Pathobiology of Occlusive Vascular Disease

这一A1重新提交是为了继续进行#年的多学科博士后研究培训计划。 心血管科学，每年支持六名(MD，DDS，DVM，PhD)研究员。该计划有一个 在过去的40年里，成功地培养了年轻的科学家和未来的领导者，这是一个丰富而持续的记录。的 在过去十年中，95%(37/39)的受训者目前在科学/医学领域；38%的受训者来自任职人数不足的人 在科学人口中，%是女性，8%是内科科学家，45%接受了独立资助，而 在该计划的支持下，55%的受训人员在毕业时担任教职，受训人员平均为两名同龄人- 在该计划期间，每年审查出版物。在这里，我们提供了计划，以保持和丰富这种强大的 心血管研究培训计划，在资金充足的互动实验室进行博士后培训 来自生物化学系和心血管科的41位国际公认的领导者和心血管科学家 结构生物学、细胞系统与解剖学、牙髓内科学、机械工程、医学、神经学 神经外科、病理学、药理学、生理学、人口健康科学和外科学 位于圣安东尼奥的德克萨斯健康科学中心。简而言之，培训方案的主要组成部分包括： (1)有经验的研究人员以分级责任积极参与研究实验室；(2)a 致力于协作和使用多学科研究方法；(3)继续开展研究-- 进展研讨会，以及在国家/国际会议上和印刷本上传播调查结果；(4)综合 关于心血管科学主题的期刊俱乐部系列；(5)负责的教学课程和研讨会 研究的开展、科学的严谨性和重复性、科学交流和恩惠精神/同行 评审；(6)具有严格导师计划的团体辅导环境；(7)个人准备 发展计划和对受训人员进展情况的全面例行评价；(8)提交 独立赠款；(9)发展科学网络和职业管理继续培训；(10) 继续评估和教授指导教师和受训人员的指导技能；以及(11)积极的 招聘优秀的实习生和教职员工，充分反映劳动力的多样性。计划研究和培训 重点关注八个重叠的调查主题：(1)心律失常、纤维化和心力衰竭；(2)冠状动脉 动脉疾病和动脉粥样硬化；(3)脑血管疾病和中风；(4)糖尿病、代谢和 肥胖；(5)肾血管和神经源性高血压；(6)神经心血管反射；(7)心肾 调节失调；以及(8)细菌性和病毒性心脏病。这些主题的整合对于 了解心血管疾病的发病机制。考虑到复杂性和死亡率， 心血管疾病，这一培训计划的目标是继续为科学家提供必要的 未来生物医学研究所需的能力和专业知识广度。

This A1 resubmission is for continuation of a multi-disciplinary postdoctoral research training program in cardiovascular sciences that annually supports six (MD, DDS, DVM, PhD) research fellows. The program has a rich and sustained record of success training young scientists and future leaders over the past 40 years. Of trainees in the past ten years, 95% (37/39) are currently in science/medicine; 38% are from an underrepresented population in science, 64% are women, 8% are physician scientists, 45% received independent funding while supported by the program, 55% assumed faculty postions upon graduation, and trainees average two peer- reviewed publications per year while in the program. Here we provide plans to sustain and enrich this robust cardiovascular research training program with postdoctoral training in the well-funded, interactive laboratories of 41 internationally recognized leaders and cardiovascular scientists from the Departments of Biochemistry & Structural Biology, Cell Systems & Anatomy, Endodontics, Mechanical Engineering, Medicine, Neurology, Neurosurgery, Pathology, Pharmacology, Physiology, Population Health Sciences, and Surgery at the University of Texas Health Science Center at San Antonio. In brief, principal components of the training program include: (1) active participation with graded responsibility in the research laboratory of experienced investigators; (2) a commitment to collaboration and the use of multidisciplinary research approaches; (3) continuing research-in- progress seminars, and dissemination of findings at national/international meetings and in print; (4) integrated journal club series on topics in cardiovascular science; (5) didactic courses and seminars in the responsible conduct of research, scientific rigor and reproducibility, scientific communication, and grantsmanship/peer review; (6) a group mentoring environment with rigorous mentorship plans; (7) preparation of an individual development plan (IDP) and the comprehensive, routine evaluation of trainee progress; (8) submission of an independent grant; (9) development of scientific networks and continuing training in career stewardship; (10) the continued evaluation and teaching of mentoring skills to faculty preceptors and trainees; and (11) the active recruitment of meritorious trainees and faculty that well reflect workforce diversity. Program research and training focus on eight overlapping investigative themes: (1) Cardiac Arrhythmias, Fibrosis and Failure; (2) Coronary Artery Disease and Atherosclerosis; (3) Cerebrovascular Disease and Stroke; (4) Diabetes, Metabolism and Obesity; (5) Renovascular and Neurogenic Hypertension; (6) Neural Cardiovascular Reflexes; (7) Cardiorenal Dysregulation; and (8) Bacterial and Viral Heart Disease. Integration of these themes is essential to understanding the mechanisms of cardiovascular disease. Given the complexities, and mortality associated with cardiovascular disease, the goal of this training program is to continue to provide scientists with the necessary competencies and breadth of expertise required for future biomedical research.