Fabrication and Testing of a Novel PET insert for Simultaneous PET/MRI

项目摘要。PET（正电子发射断层扫描）是最敏感的成像方式 可以同时用于小动物和人类。我们建议建立我们的工业和学术 与基于单晶管的新一代PET扫描仪（ScintoTube - ST‐PET）合作。这将 有效地去除了当前一代PET扫描仪的边缘。在边缘有扭曲 扫描仪元件，有效地降低空间分辨率和灵敏度。建议的扫描仪已 设计并将用于磁共振成像（MRI）扫描仪。这是一 学术/工业伙伴关系赠款。弗吉尼亚大学（UVa）将领导该项目。他们的伴侣 包括i3 M（CSIC-西班牙国家研究理事会）和Bruker Española。UVa团队拥有专业知识 测试/验证新型PET扫描仪、MRI软件（脉冲编程）和硬件设计， 小鼠PET和MRI扫描。I3 M及其在布鲁克的同事拥有丰富的设计专业知识， 并建立多模态扫描仪，包括Albira三模态PET/SPECT/CT鼠标扫描仪。大部分 ST‐PET扫描仪所需的技术已由i3 M/Bruker开发，并将移植为 这个项目的一部分到ST-PET。本文的主要工作包括：（1）制作高场ST-PET衬垫 核磁共振扫描仪。该插件将由i3 M和Bruker实施。测试和确认ST‐PET扫描仪 首先在i3 M处，然后在UVa处在磁体外部。(2)将ST‐PET内衬与7 T进行集成和测试 在UVa进行ClinScan MRI。(3)作为原理验证项目，使用新开发的ST‐PET/MRI进行成像 小鼠模型中的肺癌进展和转移。

Project Summary. PET (positron emission tomography) is the most sensitive imaging modality available that can be used both for small animals and humans. We propose to build with our industrial and academic partners a new generation of PET scanners based on a single crystal tube (ScintoTube – ST‐PET). This will effectively remove edges from current generation PET scanners. There are distortions at the edges of scanner elements that effectively reduce spatial resolution and sensitivity. The propose scanner has been designed and will be built to be used in a magnetic resonance imaging (MRI) scanner. This is an Academic/Industrial partnership grant. The University of Virginia (UVa) will lead the project. Their partners include i3M (CSIC ‐ Spanish National Research Council) and Bruker Española. The UVa team has expertise in testing/validating novel PET scanners, MRI software (pulse programming) and hardware design, and mouse PET and MRI scanning. I3M and their colleagues at Bruker have a wealth of expertise in designing and building multimodal scanners, including the Albira trimodal PET/SPECT/CT mouse scanner. Much of the technology needed for the ST‐PET scanner has been developed by i3M/Bruker and will be ported as part of this project to the ST‐PET. The proposed work includes: (1) Fabricate a ST‐PET insert for a high field MRI scanner. The insert will be implemented by i3M and Bruker. Test and validate the ST‐PET scanner outside the magnet first at i3M and then at UVa. (2) Integrate and test the ST‐PET insert with the 7T ClinScan MRI at UVa. (3) As a proof‐of‐principle project, use the newly developed ST‐PET/MRI to image lung cancer progression and metastasis in a mouse model.