Pathobiology of Occlusive Vascular Disease

这A1重新提交是一个多学科的博士后研究培训计划的延续， 心血管科学，每年支持六个（MD，DDS，DVM，博士）研究员。该程序有一个 过去40年来，在培养青年科学家和未来领导人方面取得了丰富和持续的成功记录。的 在过去十年中，95%（37/39）的受训人员目前在科学/医学领域; 38%来自代表性不足的国家。 在科学领域，64%是女性，8%是医生科学家，45%获得独立资助， 在该计划的支持下，55%的人在毕业后担任教职，学员平均两个同行， 每年出版物审查，而在该计划。在这里，我们提供计划，以维持和丰富这一强大的 心血管研究培训计划，在资金充足的互动实验室进行博士后培训， 41位来自生物化学和生物医学系的国际公认的领导者和心血管科学家 结构生物学，细胞系统与解剖学，牙髓病学，机械工程，医学，神经病学， 大学的神经外科、病理学、药理学、生理学、人口健康科学和外科 位于圣安东尼奥的德克萨斯健康科学中心。简而言之，培训方案的主要组成部分包括： (1)有经验的研究人员积极参与研究实验室的分级责任;（2）a 致力于合作和多学科研究方法的使用;（3）继续研究， 进展研讨会，并在国家/国际会议和印刷品上传播研究结果;（4） 心血管科学主题的期刊俱乐部系列;（5）负责的教学课程和研讨会 研究的进行、科学的严谨性和可重复性、科学交流和科学家/同行 审查;（6）具有严格指导计划的小组指导环境;（7）个人准备 发展计划（IDP）和对受训者进展的全面、常规评估;（8）提交 （9）发展科学网络和职业管理方面的继续培训;（10） 继续评估和教授指导教师和学员的技能;以及（11）积极的 招聘优秀的学员和教师，充分反映劳动力的多样性。方案研究和培训 重点关注八个重叠的研究主题：（1）心律失常、纤维化和衰竭;（2）冠状动脉 动脉疾病和动脉粥样硬化;（3）脑血管疾病和中风;（4）糖尿病、代谢和 肥胖;（5）肾血管性和神经源性高血压;（6）神经心血管反射;（7）肾性高血压 失调;和（8）细菌和病毒性心脏病。整合这些主题对于 了解心血管疾病的机制。考虑到这种疾病的复杂性和死亡率， 心血管疾病，这项培训计划的目标是继续为科学家提供必要的 未来生物医学研究所需的能力和专业知识的广度。

This A1 resubmission is for continuation of a multi-disciplinary postdoctoral research training program in cardiovascular sciences that annually supports six (MD, DDS, DVM, PhD) research fellows. The program has a rich and sustained record of success training young scientists and future leaders over the past 40 years. Of trainees in the past ten years, 95% (37/39) are currently in science/medicine; 38% are from an underrepresented population in science, 64% are women, 8% are physician scientists, 45% received independent funding while supported by the program, 55% assumed faculty postions upon graduation, and trainees average two peer- reviewed publications per year while in the program. Here we provide plans to sustain and enrich this robust cardiovascular research training program with postdoctoral training in the well-funded, interactive laboratories of 41 internationally recognized leaders and cardiovascular scientists from the Departments of Biochemistry & Structural Biology, Cell Systems & Anatomy, Endodontics, Mechanical Engineering, Medicine, Neurology, Neurosurgery, Pathology, Pharmacology, Physiology, Population Health Sciences, and Surgery at the University of Texas Health Science Center at San Antonio. In brief, principal components of the training program include: (1) active participation with graded responsibility in the research laboratory of experienced investigators; (2) a commitment to collaboration and the use of multidisciplinary research approaches; (3) continuing research-in- progress seminars, and dissemination of findings at national/international meetings and in print; (4) integrated journal club series on topics in cardiovascular science; (5) didactic courses and seminars in the responsible conduct of research, scientific rigor and reproducibility, scientific communication, and grantsmanship/peer review; (6) a group mentoring environment with rigorous mentorship plans; (7) preparation of an individual development plan (IDP) and the comprehensive, routine evaluation of trainee progress; (8) submission of an independent grant; (9) development of scientific networks and continuing training in career stewardship; (10) the continued evaluation and teaching of mentoring skills to faculty preceptors and trainees; and (11) the active recruitment of meritorious trainees and faculty that well reflect workforce diversity. Program research and training focus on eight overlapping investigative themes: (1) Cardiac Arrhythmias, Fibrosis and Failure; (2) Coronary Artery Disease and Atherosclerosis; (3) Cerebrovascular Disease and Stroke; (4) Diabetes, Metabolism and Obesity; (5) Renovascular and Neurogenic Hypertension; (6) Neural Cardiovascular Reflexes; (7) Cardiorenal Dysregulation; and (8) Bacterial and Viral Heart Disease. Integration of these themes is essential to understanding the mechanisms of cardiovascular disease. Given the complexities, and mortality associated with cardiovascular disease, the goal of this training program is to continue to provide scientists with the necessary competencies and breadth of expertise required for future biomedical research.