权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Motion Processing in the Superior Colliculus

上丘的运动处理

基本信息

批准号：
10474440
负责人：
Jianhua Cang
金额：
$ 36.3万
依托单位：
UNIVERSITY OF VIRGINIA
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-12-01 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10474440
关键词：
Affect Animals Area Behavior Behavioral Brain Calcium Data Disease Dyslexia Environment Foundations Genetic Goals Grant Head Image Individual Location Locomotion Maps Mediating Mental disorders Methodology Midbrain structure Modeling Motion Motor Movement Mus Nervous system structure Neurons Physiological Preparation Process Property Research Research Personnel Retina Running Schizophrenia Sensory Series Signal Transduction Speed Stimulus Synapses System Transgenic Mice Vertebrates Viral Vision Vision research Visual Visual Cortex Visual system structure Whole-Cell Recordings autism spectrum disorder awake brain circuitry cell type excitatory neuron experimental study ganglion cell in vivo inhibitory neuron insight multimodality nervous system disorder neural circuit neuromechanism novel object motion optic flow optogenetics receptive field relating to nervous system response retinotopic sensory system signal processing superior colliculus Corpora quadrigemina tool treadmill two-photon virtual reality environment virtual reality system visual information visual processing visual stimulus

项目摘要

Project Summary/Abstract How visual information is processed and transformed in the nervous system is a fundamental question in vision research. Given its clear importance in visually-guided behaviors and the available genetic tools, the mouse superior colliculus (SC) holds great promise for understanding visual processing and its neural mechanisms. The SC is a midbrain structure important for multimodal integration and sensorimotor transformation. Its superficial layers are purely visual and receive direct inputs from the retina. In this proposal, the investigators will study motion processing in a visual layer of the SC, the SGS, with a particular focus on its modulation by stimulus context, locomotion state, and self-generated visual flow. First, in vivo whole cell recording will be performed to determine the synaptic inputs that individual SGS neurons receive from the region surrounding their receptive fields. These experiments will reveal the local connectivity of excitatory and inhibitory neurons that mediates the bidirectional encoding of motion contrast between the visual stimulus and its context. Second, two-photon calcium imaging will be performed in awake mice to determine whether and how locomotion affects visual responses in the SGS. These experiments will be done across the depth of the SGS and in a cell- type-specific manner. Finally, the investigators will study whether and how self-generated visual flow affects the responses of SGS neurons. Two-photon imaging and physiological recording will be performed in head- restrained mice running in a virtual reality system. These experiments will be conducted across different retinotopic locations in the SGS, in order to reveal whether a region-specific organization exists in the SGS in the context of encoding self-generated motion. Together, these experiments will generate important data needed for a complete understanding of visual processing in the brain. Because normal visual processing is compromised in a number of neurological and psychiatric disorders, such as dyslexia, schizophrenia, and autism spectrum disorders, these studies will provide novel insights for the understanding and treatment of these disorders.

项目总结/文摘

项目成果

期刊论文数量（27）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Retinal origin of direction selectivity in the superior colliculus.

上丘方向选择性的视网膜起源

DOI：
10.1038/nn.4498
发表时间：
2017-04
期刊：
Nature neuroscience
影响因子：
25
作者：
Shi X;Barchini J;Ledesma HA;Koren D;Jin Y;Liu X;Wei W;Cang J
通讯作者：
Cang J

In vivo imaging of the inner retinal layer structure in mice after eye-opening using visible-light optical coherence tomography.

DOI：
10.1016/j.exer.2021.108756
发表时间：
2021-10
期刊：
EXPERIMENTAL EYE RESEARCH
影响因子：
3.4
作者：
Beckmann, Lisa;Cai, Zhen;Cole, James;Miller, David A.;Liu, Mingna;Grannonico, Marta;Zhang, Xian;Ryu, Hyun Jung;Netland, Peter A.;Liu, Xiaorong;Zhang, Hao F.
通讯作者：
Zhang, Hao F.

Rapid development of motion-streak coding in the mouse visual cortex.