Function Assessment Core

功能评估核心

• 批准号: 10470355
• 负责人: Roger A. Fielding
• 金额: $ 21.18万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10470355
• 关键词: Activities of Daily Living; Address; Aging; Animals; Area; Behavior; Boston; COVID-19 pandemic; Caenorhabditis elegans; Calibration; Certification; Clinical Research; Clinical Trials; Consultations; Cross-Sectional Studies; Development; Elderly; Environment; Equipment; Evaluation; Exercise Physiology; Face; Goals; Human; Human Resources; Impairment; Infection Control; Infrastructure; Intervention Studies; Leadership; Maintenance; Measurement; Measures; Movement; Muscle; Musculoskeletal; Nutritional Study; Observational Study; Older Population; Performance; Physical Function; Procedures; Protocols documentation; Quality Control; Quality of life; Research Personnel; Services; Societies; Standardization; Structure; Techniques; Technology; Training; Walking; Woman; clinical development; disability; efficacy evaluation; experience; hospital laboratories; innovation; instrument; interdisciplinary collaboration; novel; physically handicapped; preservation; procedure safety; tool; translational approach

SUMMARY / ABSTRACT Preserving late-life mobility, defined as the ability to walk safely and independently, is central to maintaining a high quality of life, is critical for the performance of many activities of daily living and is necessary for maintaining physical independence. Therefore, the continued development and standardization of tools that can reliably assess physical functioning and disability status will be important for addressing the growing challenge that societies worldwide will face with the expanding older population. The physical function assessment core seeks to continue to provide the necessary infrastructure to perform standardized, valid and reliable measures of musculoskeletal impairments, physical function, and disability across the spectrum of observational studies and clinical trials embedded within, supported by, or associated with the Boston-OIAC. The leadership of this core has collaborated extensively over the past project period, has unique experience in the application of these measurements across a wide range of cross-sectional and intervention studies in older adults, and has been on the leading edge of the development and refinement of new instruments and technologies to assess domains of physical function and disability. We propose to examine the following specific aims: Aim 1: We will provide an organized infrastructure for FAC-supported procedures and activities across Tufts’ Human Nutrition Research Center on Aging, and Brigham and Women’s Hospital Laboratory of Exercise Physiology and Physical Function and serve as focal point for interdisciplinary collaboration by OAIC investigators in the development, evaluation, and application of new and existing tools and instruments to assess musculoskeletal impairments, physical function, and disability in older adults to evaluate the efficacy of function promoting therapies. Aim 2: We will provide direct measurement and consultative services, as well as assist with proposal development for clinical studies supported by, or associated with, the theme of the OAIC that require measures of musculoskeletal impairments, physical function, and/or disability. All Core services will use standardized equipment and operating protocols for the assessment of muscle performance and functional limitations in human studies, and will maintain extensive quality control procedures including: personnel training and certification; equipment maintenance; and quality control. Aim 3: We will develop novel and innovative approaches to assess musculoskeletal impairments, physical function, and disability in older adults. The FAC will also support innovative developmental projects that seek to develop or further validate innovative approaches to assess musculoskeletal impairments, physical function, and disability in older adults.

总结/摘要 保持晚年的活动能力，定义为安全和独立行走的能力，是保持健康的核心。 高生活质量对于许多日常生活活动的表现至关重要，也是必要的 保持身体独立。因此，工具的持续发展和标准化， 能够可靠地评估身体功能和残疾状况对于解决日益增长的 这是全世界社会将面临的老年人口不断增加的挑战。物理功能 评估核心旨在继续提供必要的基础设施，以执行标准化、有效和 肌肉骨骼损伤、身体功能和残疾的可靠测量， Boston-OIAC内嵌入、支持或相关的观察性研究和临床试验。 该核心的领导层在过去的项目期间进行了广泛的合作，在以下方面拥有独特的经验： 这些测量在老年人广泛的横断面和干预研究中的应用 成年人，并一直处于发展和完善新仪器的前沿， 评估身体功能和残疾领域的技术。 我们建议审查以下具体目标： 目标1：我们将提供一个有组织的基础设施，为跨塔夫茨大学的FAC-supported程序和活动。 人类营养老化研究中心和布里格姆妇女医院运动实验室 生理学和身体功能，并作为OAIC跨学科合作的协调中心 研究人员开发、评估和应用新的和现有的工具和手段， 评估老年人的肌肉骨骼损伤、身体功能和残疾，以评估 功能促进疗法。 目标2：我们将提供直接的测量和咨询服务，并协助提出建议 由OAIC主题支持或与OAIC主题相关的需要采取措施的临床研究的开发 肌肉骨骼损伤、身体功能和/或残疾。所有核心服务将使用标准化 用于评估肌肉性能和功能限制的设备和操作方案 人类研究，并将保持广泛的质量控制程序，包括：人员培训和 认证;设备维护;质量控制。 目标3：我们将开发新的和创新的方法来评估肌肉骨骼损伤，身体 老年人的功能和残疾。FAC还将支持创新发展项目， 开发或进一步验证创新方法，以评估肌肉骨骼损伤，身体功能， 和老年人的残疾。