FASD Diagnostic Telemedicine Resource

FASD 诊断远程医疗资源

• 批准号: 10470671
• 负责人: Miguel del Campo Casanelles
• 金额: $ 37.04万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-15 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10470671
• 关键词: 3-Dimensional; Address; Adult; Alaska; Alcohols; Algorithms; Area; Brain; Cellular Phone; Characteristics; Child; Clinic; Clinical; Collaborations; Communities; Complement; Computers; Detection; Development; Diagnosis; Diagnostic; Diagnostic Imaging; Diagnostic Services; Dysmorphology; Early Intervention; Ensure; Evaluation; Face; Failure; Fetal Alcohol Exposure; Fetal Alcohol Spectrum Disorder; Funding; Genes; Goals; Gold; Health Personnel; Healthcare; Image; Improve Access; Individual; Intervention; Life; Live Birth; Measurement; Methods; Modality; Monitor; Patient Recruitments; Persons; Physical assessment; Provider; Public Health; Research; Research Personnel; Resources; Sampling; Services; Site; Standardization; Syndrome; Telemedicine; Testing; Training; Trees; Work; accurate diagnosis; base; cost; diagnostic accuracy; disease classification; eHealth; effectiveness evaluation; feature detection; fetal diagnosis; geographic barrier; health training; improved; novel; prenatal; screening; tool

Project Summary Prenatal alcohol exposure is estimated to impact 1-5% of children in the US alone. Yet, many individuals who have been exposed prenatally to alcohol and suffer from fetal alcohol spectrum disorders (FASD) fail to be recognized. This failure is due, in large part, to a paucity of specialized clinics and expert dysmorphologists who are trained to identify FASD. Access to appropriate diagnostic expertise is particularly limited in remote areas. Unfortunately, if individuals with FASD are not recognized and diagnosed, they do not receive critically needed services nor can they access potential interventions early in life, when intervention is most likely to be effective. The CIFASD5 Diagnostic-Telemedicine Resource (DTR) will ensure consistent and accurate assessment of the physical characteristics of FASD across the CIFASD research sites. In addition, the DTR will address the critical need for increased diagnostic capacity through training of non-expert practitioners across CIFASD5 sites using telemedicine-based methods. In the previous CIFASD4 iteration, telemedicine approaches were tested for this purpose in a small sample of clinicians and found to be an effective method for training and monitoring of new examiners. In CIFASD5, this method will be extended to multiple sites and be employed in the evaluation of over 1,800 children and adults. However, telemedicine alone is insufficient to expand capacity and ensure consistency and accuracy of diagnosis. To that end, several novel eHealth tools have been developed to assist in the detection of physical features associated with prenatal alcohol exposure. These tools hold promise in providing simple and efficient ways to screen and identify FASD. These include MorpheusQ, a smart-phone based app that automates facial feature detection; Face-to-Gene, a 2D facial image diagnostic aid used by clinical geneticists to screen for potential syndromes; and 3D facial image signatures. These tools are scalable and have the potential to improve screening and diagnosis across the globe, even in remote areas, such as in Alaska. However, the diagnostic accuracy of these tools needs to be systematically compared to standardized dysmorphological exams. It is essential to determine whether eHealth tools can effectively replace and/or improve traditional exams before they are widely implemented.

项目摘要 据估计，仅在美国，就估计有1-5％的儿童暴露于产前酒精。但是，很多 在产前暴露于酒精并患有胎儿酒精谱的人 疾病（FASD）无法被识别。这种失败在很大程度上是由于缺乏专业的 接受培训可以识别FASD的诊所和专家畸形学家。访问适当 诊断专业知识在偏远地区特别有限。不幸的是，如果患有FASD的人 没有认可和诊断，他们没有获得急需的服务，也不会 当干预措施最有效时，在生命的早期就可以访问潜在的干预措施。 CIFASD5诊断 - 甲状腺氨酸资源（DTR）将确保一致，准确 评估CIFASD研究地点FASD的物理特征。在 此外，DTR将通过培训来满足提高诊断能力的关键需求 使用基于远程医疗的方法，跨CIFASD5站点的非专家实践者的of。在 以前的CIFASD4迭代，为此目的对远程医疗方法进行了测试 临床医生样本，发现是培训和监测新的有效方法 考官。在CIFASD5中，此方法将扩展到多个站点，并在 评估1,800多名儿童和成人。 但是，仅远程医疗不足以扩大能力并确保一致性和 诊断的准确性。为此，已经开发了几种新型的eHealth工具来协助 检测与产前酒精相关的物理特征。这些工具可以满足 承诺提供简单有效的方法来筛选和识别FASD。这些包括 Morpheusq，一个基于智能手机的应用程序，可自动化面部功能检测；面对面，a 临床遗传学家用来筛查潜在综合征的2D面部图像诊断辅助。和 3D面部图像签名。这些工具是可扩展的，有可能改善筛选 以及全球诊断，甚至在偏远地区，例如阿拉斯加。但是，诊断 这些工具的准确性需要系统地与标准化的畸形学比较 考试。确定eHealth工具是否可以有效替代和/或改进是至关重要的 传统考试在广泛实施之前。