DataBase Shared Resource

数据库共享资源：项目摘要 数据库共享资源(DBSR)的功能是开发、集成和维护一个集中的、 性价比高，特点良好的研究数据库，包括所有赫伯特·欧文综合 癌症中心(HICCC)肿瘤登记。导演珍宁·根金格，博士和凯瑟琳·克鲁斯，医学博士，硕士， 在过去的五年里，DBSR制定了一项标准化的议定书，得到了个人的普遍同意 在HICCC内促进新的和创新的癌症研究，以及 更大的哥伦比亚大学欧文医学中心(CUIMC)社区。DBSR提供监督和 基础设施，用于开发和维护跨多个领域的癌症研究数据库 癌症专科包括：(1)将所有以前的成人实体肿瘤登记整合为一个标准化的登记 方案；(2)通过将电子健康数据联系起来，建立一个有追溯力的患者队列 跨多个平台和数据仓库的记录(EHR)(例如，纽约长老会医院[NYPH] 肿瘤登记处)；以及(3)开发和维护预期的 通过同意、收集生物样本(例如血液、唾液)和流行病学数据实施队列 (例如，生活方式因素)，并链接到EHR/NYPH肿瘤登记处的数据和残留组织样本。 DBSR还与其他共享资源协调与研究数据库相关的服务。此外，DBSR 通过以下方式为研究界提供支持：(1)将招募纳入癌症辅助研究 通过招聘工作人员访问诊所；(2)审查通过 专门的科学审查委员会和跟踪请求的利用情况(例如，出版的手稿、资金 获奖)，以及(3)将与癌症相关的研究数据库的信息传播给研究和 促进新的和创新的癌症研究的非专业社区。在本项目期间(2014-2019年)， DBSR将24个临床注册中心整合到一个重要的研究数据库中。由于高资质和 双语招聘人员，DBSR已经实现了其应计目标，并招募了超过4700名个人，DBSR从他们那里获得了 收集了2400多份生物标本和2600多份问卷。为了促进高度创新的研究， DBSR已批准和履行了120多项数据和生物样品请求，并支持了10多项辅助 通过有效的招生和数据提取进行研究。通过这一点，DBSR已经支持了几个联邦政府 资助的赠款。在当前项目期内，35个HICCC利用了DBSR的能力 为31份经HICCC成员同行审查的出版物提供关键数据和见解，其中包括5份 具有影响因子的论文和参考癌症期刊(例如，癌症流行病学， 生物标记物与预防、临床癌症研究、癌症预防研究)。目前支持DBSR NCI资助的三个研究项目拨款中的研究。

DATABASE SHARED RESOURCE: PROJECT SUMMARY The function of the DataBase Shared Resource (DBSR) is to develop, integrate, and maintain a centralized, cost-effective, and well-characterized research database encompassing all the Herbert Irving Comprehensive Cancer Center (HICCC) tumor registries. Directed by Jeanine Genkinger, PhD and Katherine Crew, MD, MS, the DBSR has, over the past five years, developed a standardized protocol with universal consent of individuals with cancer or at risk for cancer to promote novel and innovative cancer research within the HICCC, as well as the larger Columbia University Irving Medical Center (CUIMC) community. The DBSR provides oversight and infrastructure for the development and maintenance of a cancer-related research database across multiple cancer subspecialties including: (1) integration of all prior adult solid tumor registries into one standardized protocol; (2) development of a retrospective cohort of patients through linkage of data from electronic health records (EHRs) across multiple platforms and data warehouses (i.e., New York-Presbyterian Hospital [NYPH] Tumor Registry) with existing residual tissue samples; and (3) development and maintenance of a prospective cohort implemented through consenting, collecting biospecimens (e.g., blood, saliva) and epidemiologic data (e.g., lifestyle factors), and linking to data from the EHR/NYPH Tumor Registry and residual tissue samples. DBSR also coordinates research database-related services with other Shared Resources. In addition, DBSR provides support to the research community by: (1) incorporating recruitment to ancillary studies in the cancer clinics via recruitment staff, (2) reviewing requests to access the cancer-related research database via a dedicated Scientific Review Committee and tracking utilization of requests (i.e., manuscripts published, funding awarded), and (3) disseminating information about the cancer-related research database to the research and lay community to promote novel and innovative cancer research. Over the current project period (2014-2019), DBSR integrated 24 clinical registries into one overarching research database. Due to highly qualified and bilingual recruiters, DBSR has met its accrual targets and enrolled over 4,700 individuals, from whom DBSR has collected over 2,400 biospecimens, and over 2,600 questionnaires. To foster highly innovative research, the DBSR has approved and fulfilled over 120 data and biospecimen requests and supported over 10 ancillary studies through efficient enrollment and data extraction. Through this, the DBSR has supported several federally funded grants. Over the current project period, the capabilities of the DBSR have been utilized by 35 HICCC members and supported key data and insights for 31 HICCC member peer-reviewed publications, including five papers with impact factor >10 and manuscripts in reference cancer journals (e.g., Cancer Epidemiology, Biomarkers & Prevention, Clinical Cancer Research, Cancer Prevention Research). Currently DBSR support research in three NCI-funded research project grants.