High Fidelity Diffusion MRI for Children with Cerebral Palsy in Stem Cell Therapy
High Fidelity Diffusion MRI for Children with Cerebral Palsy in Stem Cell Therapy
批准号:
10187662
负责人:
ALLEN W SONG
金额:
$35.22万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2012
资助国家:
美国
项目状态:
已结题
起止时间:
2012-02-15 至 2023-06-30
关键词:
3-DimensionalAffectAlgorithmsAllogenicAutologousBehavioralBirthBlood BanksBrainBrain DiseasesCell TherapyCellsCerebral PalsyChildChildhoodClinicalCognitiveCollaborationsComputer softwareDevelopmentDiffusion Magnetic Resonance ImagingDoseEnsureFoundationsHematopoietic stem cellsImageImmunityImpaired cognitionImpairmentIndividualInjuryInnovative TherapyInterventionInvestigationLive BirthMagnetic Resonance ImagingMagnetismMapsMeasuresMethodologyMorphologic artifactsMotionMotorMotor PathwaysMyelinNoiseNorth CarolinaPathologyPathway interactionsPatientsPerformancePredispositionPublic HealthRecovery of FunctionResearchResearch PersonnelResolutionRiskSeveritiesSignal TransductionSolidSystemTechnologyThe SunTimeUmbilical Cord BloodUmbilical Cord Blood Transplantationbasebrain repairchildhood motor disordersclinical practiceconnectomedisabilitydosageeffective therapyfunctional improvementfunctional outcomesimage guidedimprovedin uteroinnovationmagnetic fieldmotor disordermyelinationneuromechanismnext generationnoveloperationperinatal injuryprogramsradio frequencyreconstructionrepairedrestorationstem cell therapystem cellssuccesstoolwhite matter
中文摘要
文摘:
英文摘要
Abstract:
Cerebral palsy (CP) is the most prevalent motor disorder of childhood with complications in other cognitive
impairments, affecting 3 out of every 1,000 children. Largely due to in utero or perinatal injuries to the
developing brain, CP results in white matter pathology including impairments to the motor pathway.
Diffusion MRI (e.g. diffusion tensor imaging, or DTI) can help characterize these white matter impairments,
as well as any potential connectivity improvement during treatment. Over the past five years, we have applied
high-fidelity diffusion MRI in pediatric CP patients during autologous umbilical cord blood (UCB) stem cell
therapies, and developed an understanding of the impact and benefit autologous UCB stem cells have on
improving functional outcome and brain connectivity in pediatric CP patients. Specifically, we have found
strong evidences in relevant brain networks that: 1) brain connectivity impairments account for the motor
and cognitive abnormalities in children with CP at the pre-treatment baseline, 2) brain connectivity increases
have a direct impact on functional and behavioral improvements during UCB stem cell therapy, 3) brain
connectivity increases beyond that of typical development trajectory have a direct correlation with stem cell
dosage above a potential threshold of 1.98 x 107 cells/kg, and 4) the severity of baseline connectivity
abnormalities predicts the risk of further decline and the benefit of cell therapy. It was also found that the
brain connectivity increase may be associated with improved myelination during cell therapy, through
additional preliminary investigations using quantitative susceptibility mapping (QSM). Advancing from this
solid foundation, we propose this renewal application to further develop ultrahigh resolution diffusion MRI
and connectivity imaging methodologies to study the positive effect of allogenic stem cells derived from UCB
(stored at the North Carolina Cord Blood Bank), which can both reach the necessary high dosage (as opposed
to the limited autologous UCB stem cells) and be applied to more CP patients (rather than just the ones with
UCB saved at birth). Specifically, we propose to: 1) achieve unprecedented magnetic field homogeneity based
on our recent innovation on simultaneous RF reception and Bo shimming technology to enable the highest
possible spatial resolution and fidelity, 2) achieve multi-band multi-shot 3D diffusion MRI acquisition with
ultrahigh submillimeter spatial resolution, optimized SNR and high throughput, and 3) acquire and analyze
ultrahigh resolution diffusion MRI and brain connectome maps, as well as DTI-guided myelin-sensitive QSM
along white matter pathways and throughout the brain connectome, in pediatric CP patients during the
course of innovative therapies using UCB-derived allogenic stem cells. It is expected that our continued and
concerted efforts will greatly advance our understanding of the neural mechanisms on both connectivity
impairments in children with CP at the baseline and on the impact of stem cell therapy on connectivity
restorations, ultimately providing compelling evidence to help plan the best treatment options.
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DOI:
10.1016/j.neuroimage.2023.119993
发表时间:
2023-04-15
期刊:
NEUROIMAGE
影响因子:
5.7
作者:
[Ma, Yixin, Bruce, Iain P., Yeh, Chun-Hung, Petrella, Jeffrey R., Song, Allen W., Truong, Trong-Kha]
通讯作者:
Truong, Trong-Kha
DOI:
10.1002/sctm.17-0102
发表时间:
2017-12
期刊:
Stem cells translational medicine
影响因子:
6
作者:
[Sun JM, Song AW, Case LE, Mikati MA, Gustafson KE, Simmons R, Goldstein R, Petry J, McLaughlin C, Waters-Pick B, Chen LW, Wease S, Blackwell B, Worley G, Troy J, Kurtzberg J]
通讯作者:
Kurtzberg J
DOI:
10.1002/jmri.27865
发表时间:
2022-04
期刊:
JOURNAL OF MAGNETIC RESONANCE IMAGING
影响因子:
4.4
作者:
[Darnell, Dean, Truong, Trong-Kha, Song, Allen W.]
