DataBase Shared Resource

数据库共享资源：项目摘要 数据库共享资源（DBSR）的功能是开发、集成和维护一个集中的、 一个具有成本效益和良好特征的研究数据库，包括所有的赫伯特欧文综合 癌症中心（Cancer Center，CSCCC）肿瘤登记处。导演珍妮根金格，博士和凯瑟琳船员，医学博士，MS， 在过去的5年中，DBSR开发了一个标准化的协议，得到了个人的普遍同意 癌症患者或有癌症风险的人，以促进癌症研究中心内的新型和创新癌症研究，以及 更大的哥伦比亚大学欧文医学中心（CUIMC）社区。DBSR提供监督， 用于开发和维护多个癌症相关研究数据库的基础设施 癌症亚专科包括：（1）将所有先前的成人实体瘤登记整合到一个标准化的 方案;（2）通过电子健康数据的链接，开发一个回顾性患者队列 跨多个平台和数据仓库的电子病历（EHR）（即，纽约长老会医院 肿瘤登记）与现有的残留组织样本;和（3）开发和维护前瞻性 通过同意，收集生物样本（例如，血液、唾液）和流行病学数据 (e.g.,生活方式因素），并链接到来自EHR/NYPH肿瘤登记处的数据和残留组织样本。 DBSR还协调研究数据库相关服务与其他共享资源。此外，DBSR 通过以下方式为研究界提供支持：（1）将招募纳入癌症的辅助研究 （2）通过招聘人员审查访问癌症相关研究数据库的请求， 专门的科学审查委员会和跟踪请求的利用情况（即，出版的手稿，资金 （3）向研究人员传播有关癌症相关研究数据库的信息， 以促进癌症研究创新。在本项目期间（2014-2019年）， DBSR将24个临床登记中心整合到一个总体研究数据库中。由于高素质和 双语招聘人员，DBSR已达到其应计目标，并招收了4,700多人，从他们DBSR已 收集了2,400多个生物标本和2,600多份问卷。为了促进高度创新的研究， DBSR已批准并完成了120多个数据和生物样本请求，并支持了10多个辅助 通过有效的登记和数据提取进行研究。通过这一点，DBSR已经支持了几个联邦政府 资助的赠款。在本项目期间，35个国家和地区协调委员会利用了DBSR的功能 成员和支持的关键数据和见解的31个成员同行评审的出版物，其中包括五个 影响因子>10的论文和参考癌症期刊中的手稿（例如，癌症流行病学， 生物标志物和预防，临床癌症研究，癌症预防研究）。DBSR支持 研究在三个国家癌症研究所资助的研究项目赠款。

DATABASE SHARED RESOURCE: PROJECT SUMMARY The function of the DataBase Shared Resource (DBSR) is to develop, integrate, and maintain a centralized, cost-effective, and well-characterized research database encompassing all the Herbert Irving Comprehensive Cancer Center (HICCC) tumor registries. Directed by Jeanine Genkinger, PhD and Katherine Crew, MD, MS, the DBSR has, over the past five years, developed a standardized protocol with universal consent of individuals with cancer or at risk for cancer to promote novel and innovative cancer research within the HICCC, as well as the larger Columbia University Irving Medical Center (CUIMC) community. The DBSR provides oversight and infrastructure for the development and maintenance of a cancer-related research database across multiple cancer subspecialties including: (1) integration of all prior adult solid tumor registries into one standardized protocol; (2) development of a retrospective cohort of patients through linkage of data from electronic health records (EHRs) across multiple platforms and data warehouses (i.e., New York-Presbyterian Hospital [NYPH] Tumor Registry) with existing residual tissue samples; and (3) development and maintenance of a prospective cohort implemented through consenting, collecting biospecimens (e.g., blood, saliva) and epidemiologic data (e.g., lifestyle factors), and linking to data from the EHR/NYPH Tumor Registry and residual tissue samples. DBSR also coordinates research database-related services with other Shared Resources. In addition, DBSR provides support to the research community by: (1) incorporating recruitment to ancillary studies in the cancer clinics via recruitment staff, (2) reviewing requests to access the cancer-related research database via a dedicated Scientific Review Committee and tracking utilization of requests (i.e., manuscripts published, funding awarded), and (3) disseminating information about the cancer-related research database to the research and lay community to promote novel and innovative cancer research. Over the current project period (2014-2019), DBSR integrated 24 clinical registries into one overarching research database. Due to highly qualified and bilingual recruiters, DBSR has met its accrual targets and enrolled over 4,700 individuals, from whom DBSR has collected over 2,400 biospecimens, and over 2,600 questionnaires. To foster highly innovative research, the DBSR has approved and fulfilled over 120 data and biospecimen requests and supported over 10 ancillary studies through efficient enrollment and data extraction. Through this, the DBSR has supported several federally funded grants. Over the current project period, the capabilities of the DBSR have been utilized by 35 HICCC members and supported key data and insights for 31 HICCC member peer-reviewed publications, including five papers with impact factor >10 and manuscripts in reference cancer journals (e.g., Cancer Epidemiology, Biomarkers & Prevention, Clinical Cancer Research, Cancer Prevention Research). Currently DBSR support research in three NCI-funded research project grants.