Limited Competition for the Continuation of the Intestinal Stem Cell Consortium Coordinating Center

肠干细胞联盟协调中心延续有限竞争

基本信息

批准号：
10229484
负责人：
Joyce Carol Niland
金额：
$ 40.59万
依托单位：
BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-30 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10229484
关键词：
Affect Applications Grants Biocompatible Materials Biometry Cells Chemotherapy and/or radiation Cities Collaborations Collection Communities Data Data Analyses Data Set Development Digestive System Disorders Disease Ensure Fostering Fruit Funding Gastrointestinal Diseases Gastrointestinal tract structure Goals Growth Factor Health Homeostasis Human Image Infection Injury Intestines Investigation Knowledge Lead Maintenance Methods Mission Modeling Natural regeneration Online Systems Patients Pharmaceutical Preparations Pilot Projects Play Policies Population Protocols documentation Publications RNA Interference Reagent Regenerative capacity Research Research Design Research Infrastructure Research Personnel Research Project Grants Research Support Resource Sharing Resources Role Sample Size Science Scientific Advances and Accomplishments Standardization Stem Cell Research Teleconferences Therapeutic Time Transplantation United States National Institutes of Health Vision data resource data tools design epithelial injury epithelium regeneration experience gastrointestinal system intestinal epithelium meetings member morphogens multidisciplinary new therapeutic target preclinical study programs regeneration potential stem cell biology stem cells web site working group

项目摘要

PROJECT SUMMARY/ ABSTRACT The overall objective of the Intestinal Stem Cell Consortium Coordinating Center (ISCC CC) is to maximize scientific exchange and accelerate research, information, data, biomaterials, models, reagents, resources and methods shared within the ISCC and with the research community. The goal of this grant proposal is to continue to maintain and enhance the ISCC CC at City of Hope for another 5 years, working with investigators from 9 Research Centers across the nation chosen by NIH to pursue the vision of developing novel therapies targeting intestinal stem cells and their supportive niche to regenerate and rebuild the human intestine. To achieve its mission of characterizing the minimal, required niche factors that support intestinal stem cells in health and disease, the ISCC utilizes an integrated, multidisciplinary team science approach, which is a network of synergistic projects focused on the following 3 Goals: Goal 1: To define essential niche components that contribute to intestinal epithelial homeostasis, Goal 2: To determine niche components that are altered following injury (infection, chemotherapy, radiation) and evaluate whether they play a role in epithelial regeneration, and Goal 3: To develop a therapeutic approach for epithelial injury, using transplant, drugs, growth and/or differentiating factors. The ISCC CC at COH is fully poised to continue to provide optimal research infrastructure and support to the ISCC through the following specific aims: 1) To facilitate the necessary team science administration of the ISCC; 2) To advance the collaborative science of the ISCC by providing study development and analysis; 3) To coordinate standardized resources across the Consortium; and 4) To provide data and information sharing within the ISCC and across the research community.

项目摘要/摘要肠道干细胞联盟协调中心（ISCC CC）的总体目标是最大化科学交流和加速研究，信息，数据，生物材料，模型，试剂，资源以及在ISCC和研究界共享的方法。该赠款提议的目标是继续在希望之城维持和增强ISCC CC，与之合作5年 NIH选出的全国9个研究中心的调查人员追求发展新颖的愿景靶向肠道干细胞及其支持的利基市场的疗法可再生和重建人类肠道。为了实现其表征最低限度的使命，所需的利基因素支持肠道干细胞中的肠道细胞健康与疾病，ISCC使用了一种综合的，多学科的团队科学方法，这是一种协同项目的网络重点介绍以下3个目标：目标1：定义基本的小众组件这有助于肠上皮稳态，目标2：确定改变的小众组件受伤后（感染，化学疗法，放射线），并评估它们是否在上皮中起作用再生和目标3：使用移植，药物，生长开发上皮损伤的治疗方法和/或区分因素。 COH的ISCC CC已完全准备继续提供最佳研究通过以下特定目标：1）促进必要的团队，对ISCC的基础架构和支持 ISCC科学管理； 2）通过提供研究来推进ISCC的协作科学开发和分析； 3）协调整个财团的标准化资源； 4）提供 ISCC和整个研究社区内的数据和信息共享。