通讯作者:
Song, Allen W.
Simultaneous and inherent correction of B0 and eddy-current induced distortions in high-resolution diffusion MRI using reversed polarity gradients and multiplexed sensitivity encoding (RPG-MUSE).
使用反向极性梯度和多路复用灵敏度编码 (RPG-MUSE) 对高分辨率扩散 MRI 中的 B0 和涡流引起的畸变进行同步和固有校正。
DOI:
10.1016/j.neuroimage.2018.09.055
发表时间:
2018
期刊:
NeuroImage
影响因子:
5.7
作者:
[Bruce,IainP, Petty,Christopher, Song,AllenW]
通讯作者:
Song,AllenW
A High-Performance 3T MRI Scanner for Brain Imaging
-
批准号:10175380
-
项目类别:
-
资助金额:$180.0万
-
财政年份:2021
-
负责人:ALLEN W SONG
-
依托单位:
Biomarker Core
-
批准号:10475321
-
项目类别:
-
资助金额:$48.79万
-
财政年份:2021
-
负责人:ALLEN W SONG
-
依托单位:
Biomarker Core
-
批准号:10263689
-
项目类别:
-
资助金额:$57.91万
-
财政年份:2021
-
负责人:ALLEN W SONG
-
依托单位:
Biomarker Core
-
批准号:10663999
-
项目类别:
-
资助金额:$43.43万
-
财政年份:2021
-
负责人:ALLEN W SONG
-
依托单位:
A Compute Cluster for Brain Imaging and Analysis
-
批准号:9072820
-
项目类别:
-
资助金额:$56.82万
-
财政年份:2016
-
负责人:ALLEN W SONG
-
依托单位:
Magnetic resonance imaging with inherent local shimming
-
批准号:8878559
-
项目类别:
-
资助金额:$23.78万
-
财政年份:2015
-
负责人:ALLEN W SONG
-
依托单位:
Path Toward MRI with Direct Sensitivity to Neuro-Electro-Magnetic Oscillations
-
批准号:8826908
-
项目类别:
-
资助金额:$47.1万
-
财政年份:2014
-
负责人:ALLEN W SONG
-
依托单位:
Path Toward MRI with Direct Sensitivity to Neuro-Electro-Magnetic Oscillations
-
批准号:9085395
-
项目类别:
-
资助金额:$46.76万
-
财政年份:2014
-
负责人:ALLEN W SONG
-
依托单位:
Path Toward MRI with Direct Sensitivity to Neuro-Electro-Magnetic Oscillations
-
批准号:8935948
-
项目类别:
-
资助金额:$47.29万
-
财政年份:2014
-
负责人:ALLEN W SONG
-
依托单位:
High Fidelity Diffusion MRI for Children with Cerebral Palsy in Stem Cell Therapy
-
批准号:8289889
-
项目类别:
-
资助金额:$34.13万
-
财政年份:2012
-
负责人:ALLEN W SONG
-
依托单位:
High Fidelity Diffusion MRI for Children with Cerebral Palsy in Stem Cell Therapy
-
批准号:8790476
-
项目类别:
-
资助金额:$34.12万
-
财政年份:2012
-
负责人:ALLEN W SONG
-
依托单位:
High Fidelity Diffusion MRI for Children with Cerebral Palsy in Stem Cell Therapy
-
批准号:8420412
-
项目类别:
-
资助金额:$32.93万
-
财政年份:2012
-
负责人:ALLEN W SONG
-
依托单位:
High Fidelity Diffusion MRI for Children with Cerebral Palsy in Stem Cell Therapy
-
批准号:8606268
-
项目类别:
-
资助金额:$33.78万
-
财政年份:2012
-
负责人:ALLEN W SONG
-
依托单位:
Magnetic Resonance Imaging of Cortical Neuronal Activity
-
批准号:8448584
-
项目类别:
-
资助金额:$28.39万
-
财政年份:2010
-
负责人:ALLEN W SONG
-
依托单位:
Magnetic Resonance Imaging of Cortical Neuronal Activity
-
批准号:8233512
-
项目类别:
-
资助金额:$30.12万
-
财政年份:2010
-
负责人:ALLEN W SONG
-
依托单位:
Magnetic Resonance Imaging of Cortical Neuronal Activity
-
批准号:7985378
-
项目类别:
-
资助金额:$31.37万
-
财政年份:2010
-
负责人:ALLEN W SONG
-
依托单位:
Magnetic Resonance Imaging of Cortical Neuronal Activity
-
批准号:8092749
-
项目类别:
-
资助金额:$30.14万
-
财政年份:2010
-
负责人:ALLEN W SONG
-
依托单位:
Myelin-Specific Diffusion Tensor Imaging for Developmental Neuroimaging
-
批准号:7845711
-
项目类别:
-
资助金额:$23.17万
-
财政年份:2009
-
负责人:ALLEN W SONG
-
依托单位:
A Linux Cluster Computational Facility for Neuroimaging Research
-
批准号:7595617
-
项目类别:
-
资助金额:$26.7万
-
财政年份:2009
-
负责人:ALLEN W SONG
-
依托单位:
Imaging physics development
-
批准号:7156151
-
项目类别:
-
资助金额:$17.33万
-
财政年份:2006
-
负责人:ALLEN W SONG
-
依托单位:
海外基金