Research Project 2

研究项目2

基本信息

  • 批准号:
    10738443
  • 负责人:
  • 金额:
    $ 23.38万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-09-19 至 2028-08-31
  • 项目状态:
    未结题

项目摘要

Every hour, over 150 people die of hepatitis-related liver diseases in African countries like Nigeria, including hepatocellular carcinoma (HCC) and other liver cancers. Much of this death is attributable to the hepatitis B virus (HBV). A hepatitis B birth dose (HepB-BD) vaccine initiated within 24 hours of birth, followed by three additional pentavalent HBV vaccines (at six, 10, and 14 weeks after birth), provide durable immunity, substantially decreasing the risk of HBV and liver cancer. Nigerian national guidelines recommend HepB-BD vaccination for all newborns and provides them for free as part of the national immunization protocol, yet uptake is suboptimal, highlighting the need for implementation science research to develop locally relevant strategies to increase HepB-BD vaccine uptake. We propose a crowdsourcing approach to enhance timely coverage of HepB-BD vaccination in Nigeria. Crowdsourcing has a group of people solve all or part of a problem, then implement selected solutions. Our team used crowdsourcing to develop messages promoting HBV testing uptake, inform global hepatitis guidelines, and enhance hepatitis community engagement in low and middle-income countries (LMICs). Our study will focus on developing and implementing strategies to increase HepB-BD vaccination at community clinics, home births, and other sites outside of hospitals where most pregnant women receive care. The Consolidated Framework for Implementation Science Research (CFIR) and concept mapping will guide our evaluation of factors influencing uptake and sustainment. Our specific aims are: 1) To determine pregnant women's preferences on HepB-BD vaccination using community-engaged crowdsourcing research and finalize an implementation strategy to increase HepB-BD vaccination; 2) To determine the effectiveness of a finalized crowdsourced HepB-BD vaccination intervention among a cohort of pregnant women using a community-based clinic-level cluster RCT. Trained community health workers will implement the final intervention in a cluster randomized control trial of the crowdsourced intervention versus standard care (i.e. printed guidelines) among a cohort of 720 dyads (pregnant women and newborns) at 36 community-based clinics (n=1440); and 3) To use mixed methods research to determine multi-level factors that influence uptake and sustainment of crowdsourced HepB-BD vaccination over time. Primary outcome is HepB-BD vaccination ascertained by clinic records. Secondary outcome is service sustainment at the community-based clinic level, defined here as the percent sustainment of core elements of the final campaign measured 12 months after the trial, with sustained benefits and capacity for implementation at each community-based clinic. Our study is responsive to the U54 request for applications for global implementation science for equitable cancer control and and the strategic priorities of the National Cancer Institute. This study will provide a unique opportunity to expand HBV vaccine coverage, driving equitable implementation science research in settings traditionally under-represented in implementation science.
在尼日利亚等非洲国家,每小时有150多人死于与肝炎有关的肝病

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Juliet Iwelunmor其他文献

Juliet Iwelunmor的其他文献

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{{ truncateString('Juliet Iwelunmor', 18)}}的其他基金

Administrative and Engagement Core
行政和参与核心
  • 批准号:
    10738440
  • 财政年份:
    2023
  • 资助金额:
    $ 23.38万
  • 项目类别:
Research Project 1
研究项目1
  • 批准号:
    10738442
  • 财政年份:
    2023
  • 资助金额:
    $ 23.38万
  • 项目类别:
Research and Capacity Building Core
研究和能力建设核心
  • 批准号:
    10738441
  • 财政年份:
    2023
  • 资助金额:
    $ 23.38万
  • 项目类别:
NIAID STAR: Stimulating Training and Access to Research Experiences for Minority and Underrepresented Populations
NIAID STAR:促进少数族裔和代表性不足人群的培训和获得研究经验
  • 批准号:
    10686222
  • 财政年份:
    2022
  • 资助金额:
    $ 23.38万
  • 项目类别:
NIAID STAR: Stimulating Training and Access to Research Experiences for Minority and Underrepresented Populations
NIAID STAR:促进少数族裔和代表性不足人群的培训和获得研究经验
  • 批准号:
    10487949
  • 财政年份:
    2022
  • 资助金额:
    $ 23.38万
  • 项目类别:
ITEST: Innovative Tools to Expand Youth-Friendly HIV Self-Testing
ITEST:扩大青少年友好的艾滋病毒自我检测的创新工具
  • 批准号:
    10228136
  • 财政年份:
    2018
  • 资助金额:
    $ 23.38万
  • 项目类别:
ITEST: Innovative Tools to Expand Youth-Friendly HIV Self-Testing
ITEST:扩大青少年友好的艾滋病毒自我检测的创新工具
  • 批准号:
    10252954
  • 财政年份:
    2018
  • 资助金额:
    $ 23.38万
  • 项目类别:
ITEST: Innovative Tools to Expand Youth-Friendly HIV Self-Testing
ITEST:扩大青少年友好的艾滋病毒自我检测的创新工具
  • 批准号:
    10470245
  • 财政年份:
    2018
  • 资助金额:
    $ 23.38万
  • 项目类别:
Sustaining an Evidence-based Task-shifting Strategy for Blood Pressure Control in Ghana
加纳维持基于证据的血压控制任务转移策略
  • 批准号:
    8952757
  • 财政年份:
    2015
  • 资助金额:
    $ 23.38万
  • 项目类别:
An Interdisciplinary Approach to Malaria Burden in Sub-Saharan Africa
撒哈拉以南非洲地区疟疾负担的跨学科方法
  • 批准号:
    7811434
  • 财政年份:
    2010
  • 资助金额:
    $ 23.38万
  • 项目类别:

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非洲罕见疾病倡议 (ARDI):通过非洲罕见疾病研究推进基因组医学
  • 批准号:
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