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中文摘要
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摘要 管理核心的目的是支持MSKCC的转化研究目标 作为组织中心,优化SPORE在白血病中的协作 调查人员在MSKCC内外。行政核心的具体目标是:(1)提供 有效组织、管理和协调所有教育、临床和科学活动;(2) 为SPORE的所有组成部分提供全面的集中管理和财务支持: 研究项目、核心、CRP和DEP以及与EAB和IAB的互动;以及(3)促进有效的 与所有关键的知识产权持有人沟通,包括内部和外部,包括更广泛的科学 社区,跨机构合作者,NCI,我们的患者倡导者和公众。的 行政核心将由医学博士奥马尔阿卜杜勒瓦哈卜领导,他将监督所有SPORE活动。的 行政核心还包括在财务管理、项目管理、赠款 行政、科学和医学编辑、数据管理和行政支持。的能力 集中在行政核心的服务提供以下行政和通信 为SPORE的所有组件提供服务的基础架构: ·科学监督:监测SPORE计划转化研究目标的进展, 包括评估个别项目的进度,并就以下事项作出决定: 续设/替换项目 ·财务管理:担任SPORE预算协调员和财务经理 ·编辑服务:为稿件出版和赠款协调提供编辑服务 ·赠款管理:作为国家癌症研究所的行政联络人,确保及时 提交所有必要的报告,遵守机构和联邦法规 ·数据管理系统支持:协助相关核心管理和支持SPORE相关 研究和临床数据库,以及维护一个有凝聚力和功能的数据共享计划 ·沟通:促进我们的SPORE内部以及与 白血病中的其他孢子和更广泛的科学界 ·外展:促进与公众,我们的病人倡导者和, 更广泛的患者群体,以确保SPORE临床研究以患者为中心, 促进公平获得SPORE研究的治疗 ·会议协调:组织所有与SPORE相关的务虚会和会议,并审查正在进行的 SPORE研究项目、核心项目和试点项目以及新试点项目的征集
英文摘要
ABSTRACT The purpose of the Administrative Core is to support the translational research objectives of the MSKCC SPORE in Leukemia by serving as the organizational center, optimizing collaboration among SPORE investigators within and outside MSKCC. The specific aims of the Administrative Core are (1) to provide effective organization, management, and coordination for all educational, clinical, and scientific activities; (2) to provide comprehensive centralized administrative and financial support to all the components of the SPORE: research projects, cores, CRP and DEP as well as interactions with EAB and IAB; and, (3) To foster effective communication with all key stake-holders, both intramural and extramural, including the broader scientific community, cross-institutional collaborators, the NCI, our patient advocate(s) and the general public. The Administration Core will be led by Omar Abdel-Wahab, MD, who will oversee all SPORE activities. The Administrative Core also includes personnel trained in financial management, project management, grants administration, scientific and medical editing, data management, and administrative support. The capabilities and services centralized in the Administrative Core provide the following administrative and communications infrastructure that serve all components of the SPORE: · Scientific Oversight: monitor progress of the translational research objectives of the SPORE program, including evaluating the progress of individual projects and making decisions regarding continuation/replacement projects · Financial Management: serving as the centralized SPORE budgetary coordinator and financial manager · Editorial Services: providing editorial services for manuscript publication and grants coordination · Grants Administration: serve as administrative liaison to the National Cancer Institute, ensuring the timely submission of all required reports and compliance with institutional and federal regulations · Data Management System Support: assist relevant Cores in management and support of SPORE related research and clinical databases as well as maintaining a cohesive and functional data sharing plan · Communication: foster communication and collaborative research within our SPORE as well as with other SPOREs in Leukemia and the wider scientific community · Outreach: foster effective communication with the general public, our patient advocate(s) and, the broader patient community to ensure that SPORE clinical studies are patient-centered and to promote equitable access to treatment on SPORE studies · Meetings Coordination: organize all SPORE related retreats and meetings and review of ongoing SPORE research projects, cores, and pilot projects as well as the solicitation of new pilot project
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Synthetic introns for selective targeting of RNA splicing factor-mutant leukemia
  • 批准号:
    10722782
  • 项目类别:
  • 资助金额:
    $74.86万
  • 财政年份:
    2023
  • 负责人:
    Omar Abdel-Wahab
  • 依托单位:
Charting the differentiation topology of SF3B1 mutated clonal hematopoiesis (CH) and myelodysplastic syndromes (MDS) via a multi-omics single-cell toolkit
Charting the differentiation topology of SF3B1 mutated clonal hematopoiesis (CH) and myelodysplastic syndromes (MDS) via a multi-omics single-cell toolkit
Project 3: Therapeutic inhibition of splicing through inhibition of protein arginine methylation in leukemia
  • 批准号:
    10474285
  • 项目类别:
  • 资助金额:
    $36.77万
  • 财政年份:
    2021
  • 负责人:
    Omar Abdel-Wahab
  • 依托单位:
海外基金