clinical and Translational Research, and T32 training grants in a variety of specialties. It will also draw on the unparalleled resources of the Boston Pepper Center and other funded studies to serve as a platform for POR trainees at multiple levels. Research Plan: The novel research supported by this K24 award will make significant contributions to the 1A) The impact of ADT-induced profound hypogonadism and the resulting decline in muscle mass on physical function, 1B) The impact of ADT on fat infiltration of skeletal muscles and the association of this deterioration in muscle quality on physical function, and 2) The mechanisms by which testosterone replacement improves Cancer- Related Fatigue in older men with cancer. understanding of the impact of androgen deficiency in older men with cancer in three major areas: These novel aims will build on the ongoing work in Dr. Basaria's current R01s, explore new hypotheses, and expand opportunities for trainees.