Molecular Oncology Training Program

项目总结 这是一项重新资助哥伦比亚大学最近建立的博士后培训项目的提案，该项目侧重于 关于培训医生的研究技术，这将成为翻译调查职业生涯的基础 癌症生物学、诊断和治疗。我们将物色和招募具有杰出研究成果的人员。 已完成内科肿瘤学临床培训并为从事富有成效的职业生涯做好准备的潜在人员 肿瘤学中的转译调查人员。我们将利用一个为期两年的全面计划，包括教学论， 讲习班、小组会议、课程作业，包括可能的硕士学位，以及个性化培训 在哥伦比亚大学教职员工的研究计划内发展参与者的职业生涯。基金 要求以分级方式每年支持最多6名受训人员。 分子肿瘤学培训计划教职员工由46名独立调查人员组成，他们将提供 直接监督实习生。教职员工由NCI、NCI的其他分支机构统一资助 NIH和其他专注于癌症的研究组织，并在 广泛的癌症相关学科。教员们被分成了 培训方案：一)精确肿瘤学和系统生物学，二)癌症基因组学和表观基因组学，三) 肿瘤生物学与微环境。参与的教员是根据他们的研究确定的 生产率和质量，表现出与其他研究人员的合作，通常是跨研究学科， 以及支持和发展超越博士后水平的研究事业的历史。这个 受训人员将从高度精选的致力于内科研究人员的小组中竞争性地挑选出来 过去的成就及其作为富有成效的、独立翻译的职业发展的潜力 调查人员。 分子肿瘤学培训计划将得到哥伦比亚大学多样化研究资源的支持 大学以及对肿瘤学的持续扩展和承诺，包括实验室和 专注于临床的研究。欧文癌症研究中心的开业预示着这一扩张 哥伦比亚大学欧文医疗中心内30万平方英尺的建筑，完全致力于 癌症研究和正在招聘的领先临床-翻译研究教员到 血液学和内科肿瘤学。这些变化极大地扩大了研究的多样性 哥伦比亚大学，伴随着质量的提高，使哥伦比亚大学跻身 肿瘤学课程，并吸引了一批训练有素的医生致力于 翻译癌症生物学。

PROJECT SUMMARY This is a proposal to re-fund a recently established post-doctoral training program at Columbia University focused on training physicians in research techniques that will form the basis of careers in translational investigation of cancer biology, diagnosis and treatment. We will identify and recruit individuals with outstanding research potential who have completed clinical training in medical oncology and prepare them for productive careers as translational investigators in oncology. We will utilize a comprehensive two-year program comprised of didactics, workshops, small group sessions, coursework, including a possible master's degree, and individualized training within the research programs of Columbia University faculty to develop the careers of the participants. Funds are requested in a graded fashion to support up to 6 trainees annually. The Molecular Oncology Training Program faculty is comprised of 46 independent investigators who will provide direct supervision of the trainees. The faculty members are uniformly funded by the NCI, other branches of the NIH and other cancer-focused research organizations and have established themselves as thought-leaders in a broad range of cancer-related disciplines. Faculty members are divided into the main thematic areas of the training program: I) Precision Oncology and Systems Biology, II) Cancer Genomics and Epigenomics and III) Tumor Biology and Microenvironment. Participating faculty have been identified on the basis of their research productivity and quality, demonstrated collaboration with other investigators, often across research disciplines, and a history of supporting and developing research careers that transition beyond the post-doctoral level. The trainees will be chosen competitively from a highly select group of committed physician researchers on the basis of past accomplishments and their potential to develop careers as productive, independent translational investigators. The Molecular Oncology Training Program will be supported by the diverse research resources at Columbia University and the ongoing expansion and commitment to oncology that has included both laboratory and clinically focused research. The expansion was heralded by the opening of the Irving Cancer Research Center a 300,000 square-foot building within the Columbia University Irving Medical Center that is entirely dedicated to cancer research and the ongoing recruitment of leading clinical-translational research faculty to the Division of Hematology and Medical Oncology. These changes have significantly broadened the diversity of research at Columbia University with a concomitant increase in quality that has established Columbia in the top tier of oncology programs and has attracted a pool of consummately trained physicians committed to careers in translational cancer biology.