Human Islet Research Network (HIRN) Coordinating Center

人类胰岛研究网络 (HIRN) 协调中心

• 批准号: 9081590
• 负责人: Joyce Carol Niland
• 金额: $ 100万
• 依托单位: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-15 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9081590
• 关键词: Advisory Committees; Beta Cell; Biocompatible Materials; Bioinformatics; Biological; Biomedical Research; Cataloging; Catalogs; Cell Line; Cities; Collaborations; Communication; Communities; Data; Databases; Development; Diabetes Mellitus; Digestive System Disorders; Doctor of Philosophy; Electronics; Ensure; Environment; Familiarity; Fostering; Funding; Future; Goals; Growth; Health; Human; Imagery; Information Resources; Information Sciences; Information Systems; Institutes; Insulin-Dependent Diabetes Mellitus; Investments; Kidney Diseases; Knowledge; Leadership; Link; Metadata; Mission; Monitor; Multicenter Studies; N.I.H. Research Support; National Institute of Diabetes and Digestive and Kidney Diseases; Network Infrastructure; Office of Administrative Management; Online Systems; Participant; Policies; Prevention; Principal Investigator; Procedures; Process; Qualifying; Reagent; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resources; Role; Science; Scientific Advances and Accomplishments; Scientist; Support System; Teleconferences; Tissue Donors; Translational Research; Trust; U-Series Cooperative Agreements; United States National Institutes of Health; Work; base; collaborative environment; data sharing; experience; flexibility; forging; functional loss; induced pluripotent stem cell; innovation; islet; material transfer agreement; meetings; member; next generation; operation; professor; programs; repository; software systems; success; tool; treatment strategy; web site; working group

 DESCRIPTION (provided by applicant): City of Hope (COH) is applying to serve as the Human Islet Research Network (HIRN) Coordinating Center (HIRN-CC), to support HIRN's goal of developing innovative strategies for the treatment, prevention and cure of Type 1 Diabetes (T1D). The HIRN-CC will provide critical infrastructure to promote communication and collaboration among current and future HIRN participants, facilitating scientific advances and fostering the sharing of data, tools, and reagents among HIRN members and the research community at large. To support the HIRN mission, the HIRN-CC will work collaboratively with the HIRN Bioinformatics Center (HIRN-BC) to form the HIRN Administrative Hub, under the guidance of the HIRN advisory committees and National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Our highly qualified Principal Investigator (PI) and staff will apply their extensive experience with administrative management of resource-based operations serving the biomedical research community, leveraging ongoing NIDDK support to optimize the value to the HIRN, incorporating our familiarity with the UC4 cooperative mechanism, and a diverse portfolio of successfully deployed biomedical research support systems, websites, and multi-center databases. Through the HIRN-CC, COH will provide an optimal administrative infrastructure for the HIRN, including arranging all meetings and teleconferences of the multiple advisory groups; preparing agendas, meeting materials and drafting minutes; documenting policies and procedures for the program; and issuing "opportunity pool" subcontracts. COH will foster an environment of trust and cooperation among participating HIRN consortia members to maximize information and resource sharing, thereby accelerating team science and new advances. The CC will actively facilitate scientific communication through organization of an annual scientific retreat, encouraging discussion among participating investigators via 'chat' rooms, facilitating working groups, and networking and collaborations among other NIH programs and non-NIH partners. In establishing a strong collaborative with the HIRN-BC, COH will promote sharing of data, materials and resources across the HIRN Consortia and the T1D scientific community through development of a leading edge HIRN website and data repository linkage. HIRN consortia members will benefit by cataloguing, searching, and exchanging biomaterials via the COH-developed electronic Material Transfer Agreement (eMTA) software system, facilitating streamlined transfer of materials among Consortia membership. The CC will develop search and visualization tools for investigators to readily access validated data and metadata generated by HIRN research projects, and link HIRN databases to relevant NIH data repositories and websites to eliminate duplication. The HIRN-CC will forge partnerships with related initiatives such as the Integrated Islet Distribution Program (IIDP) to leverage existing resources. COH is fully poised to assume all HIRN-CC responsibilities to support and enhance the HIRN initiative, while remaining flexible in accommodating the changing TID scientific environment and emerging research needs.

 描述（由适用提供）：希望之城（COH）申请作为人类胰岛研究网络（HIRN）协调中心（HIRN-CC），以支持HIRN为1型糖尿病类型（T1D）制定创新的治疗，预防和治疗的创新策略的目标。 HIRN-CC将提供关键的基础设施，以促进当前和未来的HIRN参与者之间的沟通和协作，支持科学进步并促进HIRN成员和整个研究社区之间数据，工具和试剂的共享。为了支持HIRN任务，HIRN-CC将在HIRN咨询承诺和国家糖尿病研究所，消化和消化和肾脏疾病（NIDDK）的指导下，在HIRN咨询承诺和国家咨询研究所的指导下，将与HIRN BioInformatics Center（HIRN-BC）合作形成HIRN行政枢纽。我们高素质的首席研究员（PI）和员工将在为生物医学研究社区提供基于资源的运营的行政管理方面运用他们的丰富经验，并利用正在进行的NIDDK支持优化了HIRN的价值，影响了我们对UC4合作机构的熟悉程度，以及成功地部署生物跨性别研究支持系统和跨越的多元化投资组合。通过HIRN-CC，COH将为HIRN提供最佳的行政基础设施，包括安排多个咨询小组的所有会议和电信；准备议程，会议材料和起草会议分钟；记录该计划的政策和程序；并发行“机会池”分包。 COH将在参与的HIRN财团成员之间促进一个信任与合作的环境，以最大程度地提高信息和资源共享，从而加速团队科学和新的进步。 CC将通过组织年度科学务虚会来积极促进科学沟通，通过“聊天”室在参与调查人员之间进行讨论，支持工作组，以及其他NIH计划和非NIH合作伙伴的网络和协作。在与HIRN-BC建立强大的合作时，COH将通过开发领先的HIRN网站和数据存储库链接来促进整个HIRN财团和T1D科学界的数据，材料和资源的共享。 HIRN Consortia成员将通过COH开发的电子材料转移协议（EMTA）软件系统进行编目，搜索和交换生物材料，从而受益，从而支持财团会员资格中材料的简化转移。 CC将开发搜索和可视化工具，供研究人员容易访问由HIRN研究项目生成的经过验证的数据和元数据，并将HIRN数据库与相关的NIH数据存储库和网站链接起来，以消除重复。 HIRN-CC将与相关计划（例如集成胰岛分销计划（IIDP））建立合作伙伴关系，以利用现有资源。 COH完全中毒，承担所有HIRN-CC的责任，以支持和增强HIRN倡议，同时还可以灵活地利用不断变化的TID科学环境和新兴的研究需求。