Human Islet Research Network (HIRN) Coordinating Center

 描述（由申请人提供）：City of Hope（COH）正在申请担任人类胰岛研究网络（HIRN）协调中心（HIRN-CC），以支持HIRN开发1型糖尿病（T1 D）治疗，预防和治愈创新策略的目标。HIRN-CC将提供关键的基础设施，以促进当前和未来的HIRN参与者之间的沟通与合作，促进科学进步，并促进HIRN成员和整个研究界之间的数据，工具和试剂共享。为了支持HIRN的使命，HIRN-CC将与HIRN生物信息学中心（HIRN-BC）合作，在HIRN咨询委员会和国家糖尿病、消化和肾脏疾病研究所（NIDDK）的指导下，组建HIRN行政中心。我们高素质的主要研究者（PI）和工作人员将运用他们在服务于生物医学研究社区的资源型运营的行政管理方面的丰富经验，利用持续的NIDDK支持来优化HIRN的价值，结合我们对UC 4合作机制的熟悉，以及成功部署的生物医学研究支持系统，网站和多中心数据库的多样化组合。通过HIRN-CC，COH将为HIRN提供最佳的行政基础设施，包括安排多个咨询小组的所有会议和电话会议;准备议程，会议材料和起草会议记录;记录计划的政策和程序;以及发布“机会池”分包合同。COH将在参与HIRN联盟成员之间营造信任与合作的环境，以最大限度地实现信息和资源共享，从而加速团队科学和新的进步。CC将通过组织年度科学务虚会积极促进科学交流，鼓励参与研究者通过“聊天室”进行讨论，促进工作组，以及其他NIH项目和非NIH合作伙伴之间的网络和合作。在与HIRN-BC建立强有力的合作关系时，COH将通过开发领先的HIRN网站和数据存储库链接，促进HIRN联盟和T1 D科学界之间的数据、材料和资源共享。HIRN联盟成员将通过COH开发的电子材料转让协议（eMTA）软件系统对生物材料进行编目、搜索和交换，从而促进联盟成员之间的材料转让。CC将为研究人员开发搜索和可视化工具，以便随时访问HIRN研究项目生成的验证数据和元数据，并将HIRN数据库与相关NIH数据库和网站链接，以消除重复。HIRN-CC将与综合胰岛分配计划（IIDP）等相关倡议建立伙伴关系，以利用现有资源。COH完全准备好承担所有HIRN CC的责任，以支持和加强HIRN计划，同时保持灵活性，以适应不断变化的TID科学环境和新兴的研究需求。

 DESCRIPTION (provided by applicant): City of Hope (COH) is applying to serve as the Human Islet Research Network (HIRN) Coordinating Center (HIRN-CC), to support HIRN's goal of developing innovative strategies for the treatment, prevention and cure of Type 1 Diabetes (T1D). The HIRN-CC will provide critical infrastructure to promote communication and collaboration among current and future HIRN participants, facilitating scientific advances and fostering the sharing of data, tools, and reagents among HIRN members and the research community at large. To support the HIRN mission, the HIRN-CC will work collaboratively with the HIRN Bioinformatics Center (HIRN-BC) to form the HIRN Administrative Hub, under the guidance of the HIRN advisory committees and National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Our highly qualified Principal Investigator (PI) and staff will apply their extensive experience with administrative management of resource-based operations serving the biomedical research community, leveraging ongoing NIDDK support to optimize the value to the HIRN, incorporating our familiarity with the UC4 cooperative mechanism, and a diverse portfolio of successfully deployed biomedical research support systems, websites, and multi-center databases. Through the HIRN-CC, COH will provide an optimal administrative infrastructure for the HIRN, including arranging all meetings and teleconferences of the multiple advisory groups; preparing agendas, meeting materials and drafting minutes; documenting policies and procedures for the program; and issuing "opportunity pool" subcontracts. COH will foster an environment of trust and cooperation among participating HIRN consortia members to maximize information and resource sharing, thereby accelerating team science and new advances. The CC will actively facilitate scientific communication through organization of an annual scientific retreat, encouraging discussion among participating investigators via 'chat' rooms, facilitating working groups, and networking and collaborations among other NIH programs and non-NIH partners. In establishing a strong collaborative with the HIRN-BC, COH will promote sharing of data, materials and resources across the HIRN Consortia and the T1D scientific community through development of a leading edge HIRN website and data repository linkage. HIRN consortia members will benefit by cataloguing, searching, and exchanging biomaterials via the COH-developed electronic Material Transfer Agreement (eMTA) software system, facilitating streamlined transfer of materials among Consortia membership. The CC will develop search and visualization tools for investigators to readily access validated data and metadata generated by HIRN research projects, and link HIRN databases to relevant NIH data repositories and websites to eliminate duplication. The HIRN-CC will forge partnerships with related initiatives such as the Integrated Islet Distribution Program (IIDP) to leverage existing resources. COH is fully poised to assume all HIRN-CC responsibilities to support and enhance the HIRN initiative, while remaining flexible in accommodating the changing TID scientific environment and emerging research needs.