Duke/UNC Alzheimer's Disease Research Center

摘要--总体 在致死之前，阿尔茨海默病(AD)对患者、家庭、照顾者和 社区。而且，即使在2020年，阿尔茨海默病仍然没有防治或治愈的方法。为了迎接这一挑战， 新杜克大学/北卡罗来纳大学ADRC准备转变与AD相关的研究和服务 研究三角地带和北卡罗来纳州东部。北卡罗来纳大学的新杜克/阿尔茨海默氏症 疾病研究中心(杜克大学/北卡罗来纳大学ADRC)S的主题是确定整个生命周期中与年龄相关的变化 调节阿尔茨海默病(AD)的发生、发展和经历的物质。为支持这一主题， 杜克大学/北卡罗来纳大学ADRC临床队列设计和生物标记物收集为研究人员提供了数据和 在阿尔茨海默病症状显现之前的几年里，发现新的干预机会的资源。A相关 中心目标是确定早年和中年时期出现的因素对种族和城市/农村的影响 痴呆症的差异。该中心计划提供符合以下要求的基础设施和资源 具体目标：1)促进和支持关于阿尔茨海默病和阿尔茨海默病相关痴呆的研究 (AD+ADRD)为来自多个领域的调查人员提供对具有良好特征的主题、精选数据的访问 以及来自不同年龄段的患有和不患有痴呆症的人的生物制品， 重视临床前和早期疾病；2)吸引和培养多样化、创造性、训练有素的研究人员 开展AD+ADRD的高水平研究；3)改善受年龄相关性认知功能减退影响的生活 增加了本研究的包容性。该中心的核心(临床、生物标志物、神经病理学、 数据管理和统计(DMS)、外联、征聘和聘用(ORE)、行政)和 研究教育部分(REC)在我们团队数十年的帮助下，共同努力实现这些目标 北卡罗来纳州的痴呆症宣传活动，与少数族裔和农村社区的牢固现有联系，以及 机构资源和差异研究方面的专家。该中心的临床、生物标志物和 神经病理学核心与ORE核心一起，将支持图像、生物显微镜和 来自500多名年龄范围广泛的参与者的体液。DMS核心将支持数据 通过提供集成的数据管理和统计/生物信息学协作进行管理和分析 专业知识。REC将通过以下方式在AD+ADRD研究中发展一个强大而多样化的未来领导者渠道 广泛传播的课程元素和更个性化的指导的创新组合 经历。REC的教育平台延伸到我们集水区的另外三所大学， 包括两个占多数的少数族裔机构。ADRC的核心和REC，得到行政部门的支持 核心，将以协调的方式工作，以生成和存储来自具有和 没有痴呆症或AD风险，尽可能广泛地共享数据和专业知识，并最终为 通过传播成果、教育和卫生服务，促进AD社区的发展。

ABSTRACT - OVERALL Before it kills, Alzheimer’s disease (AD) exacts a devastating toll on patients, families, caregivers, and communities. Moreover, even in 2020, there is still no prevention or cure for AD. To meet this challenge, the new Duke/University of North Carolina ADRC is poised to transform AD-related research and services across the Research Triangle and Eastern North Carolina. The new Duke/University of North Carolina Alzheimer’s Disease Research Center (Duke/UNC ADRC)’s theme is identifying age-related changes across the lifespan that mediate development, progression, and experience of Alzheimer’s disease (AD). In support of this theme, the Duke/UNC ADRC clinical cohort design and biomarker collection equips investigators with data and resources to discover new opportunities to intervene in the years before AD symptoms manifest. A related Center goal is to identify how factors that arise in early and mid-life contribute to racial and urban/rural disparities in dementia. The Center plans to provide infrastructure and resources aligned with the following specific aims: 1) Stimulate and support research on AD and Alzheimer’s disease-related dementias (AD+ADRD) for investigators from many fields by providing access to well-characterized subjects, curated data and biospecimens from diverse individuals across a wide age-spectrum with and without dementia, with emphasis on pre-clinical and early disease; 2) Attract and prepare diverse, creative, well-trained investigators to conduct high caliber research on AD+ADRD and 3) Improve lives impacted by age-related cognitive decline and increase the inclusiveness of this research. The Center’s Cores (Clinical, Biomarker, Neuropathology, Data Management and Statistics (DMS), Outreach, Recruitment, and Engagement (ORE), Administrative) and Research Education Component (REC) work collectively to pursue these aims, aided by our team’s decades of dementia outreach across North Carolina, strong existing ties to minority and rural communities, and institutional resources and experts in disparities research. The Center’s Clinical, Biomarker, and Neuropathology Cores, in conjunction with the ORE Core will support collection of images, biospecimens, and fluids from over 500 well-characterized participants across a broad age range. The DMS Core will support data curation and analysis by providing integrated data management and statistical/bioinformatics collaborative expertise. The REC will develop a robust and diverse pipeline of future leaders in AD+ADRD research through an innovative combination of widely disseminated curricular elements and more personalized mentoring experiences. The REC’s educational platforms extend to three additional Universities in our catchment area, including two majority minority institutions. The ADRC’s Cores and the REC, supported by the Administrative Core, will work in a coordinated manner to generate and store data and resources from people with and without dementia or AD risk, share data and expertise as widely as possible, and ultimately contribute back to the AD community through dissemination of results, education, and health services.