Research Project 1

研究项目1

基本信息

批准号：
10738442
负责人：
Juliet Iwelunmor
金额：
$ 25.55万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-19 至 2028-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10738442
关键词：
15 year old Address Affect Africa Area Awareness Behavior Cancer Control Characteristics Charge Climate Clinical Communities Community Participation Consolidated Framework for Implementation Research Country Data Death Rate Decentralization Development Dose Effectiveness Elements Eligibility Determination Equity Evaluation Evidence based intervention Friends Geography Guidelines HIV Health Health Services Human Papilloma Virus Vaccination Human Papilloma Virus Vaccine Human Papilloma Virus-Related Malignant Neoplasm Human Papillomavirus Hybrids Improve Access Incidence Individual Intervention Leadership Malignant Neoplasms Medical Research Mentorship Methods Modeling Nigeria Nigerian Policies Private Sector Randomized, Controlled Trials Records Research Research Project Grants Resources Risk Sampling Services Social support Testing Time Training Translations Vaccination Vaccines Youth aged apprenticeship cancer prevention community based participatory research community clinic community setting cost crowdsourcing effectiveness/implementation design evidence base experimental study girls implementation facilitators implementation outcomes implementation process implementation science implementation strategy implementation/effectiveness improved innovation policy recommendation post implementation preference prevent prevention service primary outcome programs recruit scale up secondary outcome self testing skills social supportive environment tool treatment as usual uptake vaccine acceptance vaccine access

项目摘要

1 Nigerians make up a significant proportion of individuals in Africa dying from human papillomavirus-(HPV) 2 associated cancers. However, they do not access essential cancer prevention services such as evidence- 3 based HPV vaccination to prevent cancer. This is partly explained by barriers that are individual (low 4 awareness), social (insufficient social support), and structural (poor access to vaccines). Implementation of 5 HPV vaccine programs can mitigate some of these barriers by decentralizing vaccine access to reduce the 6 incidence and death rate of HPV-associated cancers. We propose to expand youth-friendly HPV vaccines, 7 informed by a youth participatory action research framework (YPAR), the PEN-3 cultural model, and the 8 Consolidated Framework for Implementation Science (CFIR). Unlike projects targeting youth as passive 9 recipients, the YPAR considers youth to be partners in creating and leading solutions to problems that affect 10 them. PEN-3 cultural model leverages local resources and partnerships from an equity mindset to improve 11 health, while CFIR enables an evaluation of the barriers and facilitators of implementation effectiveness. The 12 proposed Innovative Tools to Expand youth-friendly Services and Translation of HPV services (I-TEST HPV) 13 will draw on two participatory methods, crowdsourcing (i.e., open calls and designathons) and apprenticeships, 14 to increase HPV vaccine uptake among girls aged 9-15 years old per national guidelines. We hypothesize that 15 these two approaches (open challenges and apprenticeships) will increase the uptake of HPV vaccine 16 campaigns in Nigeria. Using a hybrid type II effectiveness implementation design to simultaneously assess 17 both clinical and implementation outcomes, our aims are: 1) To use participatory approaches (crowdsourcing 18 and apprenticeships) to develop new HPV vaccine campaigns; 2) To determine whether the final 19 crowdsourced campaign increases HPV vaccination uptake among girls aged 9-15 years, and evaluate 20 intervention sustainment, one-year post implementation. We will recruit 1,120 girls from 32 communities to a 21 stepped-wedge randomized control trial of the finalist campaign versus usual care. A total of sixty-four trained 22 youth research facilitators from each setting (2 per setting) will implement the final HPV vaccination campaign. 23 The primary outcome is the initial HPV dose vaccine uptake among girls ascertained by vaccination records at 24 community clinics. The secondary outcomes include the second vaccine dose, percent sustainment of core 25 program elements with sustained benefits (uptake of HPV vaccines), and sustained capacity at participating 26 communities at one year after the trial; and 3) To use mixed-methods to explore multilevel factors that 27 influence the uptake of the HPV campaigns. This research aligns with the RFA-CA-11-019 request for research 28 and the US Cancer Moonshot Initiative. The project builds on a strong relationship with the Nigerian Institute 29 for Medical Research (NIMR) to implement a sustainable and scalable community-based model for equitable 30 cancer control. 31 32 33 34 .

1个尼日利亚人在非洲的人类乳头瘤病毒（HPV）中占非洲的很大一部分 2个相关的癌症。但是，他们无法访问基本的预防癌症预防服务，例如证据 - 3个基于HPV疫苗以预防癌症。这部分是由个人障碍解释的（低 4意识），社会（社会支持不足）和结构性（接种疫苗的不良访问）。实施 5 HPV疫苗计划可以通过分散疫苗的使用来减少这些障碍以减少这些障碍 6 HPV相关癌症的发病率和死亡率。我们建议扩大对青年友好的HPV疫苗， 7由青年参与行动研究框架（YPAR），PEN-3文化模型和 8实施科学的合并框架（CFIR）。与针对年轻人被动的项目不同 9个接收者，YPAR认为青年是为影响影响的问题创建和领导解决方案的合作伙伴 10他们。笔3文化模型利用股票思维方式从当地资源和伙伴关系来改善 11健康，而CFIR可以评估实施有效性的障碍和促进者。这提出的12个创新工具，以扩大对青年友好的服务和HPV服务的翻译（I-Test HPV） 13将利用两种参与式方法，即众包（即开放式电话和设计记者）和学徒制， 14根据国家准则增加9-15岁的女孩的HPV疫苗摄取。我们假设这一点 15这两种方法（公开挑战和学徒制）将增加HPV疫苗的摄取尼日利亚的16个运动。使用混合II型有效性实施设计同时评估 17临床和实施结果，我们的目标是：1）使用参与式方法（众包 18和学徒制）开发新的HPV疫苗活动； 2）确定最终是否 19个众包运动增加了9-15岁女孩的HPV疫苗接种摄取，并评估 20干预维持，实施一年。我们将从32个社区招募1,120名女孩 21决赛竞选活动与通常的护理的跨跨北向导随机控制试验。总共六十四个训练 22种环境中的青年研究促进者（每次环境2）将实施最终的HPV疫苗接种运动。 23主要结果是在疫苗接种记录确定的女孩中，最初的HPV剂量疫苗摄取 24个社区诊所。次要结果包括第二次疫苗剂量，核心的维持百分比 25个具有持续收益（HPV疫苗的吸收）的计划要素，并持续参与审判后一年的26个社区； 3）使用混合方法来探索多层次因素 27影响HPV运动的吸收。这项研究与RFA-CA-11-019的研究请求一致 28和美国癌症月亮倡议。该项目建立在与尼日利亚研究所建立牢固关系的基础上 29用于医学研究（NIMR），以实施可持续和可扩展的社区模型以公平 30癌症控制。 31 32 33 34。