ITEST: Innovative Tools to Expand Youth-Friendly HIV Self-Testing
ITEST:扩大青少年友好的艾滋病毒自我检测的创新工具
基本信息
- 批准号:10470245
- 负责人:
- 金额:$ 128.52万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-09-01 至 2023-09-01
- 项目状态:已结题
- 来源:
- 关键词:AIDS preventionAcquired Immunodeficiency SyndromeAddressAdherenceAffectAfricaAfrica South of the SaharaAfricanAmericanAnal SexAreaBehavioralBenchmarkingChlamydiaClinical Trials Data Monitoring CommitteesCommunitiesCountryCreativenessDataDecentralizationDevelopmentEffectivenessEnsureEpidemicEvaluationFrightGoalsGonorrheaGovernmentGuidelinesHIVHIV InfectionsHIV SeronegativityHuman immunodeficiency virus testIncidenceIndividualInfectionInstitutional Review BoardsInterventionLearningLinkLocal GovernmentMentorshipModalityNational Institute of Child Health and Human DevelopmentNewly DiagnosedNigeriaNigerianOutcomePatient Self-ReportPersonsPhasePoliciesPrevention strategyPreventivePreventive servicePrivacyProceduresProcessPublic HealthRandomizedRandomized Controlled TrialsRequest for ApplicationsResearchResearch PriorityRiskSamplingServicesSexually Transmitted DiseasesSocial ProblemsSocial supportSpecimenSyphilis SerodiagnosisTestingUnited States National Institutes of HealthVaginaWorld Health OrganizationYouthage groupagedapprenticeshipauthoritybasecommunity based participatory researchcondomsdesigndisparity reductioneffectiveness evaluationexperienceexperimental studyhigh riskimplementation interventionimplementation strategyimprovedinnovationlow and middle-income countriesmultidisciplinarypre-exposure prophylaxispreferencepreventprevention serviceprimary outcomerecruitresilienceresponsesecondary outcomeself testingservice uptakeskillssocialsocial stigmasuccesssupportive environmenttesting servicestherapy developmenttooltransmission processtrial readinessuptakewillingness
项目摘要
ABSTRACT
HIV incidence remains high among youth aged 14-24 in Sub-Saharan Africa, thus underscoring the
importance of interventions to prevent HIV in this age group. Nigerian youth are at the epicenter of an
expanding HIV crisis, with the second largest number of new youth HIV infections of any country. Yet fewer
than one in five Nigerian youth have ever been HIV tested. Young people are often framed as the fraught
victims of new HIV infections, instead of recognizing their resilience and power in advancing effective
response to the epidemic. Conventional expert-driven, top-down interventions have largely failed. Innovative
solutions that leverage the resourcefulness and resilience of youth are sorely needed. In this proposal, we will
develop innovative youth-friendly HIV self-testing services based on open challenges and apprenticeships
that are informed by a youth participatory action research framework. Open challenges solicit solutions from
the community and then implement the best solutions, while apprenticeship builds local capacity for youth-led
projects to increase the likelihood of success and ensure comprehensive evaluation. Three randomized
controlled trials based on open challenges have led to improved rates of HIV testing and condom use among
at-risk youth, but none of these approaches have been in Africa. These participatory approaches will be used
to identify innovative HIV self-testing strategies that meet the specific needs of Nigerian youth. Each strategy
will have a comprehensive plan for enhancing HIV prevention (including HIV pre- exposure prophylaxis and
behavioral approaches) among at-risk youth. Two HIV self-testing strategies will be selected by judges as
semi-finalists and evaluated in separate local government area pilots (UG3 phase). Once the project meets
stringent requirements demonstrating trial readiness and pilot effectiveness, a single strategy will be
evaluated in a pragmatic, cluster randomized controlled trial in 24 local government areas of Nigeria (UH3
phase). The intervention development process will build capacity for decentralized HIV self- testing, drawing
on the strengths, creativity, and engagement of Nigerian youth. Leveraging our extensive experience
organizing HIV research in Nigeria, we propose the following specific aims: (1) To use open challenges and
apprenticeship to develop new HIV self-testing services; (2) To evaluate the effectiveness of two semi-finalist
participatory interventions on HIV testing and other key prevention services among at-risk, HIV-negative
youth (14-24years old); (3) To determine the effectiveness of a finalist participatory intervention on HIV
testing and other key HIV prevention outcomes in 24 areas using a stepped wedge, pragmatic randomized
controlled trial. The overarching goal is not to create a monolithic “one-size fits all” HIV self-testing strategy,
but rather to demonstrate that open challenges can engage and inspire youth to develop innovative and
effective HIV services. Our focus on open challenges and tailoring services to youth resonates with NICHD,
NIH, and US government strategic priorities.
