Omic and Multidimensional Spatial Atlas of Metastatic Breast and Prostate Cancers

转移性乳腺癌和前列腺癌的组学和多维空间图谱

• 批准号: 10471933
• 负责人: JOE W. GRAY
• 金额: $ 30.8万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-19 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10471933
• 关键词: Administrator; Advisory Committees; Atlases; Benchmarking; Big Data to Knowledge; Biology; Clinical; Clinical Data; Clinical Trials; Collaborations; Communication; Communities; Computer software; Conflict (Psychology); Data; Data Analyses; Data Coordinating Center; Development; Disputes; Emerging Technologies; Ensure; Evaluation; Event; Funding; Goals; Human; Human Resources; Image; Informed Consent; Infrastructure; Institutional Review Boards; Intellectual Property; Lead; Leadership; Logistics; Malignant Neoplasms; Malignant neoplasm of prostate; Metastatic breast cancer; Microscopy; Network Infrastructure; Office of Administrative Management; Policies; Publications; Quality Control; Reporting; Research; Research Personnel; Resolution; Resource Sharing; Resources; Review Committee; Sampling; Scientific Evaluation; Site; Site Visit; System; Systems Biology; Technology; The Cancer Genome Atlas; Time; Tissues; Training; United States National Institutes of Health; Videoconferencing; Work; adjudicate; analytical tool; computational atlas; computer infrastructure; data access; data acquisition; data sharing; instrumentation; light microscopy; meetings; member; multidisciplinary; new technology; programs; quality assurance; resistance mechanism; technology development; therapy resistant; tumor; user-friendly; web site; working group

ABSTRACT - Administrative Core The Administrative Core will serve as the organization, integration, and evaluation hub of the OMS Atlas. This Core provides leadership, and supports and coordinates: (a) communications and integration within the OMS Atlas and with the Human Tumor Atlas Network (HTAN); (b) proposal management, reporting, and compliance activities; (c) oversight of budgetary and intellectual property issues; (d) unit milestone evaluation and integration, and coordination with the SMMART Clinical Trial; (e) trans-HTAN projects; (f) organization of the biomedical use case working group; (g) oversight of the OMS Atlas computational infrastructure and the Data and Resource Sharing Plan; (h) data access and publication plans, including dispute resolution; and (i) HTAN and External Advisory Committee (EAC) review. The Administrative Core will be led by Dr. Joe Gray (Contact Program Director/PI, and Characterization Unit Lead); Dr. Gordon Mills (PD/PI, SMMART Clinical Trial Director, and co-Lead Biospecimen Unit); Dr. Chris Corless (PD/PI and Lead Biospecimen Unit); Dr. Jeremy Goecks (PD/PI and Lead of the Data Analysis Unit); and Center Administrator, Dr. Heidi Feiler. Drs. Annette Kolodzie and Brett Johnson will manage integration of the SMMART clinical trial component, and biospecimen and data sharing, respectively, across the units. This Core will coordinate OMS Atlas participation in the HTAN programmatic meetings, such as HTAN Steering Committee meetings, annual Investigators meetings and site visits. For planning and evaluation, it will organize OMS Atlas meetings, including monthly unit progress meetings and Executive Committee meetings, and quarterly Steering Committee meetings, comprised of all key personnel. Meetings will be video conferenced to facilitate participation and discussion. In addition, the Administrative Core will oversee the Data and Resource Sharing Plan and development of the data networking infrastructure platform in the Analysis Unit that will integrate with the HTAN-Data Coordinating Center (HTAN- DCC) and the HTAN-Tissue Coordinating Center. The Administrative Core will coordinate publications of analyses of the OMS data that reveal specific resistance mechanisms. It will oversee trans-HTAN project development in collaboration with the OMS Atlas EAC and the HTAN. The Administrative Core will organize annual EAC meetings to provide guidance on OMS Atlas activities. This review will be coordinated with an annual retreat and HTAN site visit so the external advisors and HTAN leadership will have the opportunity to interact with researchers from all OMS Atlas sites. To facilitate collaboration, PIs from other HTAN centers, the HTAN-DCC and leaders of major cancer analysis generating programs (e.g., Cancer Systems Biology Consortium (CSBC), LINCS, PS-ON, TCGA, ICGC, BD2K, and CTD2) will also be invited. In summary, the Administrative Core will support and integrate activities between the Clinical Leads, Use Case Biology Leads, and across the Biospecimen, Characterization and Data Analysis Units, which collectively form the OMS Atlas, and coordinate these activities with tissue accrual and management through the SMMART Program.

抽象--管理核心 行政核心将作为OMS地图集的组织、整合和评价中心。这 CORE提供领导，并支持和协调：(A)OMS内的沟通和整合 与人类肿瘤图集网络合作；(B)提案管理、报告和遵约 活动；(C)监督预算和知识产权问题；(D)单位里程碑评价和 与SMMART临床试验的整合和协调；(E)跨Htan项目；(F)组织 生物医学用例工作组；(G)监督OMS Atlas计算基础设施和数据 和资源共享计划；(H)数据获取和公布计划，包括争议解决；和(I)Htan 和外部咨询委员会(EAC)的审查。行政核心将由Joe Gray博士领导(联系人 项目总监/PI和定性单位负责人)；Gordon Mills博士(PD/PI，SMMART临床试验 生物样品股主任和共同负责人)；Chris Corless博士(PD/PI和生物样品股负责人)；Jeremy博士 Goecks(PD/PI兼数据分析股负责人)和中心管理员Heidi Feeller博士。安妮特博士 Kolodzie和Brett Johnson将管理SMMART临床试验组件和BIOSPECIMEN的整合 以及在各个单元之间分别共享数据。该核心将协调OMS Atlas在Htan中的参与 方案会议，如Htan指导委员会会议、年度调查员会议和现场会议 来访。为了规划和评价，它将组织OMS Atlas会议，包括每月的单位进展情况 会议和执行委员会会议，以及指导委员会季度会议，由所有 关键人员。会议将举行视频会议，以方便参与和讨论。此外， 行政核心将监督数据和资源共享计划以及数据联网的发展 分析股的基础设施平台，将与Htan-数据协调中心(Htan- DCC)和Htan组织协调中心。行政核心将协调下列出版物 对OMS数据的分析揭示了特定的抗性机制。它将监督Transan-Htan项目 与OMS Atlas EAC和Htan合作开发。行政核心将组织 东非共同体年度会议，就OMS地图集活动提供指导。这项审查将与 年度务虚会和Htan现场访问，以便外部顾问和Htan领导层有机会 与所有OMS Atlas网站的研究人员互动。为了促进协作，来自其他Htan中心的PI、 Htan-DCC和主要癌症分析生成计划(例如，癌症系统生物学)的领导者 还将邀请财团(CSBC、Lincs、PS-on、TCGA、ICGC、BD2K和CTD2)。总而言之， 管理核心将支持和整合临床线索、用例生物学线索、 以及共同组成OMS地图集的生物质谱学、表征和数据分析单位， 并通过SMMART计划将这些活动与组织应计和管理协调起来。