Trimodal PET/SPECT/CT Preclinical Scanner for Biomedical Research

 描述（由申请人提供）：本次 NIH 高端仪器奖申请的首要目标是获得最先进的、高性能、集成的小动物 PET/SPECT/CT 成像系统，用于啮齿类动物的多模态成像，使弗吉尼亚大学 (UVa) 的生物医学研究人员能够以非侵入性方式获取信息，而没有这种扫描仪就不可能获得这些信息。这将为弗吉尼亚大学的研究人员提供迄今为止无法实现的关于正常和患病动物的解剖、生理和生化过程的实时体内信息。拟议仪器的具体目标是： (1) 用集成的 Bruker Albira PET/SPECT/CT 扫描仪替换已有 10 年历史的西门子 Focus 120 PET 扫描仪。 CT 扫描仪将提供解剖图像，并允许对核（PET 和 SPECT）成像数据进行衰减校正。该扫描仪使用重合 PET 和准直。还有其他扫描仪可用，但 Albira 为用户感兴趣的项目提供了最佳规格和功能。该扫描仪具有出色的灵敏度、空间覆盖范围和分辨率、采集速度、模态之间图像的集成和配准以及数据分析软件。我们还包括生理监测硬件，以允许采集心脏和/或呼吸门控图像。拟议的 PET/SPECT/CT 扫描仪将安置在现有的 UVa 分子成像核心 (UVaMIC) 实验室中。与 Bruker ClinScan 7T MRI、PerkinElmer IVIS Spectrum 光学成像系统、回旋加速器和放射化学实验室一起，拟议的扫描仪将使 UVaMIC 的多模态成像能力达到当前最先进的水平。拟议设备的运行将由现有的 UVaMIC 咨询委员会监督，该委员会由 PI、负责研究基础设施的副院长和 UVa 的主要用户组成。咨询委员会每年举行两次会议，审查 UVaMIC 并制定政策和程序，以确保核心实验室设备的公平和最大程度的使用。

 DESCRIPTION (provided by applicant): The overarching objective of this NIH High-End Instrumentation Award application is to acquire a state- of-the-art, high-performance, integrated small-animal PET/SPECT/CT imaging system for multi-modality imaging of rodents to allow biomedical researcher at the University of Virginia (UVa) to obtain noninvasively information that without such a scanner would be impossible. This will provide investigators at UVa heretofore unachievable real-time, in vivo information on anatomical, physiological, and biochemical processes in normal and diseased animals. The specific aims of the proposed instrumentation are to: (1) Replace a 10-year old Siemens Focus 120 PET scanner with an integrated Bruker Albira PET/SPECT/CT scanner. The CT scanner will provide anatomical images and will permit attenuation corrections to be applied to the nuclear (PET and SPECT) imaging data. This scanner uses coincidence PET and collimated. There are other scanners that are available but the Albira provides the best specifications and features for the projects that are of interest to te users. The scanner has excellent sensitivity, spatial coverage and resolution, speed of acquisition, integration and registration of images between modalities, and data analysis software. We also include physiological monitoring hardware to permit the acquisition of cardiac and/or respiratory gated images. The proposed PET/SPECT/CT scanner will be housed in the existing UVa Molecular Imaging Core (UVaMIC) Laboratory. Together with a Bruker ClinScan 7T MRI, a PerkinElmer IVIS Spectrum optical imaging system, a cyclotron and radiochemistry lab, the proposed scanner will bring the multimodal imaging capabilities of the UVaMIC up to current cutting edge. The operation of the proposed equipment will be overseen by the existing UVaMIC Advisory Committee comprised of the PI, the Associate Dean for Research Infrastructure and major users across UVa. The Advisory Committee meets twice a year to review the UVaMIC and to set policies and procedures to assure equitable and maximal use of the core lab equipment.