摘要
项目成果
期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Understanding factors that promote uptake of HIV self-testing among young people in Nigeria: Framing youth narratives using the PEN-3 cultural model.
- DOI:10.1371/journal.pone.0268945
- 发表时间:2022
- 期刊:
- 影响因子:3.7
- 作者:
- 通讯作者:
Sustaining HIV Research in Resource-Limited Settings Using PLAN (People, Learning, Adapting, Nurturing): Evidence from the 4 Youth by Youth Project in Nigeria.
- DOI:10.1007/s11904-023-00652-2
- 发表时间:2023-04
- 期刊:
- 影响因子:4.6
- 作者:
- 通讯作者:
Designing HIV Testing and Self-Testing Services for Young People in Nigeria: A Discrete Choice Experiment.
- DOI:10.1007/s40271-021-00522-2
- 发表时间:2021-11
- 期刊:
- 影响因子:0
- 作者:Ong JJ;Nwaozuru U;Obiezu-Umeh C;Airhihenbuwa C;Xian H;Terris-Prestholt F;Gbajabiamila T;Musa AZ;Oladele D;Idigbe I;David A;Okwuzu J;Bamidele T;Iwelunmor J;Tucker JD;Ezechi O
- 通讯作者:Ezechi O
Costs of implementing community-based intervention for HIV testing in sub-Saharan Africa: a systematic review.
在撒哈拉以南非洲实施基于社区的艾滋病毒检测干预措施的成本:系统评价。
- DOI:10.1186/s43058-021-00177-y
- 发表时间:2021-07-05
- 期刊:
- 影响因子:0
- 作者:Uzoaru F;Nwaozuru U;Ong JJ;Obi F;Obiezu-Umeh C;Tucker JD;Shato T;Mason SL;Carter V;Manu S;BeLue R;Ezechi O;Iwelunmor J
- 通讯作者:Iwelunmor J
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Juliet Iwelunmor其他文献
Juliet Iwelunmor的其他文献
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{{ truncateString('Juliet Iwelunmor', 18)}}的其他基金
NIAID STAR: Stimulating Training and Access to Research Experiences for Minority and Underrepresented Populations
NIAID STAR:促进少数族裔和代表性不足人群的培训和获得研究经验
- 批准号:
10686222 - 财政年份:2022
- 资助金额:
$ 128.52万 - 项目类别:
NIAID STAR: Stimulating Training and Access to Research Experiences for Minority and Underrepresented Populations
NIAID STAR:促进少数族裔和代表性不足人群的培训和获得研究经验
- 批准号:
10487949 - 财政年份:2022
- 资助金额:
$ 128.52万 - 项目类别:
ITEST: Innovative Tools to Expand Youth-Friendly HIV Self-Testing
ITEST:扩大青少年友好的艾滋病毒自我检测的创新工具
- 批准号:
10228136 - 财政年份:2018
- 资助金额:
$ 128.52万 - 项目类别:
ITEST: Innovative Tools to Expand Youth-Friendly HIV Self-Testing
ITEST:扩大青少年友好的艾滋病毒自我检测的创新工具
- 批准号:
10252954 - 财政年份:2018
- 资助金额:
$ 128.52万 - 项目类别:
Sustaining an Evidence-based Task-shifting Strategy for Blood Pressure Control in Ghana
加纳维持基于证据的血压控制任务转移策略
- 批准号:
8952757 - 财政年份:2015
- 资助金额:
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An Interdisciplinary Approach to Malaria Burden in Sub-Saharan Africa
撒哈拉以南非洲地区疟疾负担的跨学科方法
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7811434 - 财政年份:2010
- 资助金额:
$ 128.52万 - 项目类别:
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