Biomarker Core

生物标志物核心

• 批准号: 10475321
• 负责人: ALLEN W SONG
• 金额: $ 48.79万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10475321
• 关键词: Affect; Algorithms; Alzheimer' s Disease; Alzheimer' s disease pathology; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Alzheimer’s disease biomarker; Amyloid; Area; Biological Markers; Blood; Brain; Brain imaging; Caliber; Cells; Clinical; Collaborations; Communities; Cortical Column; Data; Data Analyses; Databases; Dementia; Detection; Development; Disease; Disease Progression; Early Diagnosis; Enrollment; Environmental Risk Factor; Faculty; Family; Funding; Genetic Risk; Genomics; Goals; Human; Image; Image Analysis; Imaging Device; Individual; Investigation; Knowledge; Lead; Magnetic Resonance Imaging; Measures; Methodology; Modality; Monitor; Nerve Degeneration; Neurodegenerative Disorders; Organ; Participant; Patients; Persons; Positron-Emission Tomography; Prevention; Proteins; Proteomics; Provider; Research; Research Personnel; Research Project Grants; Resolution; Resources; Sensory; Signal Transduction; Standardization; Symptoms; Synapses; Time; Tracer; Training; Work; adjudicate; age related; biomarker development; cohort; data acquisition; data management; density; disease diagnosis; early detection biomarkers; education research; experience; high risk population; human old age (65+); human subject; imaging biomarker; improved; innovation; magnetic resonance imaging biomarker; metabolomics; next generation; novel; novel marker; outreach; pre-clinical; recruit; resilience; retinal imaging; standardize measure; statistics; tau Proteins; wearable device

ABSTRACT – BIOMARKER CORE The objective of the Biomarker Core is to acquire and analyze biofluid and imaging biomarkers, characterize their relevance to Alzheimer’s disease (AD), and determine the underlying age-related factors that drive the development, progression, or experience of the disease. To achieve these goals, we bring together experts across diverse backgrounds in genomics, proteomics, metabolomics, and imaging to provide institutional resources to serve ADRC investigators, help initiate new collaborations, and train the next generation of AD and Alzheimer’s disease-related dementia (AD+ADRD) biomarkers researchers. Specifically, we propose four aims: 1) Acquire conventional and novel biomarkers in biofluid (CSF, blood), brain images (PET, MRI), and sensory organ data (retinal imaging) in adjudicated participant groups. Working closely with the Clinical Core, we will acquire CSF, blood, PET and MRI biomarkers in our clinical cohort to submit to the National Alzheimer’s Coordinating Center (NACC). At the same time, we will collaborate closely with independently funded research projects to acquire novel and early biomarkers in high-risk populations during the prodromal or early symptomatic stages of AD pathology. 2) Analyze biomarkers to obtain standardized measures and support relevant funded research projects within the ADRC community. We will perform standardized analyses in biofluid and imaging data to extract conventional biomarkers, and collaborate with existing funded projects to develop specialized analytics to identify novel biomarkers that can lead to earlier detection and prevention. 3) Provide resources to ADRC researchers integrating standardized multi-dimensional biomarkers data across all participants to characterize the underlying age-related drivers for AD. Working closely with the Data Management and Statistics Core, we will create and curate a multi-dimensional database, integrating all acquired biomarkers and clinical measures. This database will be used to assist and train the next generation of AD researchers in their investigations of underlying age-related drivers of AD, through collaborations with the Research Education Component. 4) Disseminate our expertise and knowledge to support the AD community at large. Working with the Outreach, Recruitment, and Engagement Core, we will disseminate our expertise and knowledge on established and emerging biomarkers to the local AD stakeholder community, other ADRC centers, and AD+ADRD researchers and providers across the nation. Through these four aims, we hope to help achieve our overall objective to catalyze and support high- caliber research and innovations to reduce the burden of AD and its impact on patients and families.

摘要 – 生物标志物核心 生物标记核心的目标是获取和分析生物流体和成像生物标记，表征 它们与阿尔茨海默病 (AD) 的相关性，并确定驱动阿尔茨海默氏病 (AD) 的潜在年龄相关因素 疾病的发展、进展或经历。为了实现这些目标，我们汇集了专家 跨越基因组学、蛋白质组学、代谢组学和成像领域的不同背景，为机构提供 为 ADRC 研究人员提供服务、帮助启动新的合作以及培训下一代 ADRC 的资源 以及阿尔茨海默病相关痴呆 (AD+ADRD) 生物标志物研究人员。具体来说，我们建议 四个目标：1) 获取生物体液（脑脊液、血液）、脑图像（PET、MRI）中的传统和新型生物标志物， 以及裁定的参与者组中的感觉器官数据（视网膜成像）。与临床密切合作 核心，我们将在临床队列中获取脑脊液、血液、PET 和 MRI 生物标志物，并提交给国家 阿尔茨海默病协调中心 (NACC)。同时，我们将与独立的 资助研究项目，以在前驱期获取高危人群的新颖和早期生物标志物 或 AD 病理学的早期症状阶段。 2) 分析生物标志物以获得标准化测量结果 支持 ADRC 社区内相关资助的研究项目。我们将执行标准化 分析生物流体和成像数据以提取传统生物标志物，并与现有的合作 资助开发专门分析的项目，以识别可导致早期检测的新型生物标志物 和预防。 3）为ADRC研究人员提供整合标准化多维度的资源 所有参与者的生物标志物数据来描述 AD 的潜在年龄相关驱动因素。在职的 与数据管理和统计核心密切合作，我们将创建和策划一个多维的 数据库，整合所有获得的生物标志物和临床指标。该数据库将用于协助和 培训下一代 AD 研究人员调查与年龄相关的 AD 潜在驱动因素， 通过与研究教育部分的合作。 4）传播我们的专业知识和 知识来支持整个 AD 社区。与外展、招聘和参与合作 核心，我们将向当地传播我们关于已建立和新兴生物标志物的专业知识和知识 AD 利益相关者社区、其他 ADRC 中心以及 AD+ADRD 研究人员和提供商 国家。通过这四个目标，我们希望帮助实现我们的总体目标，以促进和支持高 高质量的研究和创新，以减轻 AD 的负担及其对患者和家庭的影响。