The Neural Effects of Balance Versus Aerobic Training in Individuals with Degenerative Cerebellar Diseases

平衡与有氧训练对退行性小脑疾病患者的神经影响

• 批准号: 10470352
• 负责人: Scott Barbuto
• 金额: $ 19.35万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10470352
• 关键词: Aerobic; Aerobic Exercise; Affect; Animals; Area; Ataxia; Back; Balance training; Brain; Brain scan; Cerebellar Diseases; Cerebellar degeneration; Cerebellum; Cessation of life; Clinical; Clinical Research; Data; Dendrites; Diagnosis; Diffusion Magnetic Resonance Imaging; Disease; Disease Progression; Doctor of Philosophy; Equilibrium; Exercise; Financial compensation; Future; Goals; Home; Immunology; Individual; Inherited; K-Series Research Career Programs; Learning; Locomotion; MRI Scans; Master' s Degree; Measures; Mentors; Methods; Motor Skills; Movement Disorders; Neurologic; Neurologic Signs; Neuronal Plasticity; Participant; Persons; Pharmaceutical Preparations; Physical Medicine; Physical Rehabilitation; Population; Public Health; Randomized; Regimen; Research; Research Design; Research Personnel; Research Project Grants; Research Support; Rest; Spinocerebellar Ataxias; Spinocerebellar Degenerations; Statistical Data Interpretation; Statistical Methods; Structure; Synapses; Techniques; Testing; Training; Training Programs; United States National Institutes of Health; Wheelchairs; Work; career; career development; clinically significant; disability; effective therapy; exercise training; functional MRI scan; gray matter; improved; interest; multidisciplinary; neuroimaging; programs; relating to nervous system; responsible research conduct; sedentary; skills; symptomatic improvement

PROJECT SUMMARY/ABSTRACT Degenerative cerebellar diseases are a group of disorders that cause severe disability and can be fatal. There are currently no known disease-modifying treatments available for use, and there is a critical need to find treatments that slow disease progression and allow affected individuals to live more functional lives. Balance and aerobic training show promise as treatments for degenerative cerebellar diseases, but the neural effects of both training methods have not been thoroughly investigated. It is crucial to understand how the training impacts the brain, and particularly the cerebellum, in order to determine if one training method is better at slowing disease progression than the other. The goal of this proposal is to compare the neural effects of balance versus aerobic training in individuals with degenerative cerebellar diseases. We hypothesize that aerobic training causes neuroplastic changes within the cerebellum whereas balance training causes improvements for people with cerebellar degeneration by impacting brain structures outside the cerebellum. If our hypothesis is true, aerobic training may have more influence on disease progression than balance training as it directly impacts the cerebellum. To investigate our hypothesis, various neuroimaging techniques will be used, which will allow the candidate to gain invaluable expertise in processing and analyzing brain scans. In AIM 1, we will compare cerebellar volume before and after the participants perform either 6-months of balance or aerobic training. In AIM 2, we will investigate whether neural changes have clinical significance by correlating cerebellar volume changes with clinical measures of ataxia. Finally, for AIM 3, we will use diffusion tensor imaging and resting state fMRI scans to examine how both training methods impact cerebellar microstructure and functional cerebellar connections. We hope that a detailed understanding of how each training method impacts the cerebellum will lead to more targeted training regimens with the goal of slowing disease progression of these devastating diseases. The candidate has a clinical background in Physical Medicine and Rehabilitation with an emphasis on movement disorders. He has a PhD in immunology and will be completing a master’s degree in clinical research design and statistical analysis. He is committed to a career in ataxia research focusing on the effects of exercise training on disease progression and plans to use the additional training he receives through this NIH Career Development Award to support his future work in this field. The candidate has assembled a multidisciplinary mentoring team to accomplish three training goals: 1) to learn and master neuroimaging techniques; 2) to become proficient in longitudinal statistical methods; 3) to improve grantsmanship skills to facilitate ongoing research support. In addition, the candidate will receive further training in career development and the responsible conduct of research.

项目概要/摘要 退行性小脑疾病是一组导致严重残疾并可能致命的疾病。那里 目前还没有已知的疾病缓解疗法可供使用，迫切需要找到 减缓疾病进展并使受影响的个体过上更正常的生活的治疗。平衡 有氧训练有望治疗退行性小脑疾病，但其神经效应 这两种训练方法尚未得到彻底研究。了解培训的方式至关重要 影响大脑，特别是小脑，以确定一种训练方法是否更适合 比其他药物更能减缓疾病进展。 该提案的目的是比较平衡训练与有氧训练对患有以下疾病的个体的神经影响： 退行性小脑疾病。我们假设有氧训练会导致神经可塑性变化 小脑，而平衡训练可以通过以下方式改善小脑退化患者的症状： 影响小脑以外的大脑结构。如果我们的假设成立，有氧训练可能会带来更多好处 对疾病进展的影响比平衡训练更重要，因为它直接影响小脑。 为了研究我们的假设，将使用各种神经影像技术，这将使候选人能够 获得处理和分析脑部扫描的宝贵专业知识。在 AIM 1 中，我们将比较小脑 参与者进行 6 个月的平衡或有氧训练之前和之后的体积。在 AIM 2 中，我们 将通过关联小脑体积变化来研究神经变化是否具有临床意义 与共济失调的临床措施。最后，对于 AIM 3，我们将使用扩散张量成像和静息态 fMRI 扫描以检查两种训练方法如何影响小脑微观结构和功能性小脑 连接。我们希望详细了解每种训练方法如何影响小脑 导致更有针对性的训练方案，以减缓这些破坏性疾病的进展 疾病。 候选人具有物理医学和康复方面的临床背景，重点是 运动障碍。他拥有免疫学博士学位，并将完成临床硕士学位 研究设计和统计分析。他致力于共济失调研究，专注于其影响 运动训练对疾病进展的影响，并计划利用他通过此训练获得的额外训练 NIH 职业发展奖以支持他未来在该领域的工作。候选人已经组建了一个 多学科指导团队完成三个培训目标：1）学习和掌握神经影像学 技术； 2）精通纵向统计方法； 3）提高资助技能 促进持续的研究支持。此外，候选人还将接受职业发展方面的进一步培训 以及负责任的研究行为。