Limited Competition for the Continuation of the Intestinal Stem Cell Consortium Coordinating Center

项目摘要/摘要 肠干细胞协调中心(ISCC CC)的总体目标是最大限度地 科学交流，加速研究、信息、数据、生物材料、模型、试剂、资源 以及在ISCC内部和与研究界共享的方法。这项拨款提案的目标是 继续在希望之城维护和加强ISCC CC 5年，与 来自全国9个研究中心的研究人员被美国国立卫生研究院选中追求小说发展的愿景 针对肠道干细胞及其支持的利基细胞的治疗，以再生和重建人类肠道。 为了完成其任务，即确定支持肠道干细胞的最低限度、所需的利基因子 关于健康和疾病，ISCC使用综合的、多学科的团队科学方法，这是一种 协同项目网络侧重于以下3个目标：目标1：确定基本的利基组成部分 有助于肠上皮细胞动态平衡的基因，目标2：确定被改变的生态位成分 损伤后(感染、化疗、放疗)，并评估它们是否在上皮细胞中起作用 再生和目标3：开发一种治疗上皮损伤的方法，使用移植、药物、生长 和/或区分因素。COH的ISCC CC完全准备好继续提供最佳研究 通过以下具体目标为ISCC提供基础设施和支持：1)为必要的团队提供便利 ISCC的科学管理；2)通过提供研究来促进ISCC的合作科学 开发和分析；3)协调整个联合体的标准化资源；以及4)提供 ISCC内部和整个研究界的数据和信息共享。

PROJECT SUMMARY/ ABSTRACT The overall objective of the Intestinal Stem Cell Consortium Coordinating Center (ISCC CC) is to maximize scientific exchange and accelerate research, information, data, biomaterials, models, reagents, resources and methods shared within the ISCC and with the research community. The goal of this grant proposal is to continue to maintain and enhance the ISCC CC at City of Hope for another 5 years, working with investigators from 9 Research Centers across the nation chosen by NIH to pursue the vision of developing novel therapies targeting intestinal stem cells and their supportive niche to regenerate and rebuild the human intestine. To achieve its mission of characterizing the minimal, required niche factors that support intestinal stem cells in health and disease, the ISCC utilizes an integrated, multidisciplinary team science approach, which is a network of synergistic projects focused on the following 3 Goals: Goal 1: To define essential niche components that contribute to intestinal epithelial homeostasis, Goal 2: To determine niche components that are altered following injury (infection, chemotherapy, radiation) and evaluate whether they play a role in epithelial regeneration, and Goal 3: To develop a therapeutic approach for epithelial injury, using transplant, drugs, growth and/or differentiating factors. The ISCC CC at COH is fully poised to continue to provide optimal research infrastructure and support to the ISCC through the following specific aims: 1) To facilitate the necessary team science administration of the ISCC; 2) To advance the collaborative science of the ISCC by providing study development and analysis; 3) To coordinate standardized resources across the Consortium; and 4) To provide data and information sharing within the ISCC and across the research community.