Molecular Oncology Training Program

项目概要 这是一项为哥伦比亚大学最近设立的博士后培训项目提供资金的提案 对医生进行研究技术培训，这些技术将构成转化研究职业的基础 癌症生物学、诊断和治疗。我们将识别并招募具有杰出研究的人才 已完成肿瘤内科临床培训并为他们的富有成效的职业做好准备的潜力 肿瘤学的转化研究者。我们将利用一个为期两年的综合计划，包括教学、 研讨会、小组会议、课程作业（包括可能的硕士学位）和个性化培训 在哥伦比亚大学教师的研究项目中，以发展参与者的职业生涯。资金 要求以分级方式每年支持最多 6 名学员。 分子肿瘤学培训计划的教员由 46 名独立研究人员组成，他们将提供 对学员的直接监督。教职员工均由 NCI 和该学院其他分支机构统一资助 美国国立卫生研究院 (NIH) 和其他以癌症为重点的研究组织，并已成为该领域的思想领袖。 广泛的癌症相关学科。教职员工被分为不同的主要主题领域 培训项目：I) 精准肿瘤学和系统生物学，II) 癌症基因组学和表观基因组学和 III) 肿瘤生物学和微环境。参与的教师是根据他们的研究确定的 生产力和质量，与其他研究人员的合作，通常是跨研究学科的， 以及支持和发展超越博士后水平的研究职业的历史。的 受训者将从一组经过精心挑选的忠诚的医师研究人员中竞争性地选出 过去的成就以及他们作为富有成效的、独立的翻译职业发展职业的潜力 调查人员。 分子肿瘤学培训计划将得到哥伦比亚大学多样化研究资源的支持 大学以及对肿瘤学的持续扩展和承诺，包括实验室和 临床重点研究。欧文癌症研究中心的开业预示着这一扩张 哥伦比亚大学欧文医学中心内一座 300,000 平方英尺的建筑，完全致力于 癌症研究以及正在为该部门招募领先的临床转化研究人员 血液学和肿瘤内科。这些变化极大地拓宽了研究的多样性 哥伦比亚大学的质量也随之提高，使哥伦比亚大学跻身顶尖大学行列 肿瘤学项目，并吸引了一批训练有素、致力于以下领域职业的医生 转化癌症生物学。

PROJECT SUMMARY This is a proposal to re-fund a recently established post-doctoral training program at Columbia University focused on training physicians in research techniques that will form the basis of careers in translational investigation of cancer biology, diagnosis and treatment. We will identify and recruit individuals with outstanding research potential who have completed clinical training in medical oncology and prepare them for productive careers as translational investigators in oncology. We will utilize a comprehensive two-year program comprised of didactics, workshops, small group sessions, coursework, including a possible master's degree, and individualized training within the research programs of Columbia University faculty to develop the careers of the participants. Funds are requested in a graded fashion to support up to 6 trainees annually. The Molecular Oncology Training Program faculty is comprised of 46 independent investigators who will provide direct supervision of the trainees. The faculty members are uniformly funded by the NCI, other branches of the NIH and other cancer-focused research organizations and have established themselves as thought-leaders in a broad range of cancer-related disciplines. Faculty members are divided into the main thematic areas of the training program: I) Precision Oncology and Systems Biology, II) Cancer Genomics and Epigenomics and III) Tumor Biology and Microenvironment. Participating faculty have been identified on the basis of their research productivity and quality, demonstrated collaboration with other investigators, often across research disciplines, and a history of supporting and developing research careers that transition beyond the post-doctoral level. The trainees will be chosen competitively from a highly select group of committed physician researchers on the basis of past accomplishments and their potential to develop careers as productive, independent translational investigators. The Molecular Oncology Training Program will be supported by the diverse research resources at Columbia University and the ongoing expansion and commitment to oncology that has included both laboratory and clinically focused research. The expansion was heralded by the opening of the Irving Cancer Research Center a 300,000 square-foot building within the Columbia University Irving Medical Center that is entirely dedicated to cancer research and the ongoing recruitment of leading clinical-translational research faculty to the Division of Hematology and Medical Oncology. These changes have significantly broadened the diversity of research at Columbia University with a concomitant increase in quality that has established Columbia in the top tier of oncology programs and has attracted a pool of consummately trained physicians committed to careers in translational cancer biology.