Duke/UNC Alzheimer's Disease Research Center

杜克大学/北卡罗来纳大学阿尔茨海默病研究中心

• 批准号: 10475313
• 负责人: GWENN A GARDEN
• 金额: $ 301.56万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10475313
• 关键词: Advocacy; Affect; Age; Age-associated memory impairment; Aging; Alzheimer' s Disease; Alzheimer' s disease pathology; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Award; Back; Bioinformatics; Biological; Biological Aging; Biological Markers; Biological Models; Biology of Aging; Biomedical Research; Brain; Caliber; Cardiovascular Diseases; Caregivers; Catchment Area; Clinical; Collaborations; Collection; Communication; Communities; Community Outreach; Complex; Coupled; Data; Data Analyses; Data Management Resources; Data Set; Data Store; Dementia; Development; Disease; Doctor of Philosophy; Down Syndrome; Education; Elderly; Elements; Enrollment; Environment; Event; Faculty; Family Caregiver; Fostering; Funding; Future; Gardenal; Generations; Geroscience; Goals; Health; Health Services; Heritability; Image; Impairment; Individual; Inflammation; Information Dissemination; Infrastructure; Institution; Investments; Joints; K-Series Research Career Programs; Leadership; Link; Liquid substance; Longevity; Longitudinal cohort; Mediating; Mentors; Metabolism; Minority-Serving Institution; Modeling; Neurologist; Neurology; North Carolina; Participant; Pathology; Pathway interactions; Patients; Persons; Phenotype; Pilot Projects; Positioning Attribute; Prevalence; Prevention; Process; Registries; Research; Research Activity; Research Personnel; Research Support; Resources; Role; Rural Community; Schools; Sensory; Services; Surveys; Symptoms; Syndrome; Testing; Tissue Banks; Training; Training Programs; Translations; United States National Institutes of Health; Universities; Update; Vision; Work; age related; biobank; care systems; clinical biomarkers; clinical center; cohort; comorbidity; data curation; data management; data resource; data sharing; design; disease phenotype; education research; experience; human data; imaging facilities; improved; innovation; investigator training; meetings; middle age; minority communities; neuropathology; novel; outreach; pre-clinical; programs; proteostasis; recruit; rural disparities; service engagement; statistics; translational pipeline; volunteer

ABSTRACT - OVERALL Before it kills, Alzheimer’s disease (AD) exacts a devastating toll on patients, families, caregivers, and communities. Moreover, even in 2020, there is still no prevention or cure for AD. To meet this challenge, the new Duke/University of North Carolina ADRC is poised to transform AD-related research and services across the Research Triangle and Eastern North Carolina. The new Duke/University of North Carolina Alzheimer’s Disease Research Center (Duke/UNC ADRC)’s theme is identifying age-related changes across the lifespan that mediate development, progression, and experience of Alzheimer’s disease (AD). In support of this theme, the Duke/UNC ADRC clinical cohort design and biomarker collection equips investigators with data and resources to discover new opportunities to intervene in the years before AD symptoms manifest. A related Center goal is to identify how factors that arise in early and mid-life contribute to racial and urban/rural disparities in dementia. The Center plans to provide infrastructure and resources aligned with the following specific aims: 1) Stimulate and support research on AD and Alzheimer’s disease-related dementias (AD+ADRD) for investigators from many fields by providing access to well-characterized subjects, curated data and biospecimens from diverse individuals across a wide age-spectrum with and without dementia, with emphasis on pre-clinical and early disease; 2) Attract and prepare diverse, creative, well-trained investigators to conduct high caliber research on AD+ADRD and 3) Improve lives impacted by age-related cognitive decline and increase the inclusiveness of this research. The Center’s Cores (Clinical, Biomarker, Neuropathology, Data Management and Statistics (DMS), Outreach, Recruitment, and Engagement (ORE), Administrative) and Research Education Component (REC) work collectively to pursue these aims, aided by our team’s decades of dementia outreach across North Carolina, strong existing ties to minority and rural communities, and institutional resources and experts in disparities research. The Center’s Clinical, Biomarker, and Neuropathology Cores, in conjunction with the ORE Core will support collection of images, biospecimens, and fluids from over 500 well-characterized participants across a broad age range. The DMS Core will support data curation and analysis by providing integrated data management and statistical/bioinformatics collaborative expertise. The REC will develop a robust and diverse pipeline of future leaders in AD+ADRD research through an innovative combination of widely disseminated curricular elements and more personalized mentoring experiences. The REC’s educational platforms extend to three additional Universities in our catchment area, including two majority minority institutions. The ADRC’s Cores and the REC, supported by the Administrative Core, will work in a coordinated manner to generate and store data and resources from people with and without dementia or AD risk, share data and expertise as widely as possible, and ultimately contribute back to the AD community through dissemination of results, education, and health services.

摘要-总体