Imaging Management and Analysis Core
影像管理和分析核心
基本信息
- 批准号:10166786
- 负责人:
- 金额:$ 20.41万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-05-01 至 2023-04-30
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalAddressAlgorithmic AnalysisAlgorithmsArchitectureBackBiological AssayBiological MarkersCell Culture TechniquesCell LineCellsCellular MorphologyCharacteristicsClassificationCollaborationsComplexComputer SystemsComputer softwareCustomDataData Storage and RetrievalDatabasesDevelopmentElectron MicroscopeElectronsEnvironmentFaceHeterogeneityHigh Performance ComputingImageImage AnalysisImaging DeviceImmunofluorescence ImmunologicIndividualInfrastructureIngestionLabelLight MicroscopeLinkMachine LearningMeasurementMeasuresMetadataMethodsMicroscopicModelingNaturePerformancePeriodicityPharmaceutical PreparationsPhenotypePopulationProceduresProcessProtocols documentationQiQuality ControlResolutionResource SharingResourcesScanning Electron MicroscopySelection CriteriaStructureSystemSystems BiologyTissuesVisualizationVisualization softwarebasecancer heterogeneitydata managementexperimental studyfeature extractionflexibilityfluorescence imaginghigh dimensionalityimage reconstructionimaging Segmentationimaging approachimaging systeminsightlight microscopymultimodalitynovelopen sourceoutreachprotocol developmentquality assurancequantitative imagingrepositoryresponsescreeningsegmentation algorithmtool
项目摘要
ABSTRACT – Imaging Management and Analysis Core
The Imaging Management and Analysis Core (Imaging Core) will meet the requirements of the three
Measuring, Modeling, and Controlling Heterogeneity-Cancer Systems Biology Consortium (M2CH-CSBC)
Projects and the Outreach Core by developing and integrating state-of-the-art resources for a complete
imaging workflow. Specifically, we will 1) use high-content imaging to measure baseline and drug and
microenvironment response phenotypes separately and in combination in a panel of cell lines, 2) optimize and
deploy novel, highly multiparameter cyclic multiplexed immunofluorescence (cmIF) imaging workflows to
measure microenvironment and drug responses in heterogeneous tissues in 2D and 3D, and 3) deploy
correlative light/electron microscopic analysis based on super-resolution light microscopy and scanning
electron microscopy to provide the ultrastructural cellular context. To execute these tasks in close collaboration
with the Projects, the Imaging Core will expand on existing resources and build a customized imaging
environment to a) acquire image data in automated ways from the multiple imaging instruments, following
precise protocols and maintaining complete metadata, b) store images and metadata and all derived and
associated measurement data in highly robust databases and repositories with powerful query, visualization,
and programmer access tools, c) quantitatively analyze images by deploying and developing state-of-the-art
image reconstruction methods, image segmentation algorithms, feature extraction and classification routines,
normalization procedures, and machine learning approaches to classify image features at multiple resolution
levels, and d) develop novel visualization methods for interacting with images and extracted features and
models in combination with experimental metadata and data from external databases.
摘要:影像管理与分析核心
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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JOE W. GRAY其他文献
JOE W. GRAY的其他文献
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{{ truncateString('JOE W. GRAY', 18)}}的其他基金
Understanding the Impact of Microscale and Nanoscale Heterogeneity and Resistance
了解微米级和纳米级异质性和阻力的影响
- 批准号:
10166790 - 财政年份:2020
- 资助金额:
$ 20.41万 - 项目类别:
Omic and Multidimensional Spatial Atlas of Metastatic Breast and Prostate Cancers
转移性乳腺癌和前列腺癌的组学和多维空间图谱
- 批准号:
9788351 - 财政年份:2018
- 资助金额:
$ 20.41万 - 项目类别:
Omic and Multidimensional Spatial Atlas of Metastatic Breast and Prostate Cancers
转移性乳腺癌和前列腺癌的组学和多维空间图谱
- 批准号:
10005913 - 财政年份:2018
- 资助金额:
$ 20.41万 - 项目类别:
Omic and Multidimensional Spatial Atlas of Metastatic Breast and Prostate Cancers
转移性乳腺癌和前列腺癌的组学和多维空间图谱
- 批准号:
10471933 - 财政年份:2018
- 资助金额:
$ 20.41万 - 项目类别:
Molecular, Cellular, and Tissue Characterization Unit
分子、细胞和组织表征单元
- 批准号:
10471935 - 财政年份:2018
- 资助金额:
$ 20.41万 - 项目类别:
Molecular, Cellular, and Tissue Characterization Unit
分子、细胞和组织表征单元
- 批准号:
10005916 - 财政年份:2018
- 资助金额:
$ 20.41万 - 项目类别:
Molecular, Cellular, and Tissue Characterization Unit
分子、细胞和组织表征单元
- 批准号:
10246896 - 财政年份:2018
- 资助金额:
$ 20.41万 - 项目类别:
Omic and Multidimensional Spatial Atlas of Metastatic Breast and Prostate Cancers
转移性乳腺癌和前列腺癌的组学和多维空间图谱
- 批准号:
10246894 - 财政年份:2018
- 资助金额:
$ 20.41万 - 项目类别:
Omic and Multidimensional Spatial Atlas of Metastatic Breast and Prostate Cancers
转移性乳腺癌和前列腺癌的组学和多维空间图谱
- 批准号:
10005901 - 财政年份:2018
- 资助金额:
$ 20.41万 - 项目类别:
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