Development and Preliminary Validation of a Bleeding Quality of Life PatientReported Outcome Measure for Older Adults

老年人出血生活质量患者报告结果测量的开发和初步验证

• 批准号: 10474623
• 负责人: Anna L Parks
• 金额: $ 15.25万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10474623
• 关键词: Affect; Age; Aging; Anticoagulant therapy; Anticoagulants; Anticoagulation; Atrial Fibrillation; Attention; Benign; Caring; Clinical Trials; Coagulation Process; Data; Decision Making; Deep Vein Thrombosis; Development; Diagnosis; Disease; Elderly; Evaluation; Event; Factor Analysis; Floor; Foundations; Future; Geriatrics; Goals; Guidelines; Health system; Hematological Disease; Hematologist; Hematology; Hemorrhage; Hemostatic function; Impaired cognition; International; Intervention; K-Series Research Career Programs; Knowledge; Measurement; Measures; Methods; Mission; Modeling; National Institute on Aging; Non-Malignant; Observational Study; Outcome; Outcome Measure; Patient Outcomes Assessments; Patient-Focused Outcomes; Patients; Perception; Persons; Physical Function; Physicians; Polypharmacy; Population; Prevention; Psychometrics; Public Health; Pulmonary Embolism; Quality of life; Questionnaires; Reporting; Research; Research Personnel; Risk; Risk Factors; Safety; Site; Societies; Standardization; Symptoms; Thrombosis; Time; Training; Transfusion; Validation; Work; clinical care; clinically relevant; cognitive interview; cohort; common treatment; design; disability; experience; falls; frailty; health care service utilization; high risk; implementation outcomes; improved; improved outcome; medical attention; multiple chronic conditions; novel; older patient; patient oriented; patient population; population health; prevent; prospective; satisfaction; therapy design; thromboembolic stroke; tool; venous thromboembolism

PROJECT SUMMARY/ABSTRACT Anticoagulation can prevent thrombosis but at the expense of increased risk of bleeding, and older age is associated with increasing risk of both thrombosis and bleeding. Older adults may be particularly vulnerable to the effects of bleeding due to the co-occurrence of risk factors like multimorbidity, disability, cognitive impairment, falls and polypharmacy. Established definitions of bleeding outcomes focus on quantification and healthcare utilization. They do not capture smaller volume bleeding that commonly affects older adults, nor do they assess the effect of anticoagulant-related bleeding on function, independence and other outcomes important to older adults. We lack a measure of anticoagulant-related bleeding in older adults that accurately reflects their experience, which in turn limits our ability to improve patient-centered outcomes. The objective of this proposal is to establish a novel patient-reported outcome measure for bleeding-related QoL for older adults taking anticoagulants. Using a cohort of older adults with atrial fibrillation or venous thromboembolism taking anticoagulants, we will pursue two aims: 1) to develop a patient-reported bleeding QoL questionnaire for older adults taking anticoagulants, and 2) to perform preliminary validation of a patient-reported bleeding QoL questionnaire for older adults taking anticoagulants. This proposal will have a significant impact by generating an outcome measure that better reflects patients’ experiences, goals and values, which can be incorporated into clinical trials and other research, clinical care, and public health and health systems interventions. This work will lead to future projects including prospective measurement of changes in QoL over time and its impact on anticoagulation decision-making, as well as design of targeted interventions to improve QoL for older adults with bleeding.

项目总结/文摘

项目成果

What Can At-home Genetic Tests Tell Me About My Health?

• DOI: 10.1001/jamainternmed.2022.0529
• 发表时间: 2022-06-01
• 期刊: JAMA INTERNAL MEDICINE
• 影响因子: 39
• 作者: Parks, Anna L.;Incze, Michael A.
• 通讯作者: Incze, Michael A.

Health-related quality of life associated with warfarin and direct oral anticoagulants in venous thromboembolism.

• DOI: 10.1016/j.thromres.2022.06.008
• 发表时间: 2022-08
• 期刊: THROMBOSIS RESEARCH
• 影响因子: 7.5
• 作者: Fang, Margaret C.;Go, Alan S.;Prasad, Priya A.;Zhou, Hui X.;Parks, Anna L.;Fan, Dongjie;Portugal, Cecilia;Sung, Sue Hee;Reynolds, Kristi
• 通讯作者: Reynolds, Kristi

Use of patient-reported outcome measures in patients with venous thromboembolism: communication from the ISTH SSC Subcommittee on Predictive and Diagnostic Variables in Thrombotic Disease.

在静脉血栓栓塞患者中使用患者报告的结果测量：ISTH SSC 血栓性疾病预测和诊断变量小组委员会的通讯。

• DOI: 10.1016/j.jtha.2023.06.023
• 发表时间: 2023
• 期刊: Journal of thrombosis and haemostasis : JTH
• 作者: deJong,CindyMM;deWit,Kerstin;Black,StephenA;Gwozdz,AdamM;Masias,Camila;Parks,AnnaL;Robert-Ebadi,Helia;Talerico,Rosa;Woller,ScottC;Klok,FrederikusA
• 通讯作者: Klok,FrederikusA

Blood Clots, or Thrombosis, in Patients With Cancer.

癌症患者的血凝块或血栓形成。

• DOI: 10.1001/jamaoncol.2022.6892
• 发表时间: 2023
• 期刊: JAMA oncology
• 影响因子: 28.4
• 作者: Litt,HenryK;Parks,AnnaL;Velazquez,AnaI
• 通讯作者: Velazquez,AnaI

Periprocedural Anticoagulation.

围手术期抗凝。

• DOI: 10.7326/aitc202304180
• 发表时间: 2023
• 期刊: Annals of internal medicine
• 影响因子: 39.2
• 作者: Parks,AnnaL;Fang,MargaretC
• 通讯作者: Fang,MargaretC