Omic and Multidimensional Spatial Atlas of Metastatic Breast and Prostate Cancers

转移性乳腺癌和前列腺癌的组学和多维空间图谱

• 批准号: 10471933
• 负责人: JOE W. GRAY
• 金额: $ 30.8万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-19 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10471933
• 关键词: Administrator; Advisory Committees; Atlases; Benchmarking; Big Data to Knowledge; Biology; Clinical; Clinical Data; Clinical Trials; Collaborations; Communication; Communities; Computer software; Conflict (Psychology); Data; Data Analyses; Data Coordinating Center; Development; Disputes; Emerging Technologies; Ensure; Evaluation; Event; Funding; Goals; Human; Human Resources; Image; Informed Consent; Infrastructure; Institutional Review Boards; Intellectual Property; Lead; Leadership; Logistics; Malignant Neoplasms; Malignant neoplasm of prostate; Metastatic breast cancer; Microscopy; Network Infrastructure; Office of Administrative Management; Policies; Publications; Quality Control; Reporting; Research; Research Personnel; Resolution; Resource Sharing; Resources; Review Committee; Sampling; Scientific Evaluation; Site; Site Visit; System; Systems Biology; Technology; The Cancer Genome Atlas; Time; Tissues; Training; United States National Institutes of Health; Videoconferencing; Work; adjudicate; analytical tool; computational atlas; computer infrastructure; data access; data acquisition; data sharing; instrumentation; light microscopy; meetings; member; multidisciplinary; new technology; programs; quality assurance; resistance mechanism; technology development; therapy resistant; tumor; user-friendly; web site; working group

ABSTRACT - Administrative Core The Administrative Core will serve as the organization, integration, and evaluation hub of the OMS Atlas. This Core provides leadership, and supports and coordinates: (a) communications and integration within the OMS Atlas and with the Human Tumor Atlas Network (HTAN); (b) proposal management, reporting, and compliance activities; (c) oversight of budgetary and intellectual property issues; (d) unit milestone evaluation and integration, and coordination with the SMMART Clinical Trial; (e) trans-HTAN projects; (f) organization of the biomedical use case working group; (g) oversight of the OMS Atlas computational infrastructure and the Data and Resource Sharing Plan; (h) data access and publication plans, including dispute resolution; and (i) HTAN and External Advisory Committee (EAC) review. The Administrative Core will be led by Dr. Joe Gray (Contact Program Director/PI, and Characterization Unit Lead); Dr. Gordon Mills (PD/PI, SMMART Clinical Trial Director, and co-Lead Biospecimen Unit); Dr. Chris Corless (PD/PI and Lead Biospecimen Unit); Dr. Jeremy Goecks (PD/PI and Lead of the Data Analysis Unit); and Center Administrator, Dr. Heidi Feiler. Drs. Annette Kolodzie and Brett Johnson will manage integration of the SMMART clinical trial component, and biospecimen and data sharing, respectively, across the units. This Core will coordinate OMS Atlas participation in the HTAN programmatic meetings, such as HTAN Steering Committee meetings, annual Investigators meetings and site visits. For planning and evaluation, it will organize OMS Atlas meetings, including monthly unit progress meetings and Executive Committee meetings, and quarterly Steering Committee meetings, comprised of all key personnel. Meetings will be video conferenced to facilitate participation and discussion. In addition, the Administrative Core will oversee the Data and Resource Sharing Plan and development of the data networking infrastructure platform in the Analysis Unit that will integrate with the HTAN-Data Coordinating Center (HTAN- DCC) and the HTAN-Tissue Coordinating Center. The Administrative Core will coordinate publications of analyses of the OMS data that reveal specific resistance mechanisms. It will oversee trans-HTAN project development in collaboration with the OMS Atlas EAC and the HTAN. The Administrative Core will organize annual EAC meetings to provide guidance on OMS Atlas activities. This review will be coordinated with an annual retreat and HTAN site visit so the external advisors and HTAN leadership will have the opportunity to interact with researchers from all OMS Atlas sites. To facilitate collaboration, PIs from other HTAN centers, the HTAN-DCC and leaders of major cancer analysis generating programs (e.g., Cancer Systems Biology Consortium (CSBC), LINCS, PS-ON, TCGA, ICGC, BD2K, and CTD2) will also be invited. In summary, the Administrative Core will support and integrate activities between the Clinical Leads, Use Case Biology Leads, and across the Biospecimen, Characterization and Data Analysis Units, which collectively form the OMS Atlas, and coordinate these activities with tissue accrual and management through the SMMART Program.

摘要 - 行政核心 管理核心将作为 OMS Atlas 的组织、集成和评估中心。这 核心提供领导、支持和协调： (a) OMS 内的通信和集成 图谱和人类肿瘤图谱网络 (HTAN)； (b) 提案管理、报告和合规 活动; (c) 监督预算和知识产权问题； (d) 单位里程碑评估和 与 SMMART 临床试验的整合和协调； (e) 跨 HTAN 项目； (f) 组织 生物医学用例工作组； (g) 监督 OMS Atlas 计算基础设施和数据 和资源共享计划； (h) 数据访问和发布计划，包括争议解决； (i) HTAN 和外部咨询委员会 (EAC) 审查。行政核心将由 Joe Gray 博士领导（联系方式 项目总监/PI 和表征部门负责人）； Gordon Mills 博士（PD/PI、SMMART 临床试验 生物样本组主任兼联合组长）； Chris Corless 博士（PD/PI 和首席生物样本组）；杰里米博士 Goecks（PD/PI 和数据分析部门负责人）；和中心管理员 Heidi Feiler 博士。博士。安妮特 Kolodzie 和 Brett Johnson 将管理 SMMART 临床试验部分和生物样本的整合 以及各单位之间的数据共享。该核心将协调 OMS Atlas 参与 HTAN 计划性会议，例如 HTAN 指导委员会会议、年度研究者会议和现场会议 访问。为了规划和评估，它将组织 OMS Atlas 会议，包括每月的单位进度 会议和执行委员会会议，以及季度指导委员会会议，由所有人员组成 关键人员。会议将以视频方式举行，以促进参与和讨论。此外， 行政核心将监督数据和资源共享计划以及数据网络的开发 分析单元中的基础设施平台将与 HTAN 数据协调中心（HTAN- DCC）和 HTAN 组织协调中心。行政核心将协调出版物 OMS 数据分析揭示了特定的耐药机制。它将监督跨HTAN项目 与 OMS Atlas EAC 和 HTAN 合作开发。行政核心将组织 年度 EAC 会议为 OMS Atlas 活动提供指导。这项审查将与 年度静修会和 HTAN 实地考察，以便外部顾问和 HTAN 领导层将有机会 与所有 OMS Atlas 站点的研究人员互动。为了促进合作，来自其他 HTAN 中心的 PI HTAN-DCC 和主要癌症分析生成项目的领导者（例如癌症系统生物学 联盟（CSBC）、LINCS、PS-ON、TCGA、ICGC、BD2K 和 CTD2）也将受邀。综上所述， 行政核心将支持和整合临床主管、用例生物学主管、 以及生物样本、表征和数据分析单元，它们共同构成了 OMS 图集， 并通过 SMMART 计划将这些活动与组织应计和管理相协调。