Pathobiology of Occlusive Vascular Disease

闭塞性血管疾病的病理学

• 批准号: 10680569
• 负责人: Jean Chrisostome Bopassa
• 金额: $ 29.36万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-07-01 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10680569
• 关键词: Vascular Diseases

This A1 resubmission is for continuation of a multi-disciplinary postdoctoral research training program in cardiovascular sciences that annually supports six (MD, DDS, DVM, PhD) research fellows. The program has a rich and sustained record of success training young scientists and future leaders over the past 40 years. Of trainees in the past ten years, 95% (37/39) are currently in science/medicine; 38% are from an underrepresented population in science, 64% are women, 8% are physician scientists, 45% received independent funding while supported by the program, 55% assumed faculty postions upon graduation, and trainees average two peer- reviewed publications per year while in the program. Here we provide plans to sustain and enrich this robust cardiovascular research training program with postdoctoral training in the well-funded, interactive laboratories of 41 internationally recognized leaders and cardiovascular scientists from the Departments of Biochemistry & Structural Biology, Cell Systems & Anatomy, Endodontics, Mechanical Engineering, Medicine, Neurology, Neurosurgery, Pathology, Pharmacology, Physiology, Population Health Sciences, and Surgery at the University of Texas Health Science Center at San Antonio. In brief, principal components of the training program include: (1) active participation with graded responsibility in the research laboratory of experienced investigators; (2) a commitment to collaboration and the use of multidisciplinary research approaches; (3) continuing research-in- progress seminars, and dissemination of findings at national/international meetings and in print; (4) integrated journal club series on topics in cardiovascular science; (5) didactic courses and seminars in the responsible conduct of research, scientific rigor and reproducibility, scientific communication, and grantsmanship/peer review; (6) a group mentoring environment with rigorous mentorship plans; (7) preparation of an individual development plan (IDP) and the comprehensive, routine evaluation of trainee progress; (8) submission of an independent grant; (9) development of scientific networks and continuing training in career stewardship; (10) the continued evaluation and teaching of mentoring skills to faculty preceptors and trainees; and (11) the active recruitment of meritorious trainees and faculty that well reflect workforce diversity. Program research and training focus on eight overlapping investigative themes: (1) Cardiac Arrhythmias, Fibrosis and Failure; (2) Coronary Artery Disease and Atherosclerosis; (3) Cerebrovascular Disease and Stroke; (4) Diabetes, Metabolism and Obesity; (5) Renovascular and Neurogenic Hypertension; (6) Neural Cardiovascular Reflexes; (7) Cardiorenal Dysregulation; and (8) Bacterial and Viral Heart Disease. Integration of these themes is essential to understanding the mechanisms of cardiovascular disease. Given the complexities, and mortality associated with cardiovascular disease, the goal of this training program is to continue to provide scientists with the necessary competencies and breadth of expertise required for future biomedical research.

本次A1再提交是为了继续一个多学科博士后研究培训计划

项目成果

Layer-Specific Manganese-Enhanced MRI of the Diabetic Rat Retina in Light and Dark Adaptation at 11.7 Tesla.

• DOI: 10.1167/iovs.14-16128
• 发表时间: 2015-06
• 期刊: Investigative ophthalmology & visual science
• 影响因子: 4.4
• 作者: E. Muir;S. Chandra;Bryan H. De La Garza;Chakradhar Velagapudi;H. Abboud;T. Duong

3D magnetic resonance microscopy of the ex vivo retina.

• DOI: 10.1002/mrm.23082
• 发表时间: 2012-04
• 期刊: MAGNETIC RESONANCE IN MEDICINE
• 影响因子: 3.3
• 作者: De La Garza, Bryan H.;Muir, Eric R.;Shih, Yen-Yu I.;Duong, Timothy Q.
• 通讯作者: Duong, Timothy Q.

Layer-specific functional and anatomical MRI of the retina with passband balanced SSFP.

带有平衡SSFP的视网膜的层特异性功能和解剖学MRI。

• DOI: 10.1002/mrm.22935
• 发表时间: 2011-11
• 期刊: MAGNETIC RESONANCE IN MEDICINE
• 影响因子: 3.3
• 作者: Muir, Eric R.;Duong, Timothy Q.
• 通讯作者: Duong, Timothy Q.

SCN2A contributes to oligodendroglia excitability and development in the mammalian brain.

• DOI: 10.1016/j.celrep.2021.109653
• 发表时间: 2021-09-07
• 期刊: Cell reports
• 影响因子: 8.8
• 作者: Gould E;Kim JH
• 通讯作者: Kim JH

Transgenic overexpression of matrix metalloproteinase-9 in macrophages attenuates the inflammatory response and improves left ventricular function post-myocardial infarction.

• DOI: 10.1016/j.yjmcc.2012.07.017
• 发表时间: 2012-11
• 期刊: Journal of molecular and cellular cardiology
• 影响因子: 5
• 作者: Zamilpa R;Ibarra J;de Castro Brás LE;Ramirez TA;Nguyen N;Halade GV;Zhang J;Dai Q;Dayah T;Chiao YA;Lowell W;Ahuja SS;D'Armiento J;Jin YF;Lindsey ML
• 通讯作者: Lindsey ML