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FASD Diagnostic Telemedicine Resource

FASD 诊断远程医疗资源

基本信息

批准号：
10703404
负责人：
Miguel del Campo Casanelles
金额：
$ 35.51万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-15 至 2027-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10703404
关键词：
3-Dimensional Address Adult Alaska Alcohols Algorithms Area Brain Characteristics Child Clinic Clinical Collaborations Communities Complement Computers Detection Development Diagnosis Diagnostic Diagnostic Imaging Diagnostic Services Dysmorphology Early Intervention Ensure Evaluation Face Failure Fetal Alcohol Exposure Fetal Alcohol Spectrum Disorder Funding Genes Goals Health Personnel Healthcare Image Improve Access Individual Intervention Life Live Birth Measurement Methods Modality Monitor Patient Recruitments Persons Physical assessment Probability Provider Public Health Research Research Personnel Resources Sampling Services Site Standardization Syndrome Telemedicine Testing Training Trees Work accurate diagnosis cost diagnostic accuracy disease classification eHealth effectiveness evaluation feature detection fetal diagnosis geographic barrier health training improved novel prenatal screening smartphone application tool

项目摘要

Project Summary Prenatal alcohol exposure is estimated to impact 1-5% of children in the US alone. Yet, many individuals who have been exposed prenatally to alcohol and suffer from fetal alcohol spectrum disorders (FASD) fail to be recognized. This failure is due, in large part, to a paucity of specialized clinics and expert dysmorphologists who are trained to identify FASD. Access to appropriate diagnostic expertise is particularly limited in remote areas. Unfortunately, if individuals with FASD are not recognized and diagnosed, they do not receive critically needed services nor can they access potential interventions early in life, when intervention is most likely to be effective. The CIFASD5 Diagnostic-Telemedicine Resource (DTR) will ensure consistent and accurate assessment of the physical characteristics of FASD across the CIFASD research sites. In addition, the DTR will address the critical need for increased diagnostic capacity through training of non-expert practitioners across CIFASD5 sites using telemedicine-based methods. In the previous CIFASD4 iteration, telemedicine approaches were tested for this purpose in a small sample of clinicians and found to be an effective method for training and monitoring of new examiners. In CIFASD5, this method will be extended to multiple sites and be employed in the evaluation of over 1,800 children and adults. However, telemedicine alone is insufficient to expand capacity and ensure consistency and accuracy of diagnosis. To that end, several novel eHealth tools have been developed to assist in the detection of physical features associated with prenatal alcohol exposure. These tools hold promise in providing simple and efficient ways to screen and identify FASD. These include MorpheusQ, a smart-phone based app that automates facial feature detection; Face-to-Gene, a 2D facial image diagnostic aid used by clinical geneticists to screen for potential syndromes; and 3D facial image signatures. These tools are scalable and have the potential to improve screening and diagnosis across the globe, even in remote areas, such as in Alaska. However, the diagnostic accuracy of these tools needs to be systematically compared to standardized dysmorphological exams. It is essential to determine whether eHealth tools can effectively replace and/or improve traditional exams before they are widely implemented.

项目摘要据估计，仅在美国，产前接触酒精就会影响1-5%的儿童。但很多产前暴露于酒精并患有胎儿酒精谱的个体疾病（FASD）不能被识别。这一失败在很大程度上是由于缺乏专门的接受过FASD识别培训的畸形学家。获得适当在偏远地区，诊断专门知识尤其有限。不幸的是，如果患有FASD的人得不到承认和诊断，他们得不到急需的服务，在生命早期获得潜在的干预措施，此时干预措施最有可能有效。 CIFASD 5诊断-远程医疗资源（DTR）将确保一致和准确在CIFASD研究中心评估FASD的物理特征。在此外，DTR将通过培训来满足提高诊断能力的迫切需要 CIFASD 5网站使用基于远程医疗的方法的非专家从业人员。在在先前的CIFASD 4迭代中，远程医疗方法在一个小的样本的临床医生，并发现是一种有效的方法，培训和监测新的考官在CIFASD 5中，该方法将扩展到多个站点，并在对1,800多名儿童和成人进行了评估。然而，光靠远程医疗不足以扩大能力和确保一致性，诊断的准确性。为此，开发了一些新的电子保健工具，以协助检测与产前酒精暴露相关的身体特征。这些工具可以承诺提供简单有效的方法来筛选和识别FASD。这些包括 MorpheusQ，一个基于智能手机的应用程序，自动化面部特征检测; Face-to-Gene，一个 2D面部图像诊断辅助临床遗传学家用于筛选潜在的综合征;和 3D面部图像签名。这些工具是可扩展的，有潜力改善筛查和诊断在地球仪，甚至在偏远地区，如在阿拉斯加。然而，诊断这些工具的准确性需要系统地与标准化的形态学考试必须确定电子卫生工具是否能够有效地取代和/或改善传统的考试在广泛实施之前。

项目成果

期刊论文数量（14）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Altered Parietal Activation during Non-symbolic Number Comparison in Children with Prenatal Alcohol Exposure.

产前酒精暴露儿童在非符号数字比较过程中顶叶激活发生变化

DOI：
10.3389/fnhum.2017.00627
发表时间：
2017
期刊：
Frontiers in human neuroscience
影响因子：
2.9
作者：
Woods KJ;Jacobson SW;Molteno CD;Jacobson JL;Meintjes EM
通讯作者：
Meintjes EM

An auditory Go/No-Go study of event-related potentials in children with fetal alcohol spectrum disorders.

胎儿酒精谱系障碍儿童事件相关电位的听觉 Go/No-Go 研究。

DOI：
10.1109/iembs.2011.6090181
发表时间：
2011
期刊：
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
影响因子：
0
作者：
Steinmann,TobiasP;Andrew,ColinM;Thomsen,CarstenE;Kjær,TroelsW;Meintjes,ErnestaM;Molteno,ChristopherD;Jacobson,JosephB;Jacobson,SandraW;Sorensen,HelgeBD
通讯作者：
Sorensen,HelgeBD

Developmental pathogenesis of short palpebral fissure length in children with fetal alcohol syndrome.

胎儿酒精综合征儿童睑裂长度短的发育发病机制。

DOI：
10.1002/bdra.20585
发表时间：
2009
期刊：
Birth defects research. Part A, Clinical and molecular teratology
影响因子：
0
作者：
Jones,KennethLyons;Hoyme,HEugene;Robinson,LutherK;delCampo,Miguel;Manning,MelanieA;Bakhireva,LudmilaN;Prewitt,LelaM;Chambers,ChristinaD
通讯作者：
Chambers,ChristinaD

Parietal dysfunction during number processing in children with fetal alcohol spectrum disorders.

患有胎儿酒精谱系障碍的儿童在数字处理过程中的顶叶功能障碍。