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CF 2: Biostatistics and Bioinformatics Core

CF 2：生物统计学和生物信息学核心

基本信息

批准号：
10468960
负责人：
Li-Xuan Qin
金额：
$ 15.52万
依托单位：
SLOAN-KETTERING INST CAN RESEARCH
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-01 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10468960
关键词：
Address Advisory Committees Advocacy Attention Bioinformatics Biological Assay Biological Specimen Banks Biometry Biostatistics Core Cancer Center Cell Line Center Core Grants Characteristics Clinical Clinical Research Clinical Trials Clinical Trials Design Collaborations Consult Data Data Adjustments Data Analyses Data Set Databases Doctor of Philosophy Ensure Experimental Designs Formulation Goals Human Laboratory Research Manuscripts Memorial Sloan-Kettering Cancer Center Methodology Methods Molecular Analysis Molecular Profiling Pharmaceutical Preparations Phase Population Principal Investigator Procedures Protocols documentation Randomized Reporting Research Research Design Research Personnel Research Project Grants Sample Size Sampling Soft tissue sarcoma Statistical Data Interpretation Update Validation Writing base comparison group data exploration design laboratory experiment member molecular marker molecular scale novel predictive marker primary endpoint primary outcome protocol development research study response sarcoma secondary endpoint survival outcome translational cancer research tumor

项目摘要

Core 2: Biostatistics and Bioinformatics ABSTRACT The Biostatistics & Bioinformatics Core will support investigators of the Soft Tissue Sarcoma SPORE in the computational and statistical aspects of their research efforts, including the design and analysis of laboratory experiments, molecular profiling assays, and clinical trials. In laboratory experiments, core members will assist in the formulation of the experimental design and in the analysis and interpretation of the data at the conclusion of the study. The core will also assist in the large-scale molecular characterization of cell line and human tumor samples to identify predictors of tumor characteristics, drug response, and survival. In the clinical trial design phase, a core member will conduct a protocol review with the principal investigator; based on this review, a statistical section for the protocol will be provided, outlining major scientific objectives, population to be studied, primary and secondary endpoints, experimental design, analysis plans, and a targeted sample size justified in probabilistic terms; at the conclusion of the trial, data analyses will be performed to assess outcomes of the primary and secondary endpoints stated in the protocol. The core will perform statistical and bioinformatic analyses using appropriate state-of-the-art methodologies, and will develop alternative methods if current methodology does not adequately address a research question. In addition, the core will facilitate the management and updating of the clinical sarcoma database in collaboration with the leaders of research projects and the other three cores of the Soft Tissue Sarcoma SPORE.

核心2：生物统计学和生物信息学