Chronic outdoor air pollution, airway epithelial "omics" and asthma exacerbations in children
慢性室外空气污染、气道上皮“组学”和儿童哮喘恶化
基本信息
- 批准号:10470284
- 负责人:
- 金额:$ 16.03万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-08-15 至 2025-06-30
- 项目状态:未结题
- 来源:
- 关键词:AddressAirAir PollutionAncillary StudyAsthmaBehavior TherapyBehavioralBiological MarkersBiological Specimen BanksCaringCause of DeathChildChild CareChild health careChildhood AsthmaChronicClinicalClinical ManagementClinical TrialsCross-Sectional StudiesDNADNA MethylationDataDevelopmentDevelopment PlansDiseaseEmergency SituationEnvironmentEpidemiologyEpigenetic ProcessEvidence based interventionExposure toFundingGene ExpressionGenesGenomicsGoalsGovernmentHealth Care CostsHealth PersonnelHospitalizationIndividualInterventionK-Series Research Career ProgramsKnowledgeLeadLung diseasesMentorsMethodsMethylationModelingNasal EpitheliumNoseNutritionalOutcomeParticulate MatterPathogenesisPilot ProjectsPlayPoliciesPollutionPositioning AttributePredispositionPreparationProxyPuerto RicanRandomized Clinical TrialsRecommendationResearchRiskSamplingSchoolsStatistical Data InterpretationStatistical MethodsSusceptibility GeneTestingTherapeuticTimeTissue-Specific Gene ExpressionTissuesTrainingUnited States Environmental Protection AgencyUnited States National Institutes of HealthVisitVitamin DWorkairway epitheliumambient air pollutionasthma exacerbationcare providerscareer developmentclinical careclinical practicecohortdesigndifferential expressionepigenetic variationethnic diversityfine particlesgenome-widehealth care service utilizationimprovedindexinginsightmethylation biomarkernovelnovel therapeuticspollutantpredictive markerpredictive toolspreventresponseskill acquisitionskillstooltraffic-related air pollutiontranscriptomics
项目摘要
ABSTRACT:
Outdoor air pollution is a known cause of childhood asthma exacerbations yet is rarely addressed in routine
asthma care. This gap between scientific knowledge and clinical practice must be addressed to improve
healthcare for children with asthma. While there is no ‘safe’ level of pollution, personal susceptibility to both air
pollution and asthma exacerbations varies in children. Childhood asthma exacerbations are difficult to predict,
lead to missed school and parental work days, and contribute substantially to healthcare utilization and costs. It
is unclear if our current asthma therapies protect against pollution-induced exacerbations. Pollution reduction
policies are the best intervention, yet until such time as ‘clean’ air is guaranteed for all, developing biomarkers
identifying children at greatest risk of pollution-induced exacerbations are needed to develop interventions.
The airway epithelium is an ideal tissue to study omics and develop new biomarkers of pollution-induced
asthma exacerbations, as susceptibility genes for asthma are expressed in airway epithelium and pollutants
(e.g. particulate matter <2.5𝜇m (PM2.5)) induce epigenetic and gene expression changes. Little is known about
the effects of chronic pollution exposure on DNA methylation and gene expression in children with asthma, or
whether such changes are associated with asthma exacerbations. Further, it is unknown if pollution avoidance
recommendations (the Air Quality Index (AQI)) results in differential DNA methylation or gene expression. This
proposal will: 1) determine the association between exposure to PM2.5 and residential proximity to a major road
(a proxy for traffic-related air pollution) and (a) genome-wide DNA methylation and (b) gene expression in
nasal (airway) epithelium from children with asthma; 2) identify differentially DNA methylated markers or
expressed genes (by exposure level to PM2.5 or roadway) that are associated with asthma exacerbations; and
3) conduct an exploratory analysis to estimate the effects of the Environmental Protection Agency-sponsored
AQI behavioral intervention on DNA methylation and gene expression from a trial of children with asthma. Aims
1- 2 uses existing data from two completed NIH-funded studies. Aim 3 uses banked biospecimens from a pilot
randomized clinical trial of children receiving the AQI intervention on asthma action plans (i.e. clinical care).
This proposal addresses an unmet need, namely developing ‘omic’ markers of pollutant-induced asthma
exacerbations in children. Dr. Rosser’s career development plan provides for mastery of statistical genomic
methods and analyses, and builds upon clinical trial management and analysis skills. She is well positioned for
her proposed research given epidemiology background, skills with spatial modeling, and pilot data. This career
development award will provide the skills and preliminary data for an R01 seeking to test whether
epigenetic/gene markers predict risk of asthma outcomes and response to the AQI intervention.
文摘:
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Franziska Rosser其他文献
Franziska Rosser的其他文献
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{{ truncateString('Franziska Rosser', 18)}}的其他基金
Chronic outdoor air pollution, airway epithelial "omics" and asthma exacerbations in children
慢性室外空气污染、气道上皮“组学”和儿童哮喘恶化
- 批准号:
10281680 - 财政年份:2021
- 资助金额:
$ 16.03万 - 项目类别:
Chronic outdoor air pollution, airway epithelial "omics" and asthma exacerbations in children
慢性室外空气污染、气道上皮“组学”和儿童哮喘恶化
- 批准号:
10659167 - 财政年份:2021
- 资助金额:
$ 16.03万 - 项目类别:
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