MITS - SR Component

分子和免疫学翻译科学（MITS）-项目摘要 MITS共享资源是癌症动物模型研究的门户， 人源性材料与一套技能和分析技术，使弗吉尼亚大学癌症 中心（UVACC）成员评价研究药物对诊断或治疗的影响 癌MITS提供了访问专家的计划，培训，执行和分析实验， 运行在本共享资源内的最先进的仪器和其他UVACC中提供的仪器上- 支持共享资源。MITS仪器位于便于UVACC成员访问的位置。 仪器由专业技术人员在正常工作时间内运行， 在非黄金时段，调查员一旦完成适当培训，此共享 资源是疾病核心动物模型的扩展，在过去的一年中被评为优秀 审查.先前针对CRISPR-Cas9利用的资源审查中的次要评论 取代传统基因靶向以产生条件性敲除和敲入等位基因的技术 已经解决了。MITS在过去五年中进行了重大的设备升级，并深化了 患者来源的异种移植物（PDX）的库可供研究人员使用。MITS工作人员经常与其他 UVACC共享资源，特别是生物分子分析设施，生物统计学，高级显微镜 设施，流式细胞术核心，生物储存和组织研究设施，所有这些都有助于使MITS成为一个 高度协调和有效的临床前和临床研究的纽带。MITS也得到了学校的支持 这进一步降低了UVACC用户的成本。MITS每年由 UVACC领导和SOM研究咨询委员会，以确定所需的补贴水平， 保持收入中性的核心。MITS在价格上具有竞争力，服务交付时间迅速，并提供 保证达到或超过全国比较共享资源所设定的标准。的 为会员提供的UVACC共同支付使MITS成为具有成本效益的共享资源。

MOLECULAR AND IMMUNOLOGICAL TRANSLATIONAL SCIENCES (MITS) – PROJECT SUMMARY The MITS Shared Resource serves as a gateway for the study of both animal models of cancer and human-derived materials with a suite of skills and analytical techniques that allow University of Virginia Cancer Center (UVACC) Members to evaluate the impact of investigational agents on the diagnosis or treatment of cancer. MITS provides access to experts for planning, training, executing, and analyzing experiments that are run on state-of-the-art instrumentation within this Shared Resource and those available in other UVACC- supported Shared Resources. MITS instrumentation is located for easy access by UVACC Members. Instrumentation is run by expert technologists during normal working hours and is available for use by investigators during non-primetime hours once they have completed appropriate training. This Shared Resource is an expansion of the Animal Models of Disease Core, which was rated as Excellent during the last review. Minor comments from the previous review of the resource directed at the utilization of CRISPR-Cas9 technology to replace traditional gene targeting for creating conditional knockout and knock-in alleles have been addressed. MITS made significant equipment upgrades in the past five years and deepened the repertoire of patient-derived xenografts (PDX) available to researchers. MITS staff routinely interact with other UVACC Shared Resources, particularly the Biomolecular Analysis Facility, Biostatistics, Advanced Microscopy Facility, Flow Cytometry Core, and Biorepository and Tissue Research Facility, all of which help make MITS a nexus for highly-coordinated and efficient pre-clinical and clinical studies. MITS also is supported by the School of Medicine (SOM), which further lowers the cost for the UVACC users. MITS is reviewed annually by the UVACC leadership and the SOM Research Advisory Committee to determine the level of subsidy required to maintain a revenue neutral core. MITS is competitive in pricing, rapid in service turnout time, and provides guarantees matching or exceeding the standards set up by comparative shared resources nationally. The UVACC co-pay provided for Members makes MITS a cost-effective Shared Resource.