9.4 Tesla MR Scanner for Murine Imaging

9.4 用于小鼠成像的 Tesla MR 扫描仪

• 批准号: 6803345
• 负责人: STUART S. BERR
• 金额: $ 198万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-15 至 2007-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6803345
• 关键词: atherosclerosis; biomedical equipment purchase; myocardial ischemia /hypoxia; nuclear magnetic resonance spectroscopy; stomach neoplasms

DESCRIPTION (provided by applicant): The University of Virginia Schools or Medicine and Engineering have established successful research programs in the development and application of magnetic resonance imaging (MRI) and spectroscopy (MRS) for non-invasive serial studies of the molecular mechanisms underlying ischemic heart disease (IHD), atherosclerosis, and gastric cancer in transgenic and knockout mice. Experiments to date have utilized a 4.7 Tesla MRI/MRS system, which, by current standards, is outdated in terms of field strength and gradient performance. We propose to purchase a 9.4 Telsa MRI/MRS system with state-of-the-art magnet, gradients and radio-frequency coils to enhance these lines of research. The new system is expected to provide higher signal-to-noise ratio (SNR), shorter echo times, and shorter repetition times, which would result in higher spatial, temporal, and spectral resolutions, as well as reduced scan times. These technical enhancements would be used to either improve upon existing studies or enable entirely new areas of investigation. For example, in the heart the increase in temporal resolution would not only improve the evaluation of myocardial function at rest, but would also enable the evaluation of contractile reserve during dobutamine infusion. In addition, the new system will enable us to begin studying myocardial perfusion in mouse models of IHD, and important and understudied area. Specifically, the new system will enable first-pass contrast-enhanced imaging with high spatial and temporal resolutions and improved arterial spin labeling methods. The increase in SNR and spectral resolution should also enable localized in vivo 31P MRS studies of myocardial energetics. For atherosclerosis and gastric cancer, the improvement in SNR will be used to achieve high spatial resolution for vessel wall imaging of the mouse aorta and carotid arteries, and for imaging the wall of the stomach, all of which are severely SNR limited at 4.7T. The enhanced capabilities of the new system will be brought to fruition through an existing comprehensive technical, scientific, and administrative plan.

描述（由申请人提供）：弗吉尼亚大学医学和工程学院已经在磁共振成像（MRI）和光谱学（MRS）的开发和应用方面建立了成功的研究计划，用于在转基因和基因敲除小鼠中进行缺血性心脏病（IHD）、动脉粥样硬化和胃癌潜在分子机制的非侵入性系列研究。迄今为止的实验使用了4.7特斯拉MRI/MRS系统，根据当前标准，该系统在场强和梯度性能方面已经过时。我们建议购买9.4 Telsa MRI/MRS系统，配备最先进的磁体、梯度和射频线圈，以加强这些研究领域。新系统预计将提供更高的信噪比（SNR），更短的回波时间和更短的重复时间，这将导致更高的空间，时间和频谱分辨率，以及减少扫描时间。这些技术改进将用于改进现有的研究或启用全新的调查领域。例如，在心脏中，时间分辨率的增加不仅可以改善静息时心肌功能的评价，而且还可以评价多巴酚丁胺输注期间的收缩储备。此外，新的系统将使我们能够开始研究心肌灌注在小鼠模型的IHD，和重要的和未充分研究的领域。具体而言，新系统将实现具有高空间和时间分辨率的首次通过对比增强成像以及改进的动脉自旋标记方法。SNR和光谱分辨率的增加也应该能够局部在体内31 P MRS研究心肌能量学。对于动脉粥样硬化和胃癌，SNR的改善将用于实现小鼠主动脉和颈动脉的血管壁成像以及胃壁成像的高空间分辨率，所有这些都在4.7T下受到严重的SNR限制。新系统的增强能力将通过现有的综合技术、科学和行政计划实现。

项目成果

A Novel Near-Infrared Fluorescence Imaging Probe for in Vivo Neutrophil Tracking

• DOI: 10.2310/7290.2011.00054
• 发表时间: 2012-09
• 期刊: Molecular Imaging
• 影响因子: 2.8
• 作者: Li Xiao;Yi Zhang;S. Berr;M. Chordia;P. Pramoonjago;L. Pu;D. Pan

BlobCUT: A Contrastive Learning Method to Support Small Blob Detection in Medical Imaging.

• DOI: 10.3390/bioengineering10121372
• 发表时间: 2023-11-29
• 期刊: Bioengineering (Basel, Switzerland)

Magnetic resonance imaging accurately tracks kidney pathology and heterogeneity in the transition from acute kidney injury to chronic kidney disease.

• DOI: 10.1016/j.kint.2020.08.021
• 发表时间: 2021-01
• 期刊: Kidney international
• 影响因子: 19.6
• 作者: Charlton JR;Xu Y;Wu T;deRonde KA;Hughes JL;Dutta S;Oxley GT;Cwiek A;Cathro HP;Charlton NP;Conaway MR;Baldelomar EJ;Parvin N;Bennett KM
• 通讯作者: Bennett KM

Small Blob Detector Using Bi-Threshold Constrained Adaptive Scales.

• DOI: 10.1109/tbme.2020.3046252
• 发表时间: 2021-09
• 期刊: IEEE transactions on bio-medical engineering
• 作者: Xu Y;Wu T;Charlton JR;Gao F;Bennett KM
• 通讯作者: Bennett KM

RNA-seq analyses reveal that cervical spinal cords and anterior motor neurons from amyotrophic lateral sclerosis subjects show reduced expression of mitochondrial DNA-encoded respiratory genes, and rhTFAM may correct this respiratory deficiency.

RNA-seq 分析表明，肌萎缩侧索硬化症受试者的颈脊髓和前运动神经元表现出线粒体 DNA 编码的呼吸基因表达减少，而 rhTFAM 可能会纠正这种呼吸缺陷。

• DOI: 10.1016/j.brainres.2017.05.010
• 发表时间: 2017
• 期刊: Brain research
• 影响因子: 2.9
• 作者: Ladd,AmyC;Brohawn,DavidG;Thomas,RavindarR;Keeney,PaulaM;Berr,StuartS;Khan,ShaharyarM;Portell,FranciscoR;Shakenov,MeiramZh;Antkowiak,PatrickF;Kundu,Bijoy;Tustison,Nicholas;Bennett,JamesP
• 通讯作者: Bennett,JamesP