Mentoring in Endocrine and Cardiometabolic Abnormalities in Cancer and Aging

项目总结 Shehzad Basaria医学博士，内分泌科医学和内分泌学副教授， 哈佛医学院布里格姆妇女医院的糖尿病和新陈代谢提交本申请 获得K24中期职业发展奖，为学员提供以患者为导向的指导时间 老年肿瘤学内分泌研究(POR)。巴萨里亚医生是为数不多的内分泌学家之一 世界各地专门研究患有癌症和雄激素的老年男性的内分泌和心脏代谢紊乱 缺乏症。他将继续接受额外的培训，以磨练他的指导技能，以便在他已建立的基础上再接再厉 指导记录和促进早期研究人员的研究事业。 候选人：巴萨里亚博士是内分泌学、老年学和医学领域的一位高产的临床研究人员。 癌症。自2003年以来，他一直得到美国国立卫生研究院的资助，从事以下研究：i)内分泌和心脏代谢 前列腺癌患者雄激素剥夺治疗(ADT)的并发症(II)益处和风险 老年男性的雄激素替代，以及iii)衰老的内分泌学。他已经进行了调查 使用NIH支持的基础设施，包括RO1和R21赠款，来自巴尔的摩纵向 老龄化研究(BLSA)、Inchianti研究和波士顿胡椒功能促进疗法中心。 凭借其非凡的技能和强大的内分泌学和老年肿瘤学POR计划，他一直是一名 在布里格姆/哈佛大学以及国内和国际机构广受欢迎的合作者和导师。 指导计划/环境：此应用程序将利用以下网址提供的大量培训资源 布里格姆/哈佛大学，包括临床调查中心，布里格姆临床和医学研究所 翻译研究，以及各种专业的T32培训补助金。它还将利用无与伦比的 波士顿胡椒中心和其他资助研究的资源，作为POR实习生的平台 多个级别。 研究计划：这项K24奖支持的新颖研究将对 1a) ADT诱导的严重性腺功能减退和由此导致的肌肉质量下降对身体功能的影响 1b)ADT对骨骼肌脂肪渗透的影响及其与肌肉这种恶化的联系 身体功能的质量，以及2)睾酮替代改善癌症的机制- 患有癌症的老年男性的相关疲劳。 从三个主要方面了解雄激素缺乏对老年男性癌症的影响： 这些新的目标将建立在巴萨里亚博士正在进行的工作的基础上 当前的R01，探索新的假设，并为学员扩大机会。

PROJECT SUMMARY Shehzad Basaria, MD, an Associate Professor of Medicine and Endocrinology in the Division of Endocrinology, Diabetes, & Metabolism at Brigham and Women's Hospital, Harvard Medical School, submits this application for a K24 Mid-Career Development award to provide protected time to mentor trainees in Patient-Oriented Research (POR) in Endocrine aspects of Gero-Oncology. Dr. Basaria is one of the few endocrinologists worldwide specializing in endocrine and cardio-metabolic disorders in older men with cancer and androgen deficiency. He will pursue additional training to hone his mentoring skills in order to build on his established record of mentorship and foster the research careers of early investigators. Candidate: Dr. Basaria is a highly productive clinical researcher in the field of Endocrinology, Aging and Cancer. Since 2003, he has been continuously NIH-funded to investigate: i) endocrine and cardio-metabolic complications of androgen deprivation therapy (ADT) in men with prostate cancer (PCa), ii) benefits and risks of androgen replacement in older men, and iii) endocrinology of aging. He has conducted his investigations using NIH-supported infrastructure, including RO1s and R21 grants, data from the Baltimore Longitudinal Study of Aging (BLSA), the InChianti Study, and the Boston Pepper Center for Function-Promoting Therapies. With his uncommon skill set and strong POR program in Endocrinology and Gero-Oncology, he has been a sought-after collaborator and mentor at Brigham/Harvard and at national and international institutions. Mentoring Plan/Environment: This application will leverage the extensive training resources at Brigham/Harvard, including the Center for Clinical Investigation, the Brigham Research Institute for Clinical and Translational Research, and T32 training grants in a variety of specialties. It will also draw on the unparalleled resources of the Boston Pepper Center and other funded studies to serve as a platform for POR trainees at multiple levels. Research Plan: The novel research supported by this K24 award will make significant contributions to the 1A) The impact of ADT-induced profound hypogonadism and the resulting decline in muscle mass on physical function, 1B) The impact of ADT on fat infiltration of skeletal muscles and the association of this deterioration in muscle quality on physical function, and 2) The mechanisms by which testosterone replacement improves Cancer- Related Fatigue in older men with cancer. understanding of the impact of androgen deficiency in older men with cancer in three major areas: These novel aims will build on the ongoing work in Dr. Basaria's current R01s, explore new hypotheses, and expand opportunities for trainees.