Duke/UNC Alzheimer's Disease Research Center

杜克大学/北卡罗来纳大学阿尔茨海默病研究中心

• 批准号: 10263683
• 负责人: GWENN A GARDEN
• 金额: $ 312.8万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10263683
• 关键词: Advocacy; Affect; Age; Age-associated memory impairment; Aging; Alzheimer' s Disease; Alzheimer' s disease pathology; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Award; Back; Bioinformatics; Biological; Biological Aging; Biological Markers; Biological Models; Biology of Aging; Biomedical Research; Brain; Caliber; Cardiovascular Diseases; Caregivers; Catchment Area; Clinical; Collaborations; Collection; Communication; Communities; Community Outreach; Complex; Coupled; Data; Data Analyses; Data Management Resources; Data Set; Data Store; Dementia; Development; Disease; Doctor of Philosophy; Down Syndrome; Education; Elderly; Elements; Enrollment; Environment; Event; Faculty; Family Caregiver; Fostering; Funding; Future; Gardenal; Generations; Geroscience; Goals; Health; Health Services; Heritability; Image; Impairment; Individual; Inflammation; Information Dissemination; Infrastructure; Institution; Investments; Joints; K-Series Research Career Programs; Leadership; Link; Liquid substance; Longevity; Longitudinal cohort; Mediating; Mentors; Metabolism; Minority-Serving Institution; Modeling; Neurologist; Neurology; North Carolina; Participant; Pathology; Pathway interactions; Patients; Phenotype; Pilot Projects; Positioning Attribute; Prevalence; Prevention; Process; Registries; Research; Research Activity; Research Personnel; Research Support; Resources; Role; Rural Community; Schools; Sensory; Services; Surveys; Symptoms; Syndrome; Testing; Tissue Banks; Training; Training Programs; Translations; United States National Institutes of Health; Universities; Update; Vision; Work; age related; biobank; care systems; clinical biomarkers; clinical center; cohort; comorbidity; data curation; data management; data resource; data sharing; design; disease phenotype; education research; experience; human data; improved; innovation; investigator training; meetings; middle age; minority communities; neuropathology; novel; outreach; pre-clinical; programs; proteostasis; recruit; rural disparities; service engagement; statistics; translational pipeline; volunteer

ABSTRACT - OVERALL Before it kills, Alzheimer’s disease (AD) exacts a devastating toll on patients, families, caregivers, and communities. Moreover, even in 2020, there is still no prevention or cure for AD. To meet this challenge, the new Duke/University of North Carolina ADRC is poised to transform AD-related research and services across the Research Triangle and Eastern North Carolina. The new Duke/University of North Carolina Alzheimer’s Disease Research Center (Duke/UNC ADRC)’s theme is identifying age-related changes across the lifespan that mediate development, progression, and experience of Alzheimer’s disease (AD). In support of this theme, the Duke/UNC ADRC clinical cohort design and biomarker collection equips investigators with data and resources to discover new opportunities to intervene in the years before AD symptoms manifest. A related Center goal is to identify how factors that arise in early and mid-life contribute to racial and urban/rural disparities in dementia. The Center plans to provide infrastructure and resources aligned with the following specific aims: 1) Stimulate and support research on AD and Alzheimer’s disease-related dementias (AD+ADRD) for investigators from many fields by providing access to well-characterized subjects, curated data and biospecimens from diverse individuals across a wide age-spectrum with and without dementia, with emphasis on pre-clinical and early disease; 2) Attract and prepare diverse, creative, well-trained investigators to conduct high caliber research on AD+ADRD and 3) Improve lives impacted by age-related cognitive decline and increase the inclusiveness of this research. The Center’s Cores (Clinical, Biomarker, Neuropathology, Data Management and Statistics (DMS), Outreach, Recruitment, and Engagement (ORE), Administrative) and Research Education Component (REC) work collectively to pursue these aims, aided by our team’s decades of dementia outreach across North Carolina, strong existing ties to minority and rural communities, and institutional resources and experts in disparities research. The Center’s Clinical, Biomarker, and Neuropathology Cores, in conjunction with the ORE Core will support collection of images, biospecimens, and fluids from over 500 well-characterized participants across a broad age range. The DMS Core will support data curation and analysis by providing integrated data management and statistical/bioinformatics collaborative expertise. The REC will develop a robust and diverse pipeline of future leaders in AD+ADRD research through an innovative combination of widely disseminated curricular elements and more personalized mentoring experiences. The REC’s educational platforms extend to three additional Universities in our catchment area, including two majority minority institutions. The ADRC’s Cores and the REC, supported by the Administrative Core, will work in a coordinated manner to generate and store data and resources from people with and without dementia or AD risk, share data and expertise as widely as possible, and ultimately contribute back to the AD community through dissemination of results, education, and health services.

摘要-总体 在它杀死之前，阿尔茨海默病（AD）对患者，家庭，护理人员和患者造成了毁灭性的损失。 社区.此外，即使到2020年，仍然没有预防或治愈AD。为了迎接这一挑战， 新的杜克/北卡罗来纳州大学ADRC准备改变广告相关的研究和服务， 三角研究区和东北卡罗来纳州。新的杜克/北卡罗来纳州大学阿尔茨海默氏症 疾病研究中心（杜克/ADRC）的主题是确定整个生命周期中与年龄相关的变化 其介导阿尔茨海默病（AD）的发展、进展和经历。为了支持这一主题， 杜克/杜克大学ADRC临床队列设计和生物标志物收集为研究者提供了数据， 资源，以发现新的机会，干预前几年的AD症状表现。一个相关 该中心的目标是确定早期和中期生活中出现的因素如何影响种族和城市/农村 痴呆症的差异。该中心计划提供与以下方面相一致的基础设施和资源 具体目标：1）促进和支持对AD和阿尔茨海默病相关痴呆症的研究 (AD+ADRD），为来自许多领域的研究人员提供访问良好表征的受试者，策划的数据 来自不同年龄段的不同个体的生物标本，包括痴呆和非痴呆， 强调临床前和早期疾病; 2）吸引和准备多样化，创造性，训练有素的研究人员 对AD+ADRD进行高水平的研究，3）改善受年龄相关认知下降影响的生活 增加这项研究的包容性。该中心的核心（临床，生物标志物，神经病理学， 数据管理和统计（DMS），外联，招聘和参与（ORE），行政）和 研究教育组成部分（REC）共同努力，以追求这些目标，我们的团队的几十年的帮助下， 北卡罗来纳州的痴呆症外展，与少数民族和农村社区的现有联系，以及 机构资源和差距研究专家。该中心的临床，生物标志物， 神经病理学核心与ORE核心一起将支持图像、生物标本和 来自500多名年龄范围广泛的特征良好的参与者的液体。DMS核心将支持数据 通过提供综合数据管理和统计/生物信息学协作， 专业知识REC将通过以下方式为AD+ADRD研究的未来领导者建立一个强大而多样化的管道： 广泛传播的课程元素和更个性化的指导的创新组合 经验REC的教育平台延伸到我们流域的另外三所大学， 包括两个占多数的少数民族机构。ADRC的核心和REC，由行政部门支持 核心，将以协调的方式工作，以生成和存储数据和资源， 在没有痴呆或AD风险的情况下，尽可能广泛地分享数据和专业知识，并最终为 通过传播成果、教育和卫生服务，帮助AD社区。