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中文摘要
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项目摘要/摘要 这是保罗·卡拉布雷西临床肿瘤学职业发展奖K12的续签申请 在纪念斯隆-凯特琳癌症中心继续临床转化研究培训计划 (MSK)。在我们K12计划的第一个资助期内,我们建立并执行了一个独特的 通用培训计划,扩展到所有从事癌症研究的MSK科室。该计划 向进入初级教职的高级研究员和在前3个月内进入初级教职的高级研究员征求申请 他们在MSK任职多年,以及来自其他地区培训的类似资格的候选人 通过积极的广告和节目总监的征集来招募节目。在最初的 资助期我们将资格限制为拥有医学博士学位或仅有DO学位的候选人。然而,基于 来自我们的K12外部咨询委员会(EAC)的建议,在这次续签申请中,我们有 扩大了资格范围,进一步包括拥有MD/博士和DO/博士学位的候选人。这 该计划为选定的学者提供3年的初级教师资助,旨在帮助学者过渡 成为独立的临床和翻译研究人员。这项计划的申请将是 由MSK内部和外部的该领域专家审查。经过审查的申请还包括 由K12内部咨询委员会(AC)进行评估,该委员会每年将选出3-4名最佳申请者。 额外的配套机构资金已经允许并将继续允许该计划支持 每年最多4名新学者,在资助期间的任何给定时间最多资助12名学者 句号。由咨询委员会挑选的学者的申请随后将由 成立K12教育委员会(EC),将为每个被选中的人设计个性化的课程 候选人。本课程将包括预先设定的核心课程,这是所有具有 附加选修课来自路易斯.V.格斯特纳研究生院提供的课程。 生物医学科学。值得注意的是,在第一个K12资助期内,我们成功地建立了 研究生院临床和转化性癌症研究硕士课程。所有学者都会 有权选择通过额外的选修课程获得足够的学分以获得该学位。 通过书面问卷,K12学者将被要求审查该计划并提供进展情况 每年报告一次。为了进一步评估K12计划的进展和功能,学者们将提供 对他们导师的书面评估,就像导师会对学者的进步提供书面评估一样 每两年一次。K12计划将共同利用这些书面评估来评估 学者的进步,导师的健康,以及项目的整体表现。该计划和 奖学金的进展将由K12咨询委员会和选管会每两年评估一次,其中将包括选管会 在一年一度的K12研究研讨会期间进行一次现场参观。
英文摘要
PROJECT SUMMARY/ABSTRACT This is a renewal K12 application for the Paul Calabresi Career Development Award for Clinical Oncology to continue a training program for clinical translational research at Memorial Sloan Kettering Cancer Center (MSK). Over the first funding period of our K12 program we have established and executed a uniquely universal training program which extends to all MSK departments engaged in cancer research. The program solicits applications from senior fellows moving into junior faculty positions and junior faculty within the first 3 years of their appointments at MSK as well as similarly qualified candidates from other regional training programs recruited through aggressive advertisement and solicitation of program directors. During the initial funding period we restricted eligibility to candidates with an MD or DO degree alone. However, based on recommendations from our K12 external advisory committee (EAC), in this renewal application we have expanded eligibility to further include candidates holding combined MD/PhD and DO/PhD degrees. This program provides 3 years of junior faculty funding to selected scholars, and aims to help scholars transition into becoming independent clinical and translational investigators. Applications for this program will be reviewed by experts in the field both from within and outside of MSK. Reviewed applications are further evaluated by the K12 internal advisory committee (AC) which will select the 3-4 best applicants annually. Additional matching institutional funding has allowed and will continue to allow the program to support a maximum of 4 new scholars annually with up to 12 scholars funded at any given time during the funding period. Applications from scholars selected by the advisory committee will subsequently be evaluated by an established K12 educational committee (EC) who will design a personalized curriculum for each selected candidate. This curriculum will include a pre-established core curriculum requisite for all scholars with additional elective courses derived from available courses offered by the Louis V. Gerstner Graduate School of Biomedical Science. Significantly, over the first K12 funding period we have successfully established a Master's program in Clinical and Translational Cancer Research within the graduate school. All scholars will have the option to obtain sufficient credits through additional elective courses to be awarded this degree. Through written questionnaires K12 scholars will be asked to review the program and provide a progress report annually. In order to further assess the progress and function of the K12 program, scholars will provide written evaluations of their mentors as will mentors provide written evaluations of the scholar's progression on a biannual basis. Collectively these written evaluations will be utilized by the K12 program to assess the scholar's progress, the mentor's fitness, and the overall performance of the program. The program and scholar progress will be evaluated biannually by the K12 AC as well as the EAC which will include for the EAC one onsite visit during the annual K12 research symposium.
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Synthetic introns for selective targeting of RNA splicing factor-mutant leukemia
  • 批准号:
    10722782
  • 项目类别:
  • 资助金额:
    $74.86万
  • 财政年份:
    2023
  • 负责人:
    Omar Abdel-Wahab
  • 依托单位:
Charting the differentiation topology of SF3B1 mutated clonal hematopoiesis (CH) and myelodysplastic syndromes (MDS) via a multi-omics single-cell toolkit
Charting the differentiation topology of SF3B1 mutated clonal hematopoiesis (CH) and myelodysplastic syndromes (MDS) via a multi-omics single-cell toolkit
Project 3: Therapeutic inhibition of splicing through inhibition of protein arginine methylation in leukemia
  • 批准号:
    10474285
  • 项目类别:
  • 资助金额:
    $36.77万
  • 财政年份:
    2021
  • 负责人:
    Omar Abdel-Wahab
  • 依托单位:
海外基金