Trimodal PET/SPECT/CT Preclinical Scanner for Biomedical Research

用于生物医学研究的三模态 PET/SPECT/CT 临床前扫描仪

• 批准号: 9075711
• 负责人: STUART S. BERR
• 金额: $ 116.42万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-22 至 2017-09-21
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9075711
• 关键词: 10 year old; Advisory Committees; Animals; Award; Biochemical Process; Biomedical Research; Cardiac; Computer software; Cyclotrons; Data; Data Analyses; Equipment; Housing; Image; Laboratories; Magnetic Resonance Imaging; Modality; Multimodal Imaging; Nuclear; Performance; Physiologic Monitoring; Physiological; Policies; Positron-Emission Tomography; Procedures; Radiochemistry; Research Infrastructure; Research Personnel; Resolution; Rodent; Speed; Time; United States National Institutes of Health; Universities; Virginia; X-Ray Computed Tomography; attenuation; image registration; imaging modality; imaging system; in vivo; instrumentation; interest; laboratory equipment; meetings; molecular imaging; operation; optical imaging; pre-clinical; respiratory; single photon emission computed tomography

 DESCRIPTION (provided by applicant): The overarching objective of this NIH High-End Instrumentation Award application is to acquire a state- of-the-art, high-performance, integrated small-animal PET/SPECT/CT imaging system for multi-modality imaging of rodents to allow biomedical researcher at the University of Virginia (UVa) to obtain noninvasively information that without such a scanner would be impossible. This will provide investigators at UVa heretofore unachievable real-time, in vivo information on anatomical, physiological, and biochemical processes in normal and diseased animals. The specific aims of the proposed instrumentation are to: (1) Replace a 10-year old Siemens Focus 120 PET scanner with an integrated Bruker Albira PET/SPECT/CT scanner. The CT scanner will provide anatomical images and will permit attenuation corrections to be applied to the nuclear (PET and SPECT) imaging data. This scanner uses coincidence PET and collimated. There are other scanners that are available but the Albira provides the best specifications and features for the projects that are of interest to te users. The scanner has excellent sensitivity, spatial coverage and resolution, speed of acquisition, integration and registration of images between modalities, and data analysis software. We also include physiological monitoring hardware to permit the acquisition of cardiac and/or respiratory gated images. The proposed PET/SPECT/CT scanner will be housed in the existing UVa Molecular Imaging Core (UVaMIC) Laboratory. Together with a Bruker ClinScan 7T MRI, a PerkinElmer IVIS Spectrum optical imaging system, a cyclotron and radiochemistry lab, the proposed scanner will bring the multimodal imaging capabilities of the UVaMIC up to current cutting edge. The operation of the proposed equipment will be overseen by the existing UVaMIC Advisory Committee comprised of the PI, the Associate Dean for Research Infrastructure and major users across UVa. The Advisory Committee meets twice a year to review the UVaMIC and to set policies and procedures to assure equitable and maximal use of the core lab equipment.

 描述（由申请人提供）：该NIH高端仪器奖申请的总体目标是获得最先进的、高性能的、集成的小动物PET/SPECT/CT成像系统，用于啮齿动物的多模态成像，以使弗吉尼亚大学（UVa）的生物医学研究人员能够获得非侵入性信息，如果没有这样的扫描仪，这些信息是不可能的。这将为UVa的研究人员提供迄今为止无法实现的关于正常和患病动物的解剖学、生理学和生化过程的实时体内信息。所提出的仪器的具体目标是：（1）用集成的Bruker Albira PET/SPECT/CT扫描仪替换使用10年的Siemens Focus 120 PET扫描仪。CT扫描仪将提供解剖图像，并允许对核（PET和SPECT）成像数据进行衰减校正。该扫描仪使用符合PET和准直。还有其他扫描仪可供选择，但Albira为用户感兴趣的项目提供了最佳的规格和功能。该扫描仪具有出色的灵敏度、空间覆盖范围和分辨率、采集速度、模态之间图像的集成和配准以及数据分析软件。我们还包括生理监测硬件，以允许采集心脏和/或呼吸门控图像。拟议的PET/SPECT/CT扫描仪将安置在现有的UVa分子成像核心（UVaMIC）实验室。与Bruker ClinScan 7 T MRI、PerkinElmer IVIS Spectrum光学成像系统、回旋加速器和放射化学实验室一起，拟议的扫描仪将使UVaMIC的多模态成像能力达到当前的最先进水平。拟议设备的运行将由现有的UVaMIC咨询委员会监督，该委员会由PI，研究基础设施副院长和UVa的主要用户组成。咨询委员会每年举行两次会议，审查UVaMIC并制定政策和程序，以确保公平和最大限度地使用核心实验室设备。

项目成果

Effect of Osteopathic Cranial Manipulative Medicine on an Aged Rat Model of Alzheimer Disease.

• DOI: 10.7556/jaoa.2019.121
• 发表时间: 2019-10-15
• 期刊: The Journal of the American Osteopathic Association
• 作者: Tobey H;Lucas T;Bledsoe D;Mykins M;Campbell C;Berr SS;Sasser T;Helm R;Brolinson PG;Klein BG;Costa BM
• 通讯作者: Costa BM

Mechanoceutics Alters Alzheimer's Disease Phenotypes in Transgenic Rats: A Pilot Study.

机械学改变转基因大鼠阿尔茨海默病表型：一项试点研究。

• DOI: 10.3233/jad-191071
• 发表时间: 2020
• 期刊: Journal of Alzheimer's disease : JAD
• 作者: Tobey,Hope;Lucas,Tyler;Paul,Soumen;Berr,StuartS;Mehrkens,Brittney;Brolinson,PerGunnar;Klein,BradleyG;Costa,BlaiseM
• 通讯作者: Costa,BlaiseM