Limited Competition for the Continuation of the Intestinal Stem Cell Consortium Coordinating Center

项目概要/摘要 肠道干细胞联盟协调中心（ISCC CC）的总体目标是最大限度地提高 科学交流和加速研究，信息，数据，生物材料，模型，试剂，资源 以及在ISCC内部和与研究界共享的方法。这项拨款提案的目标是 在未来5年内，继续维持和加强City of Hope的ISCC CC， 来自全国9个研究中心的调查人员被NIH选中， 靶向肠干细胞及其支持生态位的治疗，以再生和重建人类肠道。 为了实现其使命的特点，最小的，所需的生态位因素，支持肠道干细胞， ISCC采用综合的、多学科的团队科学方法， 协同项目网络侧重于以下3个目标： 目标2：确定改变的生态位组分， 在损伤（感染、化疗、放疗）后，评估它们是否在上皮细胞中发挥作用。 目标3：开发上皮损伤的治疗方法，使用移植，药物，生长 和/或差异化因素。COH的ISCC CC完全准备好继续提供最佳研究 通过以下具体目标为ISCC提供基础设施和支持：1）促进必要的团队 科学管理的ISCC; 2）通过提供研究，促进ISCC的合作科学 开发和分析; 3）协调整个联盟的标准化资源;以及4）提供 ISCC内部和整个研究界的数据和信息共享。

PROJECT SUMMARY/ ABSTRACT The overall objective of the Intestinal Stem Cell Consortium Coordinating Center (ISCC CC) is to maximize scientific exchange and accelerate research, information, data, biomaterials, models, reagents, resources and methods shared within the ISCC and with the research community. The goal of this grant proposal is to continue to maintain and enhance the ISCC CC at City of Hope for another 5 years, working with investigators from 9 Research Centers across the nation chosen by NIH to pursue the vision of developing novel therapies targeting intestinal stem cells and their supportive niche to regenerate and rebuild the human intestine. To achieve its mission of characterizing the minimal, required niche factors that support intestinal stem cells in health and disease, the ISCC utilizes an integrated, multidisciplinary team science approach, which is a network of synergistic projects focused on the following 3 Goals: Goal 1: To define essential niche components that contribute to intestinal epithelial homeostasis, Goal 2: To determine niche components that are altered following injury (infection, chemotherapy, radiation) and evaluate whether they play a role in epithelial regeneration, and Goal 3: To develop a therapeutic approach for epithelial injury, using transplant, drugs, growth and/or differentiating factors. The ISCC CC at COH is fully poised to continue to provide optimal research infrastructure and support to the ISCC through the following specific aims: 1) To facilitate the necessary team science administration of the ISCC; 2) To advance the collaborative science of the ISCC by providing study development and analysis; 3) To coordinate standardized resources across the Consortium; and 4) To provide data and information sharing within the ISCC and across the research community.