Cardiovascular tissue engineering of scaffolds for the treatment of vascular diseases

心血管组织工程支架治疗血管疾病

• 批准号: 2796127
• 金额: --
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2796127
• 关键词: Cardiovascular; tissue; engineering; scaffolds; treatment

Cardiovascular diseases (CVDs) cover a broad spectrum of conditionswhose effects range from milddiscomfort and reduced quality of life to conditions which can be fatal if left untreated. Whilstcurrent medicinal methods can generally alleviate some of the symptoms of CVDs, sufferers of thesediseases are often left with a compromised cardiovascular network which requires carefulmanagement so as not t o re trigger the condition. Ideally, these vascular systems could be replacedwith fresh, autologous tissue, effectively treating the condition, and giving the patient a new leaseof life.A biological scaffold serves as a biomimetic physical platform fromwhich native cells may be seededand proliferate upon. When using an appropriate methodology, these cells may develop into fullyfunctional tissue. The initial material from which the scaffold is constructed is crucial, as ultimatelythe viability of the engineered tissue described by its structural and functional integrity, mechanicalproperties, and chance of rejection by the host is dictated to a large extent by this choice alone.One current area of interest is the use of a biodegradable polymer scaffold, through which themechanical properties of the scaffold may be controlled during cell proliferation, and, aftermaturation of the tissue, the scaffold will degrade and be naturally disposed of by the body. Furtherexploration into the development of polymer based biological scaffolds for use in cardiovascularsystems could yield significant improvements to prognoses of those who suffer from vasculardiseases.

心血管疾病（cvd）涵盖范围广泛，其影响范围从轻微不适和生活质量下降到如果不及时治疗可能致命的疾病。虽然目前的医学方法通常可以缓解心血管疾病的一些症状，但这些疾病的患者往往会留下一个受损的心血管网络，需要仔细管理，以免再次引发疾病。理想情况下，这些血管系统可以用新鲜的自体组织代替，有效地治疗这种疾病，并给病人带来新的生命。生物支架作为一种仿生物理平台，天然细胞可以在其上播种和增殖。当使用适当的方法时，这些细胞可以发育成功能齐全的组织。构建支架的初始材料是至关重要的，因为最终工程组织的生存能力由其结构和功能完整性、机械特性和宿主排斥的可能性在很大程度上取决于这种选择。目前研究的一个领域是使用可生物降解的聚合物支架，通过这种支架，支架的机械性能可以在细胞增殖过程中得到控制，并且在组织成熟后，支架将降解并被身体自然处理。进一步开发用于心血管系统的聚合物生物支架可以显著改善血管疾病患者的预后。