Path Toward MRI with Direct Sensitivity to Neuro-Electro-Magnetic Oscillations

对神经电磁振荡具有直接敏感性的 MRI 之路

基本信息

  • 批准号:
    8826908
  • 负责人:
  • 金额:
    $ 47.1万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2014
  • 资助国家:
    美国
  • 起止时间:
    2014-09-26 至 2017-06-30
  • 项目状态:
    已结题

项目摘要

 DESCRIPTION (provided by applicant): In response to the NIH RFA-MH-14-217 on "Planning for Next Generation Human Brain Imaging", we propose a comprehensive plan to organize the much needed technological resources and interdisciplinary research team for developing the next generation MRI technology that can directly detect neuroelectric activities in the human brain with a high spatial and temporal resolution, using scanners with the 3 Tesla magnetic field strength that is accessible by the majority of neuroimaging researchers. Through our encouraging preliminary investigations, we have determined that it is possible to precisely map brain activities by directly sensitizing the MRI signal to the neuro-electro-magnetic oscillations (NEMO). At the same time, we have also identified key challenges in MRI hardware, acquisition methods, and contrast mechanisms to fully enable this approach. We will address these challenges by organizing three innovative technical cores (in the form of Technical Aims) for the purpose of enabling an ultra-uniform magnetic field throughout the brain to ensure a robust detection of the NEMO signal, reaching ultra-high spatial resolutions that can resolve fine-grained cortical microstructures, and building a non-invasive human brain-machine interface (BMI) that models and classifies the functional neuroimaging signals and drives an attached robotic exoskeleton. To establish convincing evidences toward a direct and sensitive MRI detection of neuroelectric activity, and based on our solid technical foundation, we also propose four innovative pilot projects (in the form of Scientific Aims) to construct a static neural networ with causal information using high-resolution MRI, to investigate dynamic NEMO signals in vivo with enhanced sensitivity during both driven and intrinsic neuronal oscillations, and to model and classify the dynamic neuroimaging signals and to replicate and validate the human behavior in the robotic exoskeleton through our non-invasive human BMI. To help evaluate our research progress and receive critical input from researchers and leaders in the brain research community, we will organize annual workshops coordinated by our interdisciplinary research team and our scientific advisory committee. We anticipate that through these comprehensive planning and research activities, we will be able to define a clear path to reach the next generation human brain imaging technology that can precisely, non-invasively, and unambiguously map brain activities with unprecedented spatial and temporal resolution.


项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(1)

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ALLEN W SONG其他文献

ALLEN W SONG的其他文献

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{{ truncateString('ALLEN W SONG', 18)}}的其他基金

A High-Performance 3T MRI Scanner for Brain Imaging
用于脑成像的高性能 3T MRI 扫描仪
  • 批准号:
    10175380
  • 财政年份:
    2021
  • 资助金额:
    $ 47.1万
  • 项目类别:
Biomarker Core
生物标志物核心
  • 批准号:
    10475321
  • 财政年份:
    2021
  • 资助金额:
    $ 47.1万
  • 项目类别:
Biomarker Core
生物标志物核心
  • 批准号:
    10263689
  • 财政年份:
    2021
  • 资助金额:
    $ 47.1万
  • 项目类别:
Biomarker Core
生物标志物核心
  • 批准号:
    10663999
  • 财政年份:
    2021
  • 资助金额:
    $ 47.1万
  • 项目类别:
A Compute Cluster for Brain Imaging and Analysis
用于脑成像和分析的计算集群
  • 批准号:
    9072820
  • 财政年份:
    2016
  • 资助金额:
    $ 47.1万
  • 项目类别:
Magnetic resonance imaging with inherent local shimming
具有固有局部匀场的磁共振成像
  • 批准号:
    8878559
  • 财政年份:
    2015
  • 资助金额:
    $ 47.1万
  • 项目类别:
Path Toward MRI with Direct Sensitivity to Neuro-Electro-Magnetic Oscillations
对神经电磁振荡具有直接敏感性的 MRI 之路
  • 批准号:
    9085395
  • 财政年份:
    2014
  • 资助金额:
    $ 47.1万
  • 项目类别:
Path Toward MRI with Direct Sensitivity to Neuro-Electro-Magnetic Oscillations
对神经电磁振荡具有直接敏感性的 MRI 之路
  • 批准号:
    8935948
  • 财政年份:
    2014
  • 资助金额:
    $ 47.1万
  • 项目类别:
High Fidelity Diffusion MRI for Children with Cerebral Palsy in Stem Cell Therapy
干细胞治疗中脑瘫儿童的高保真扩散 MRI
  • 批准号:
    8289889
  • 财政年份:
    2012
  • 资助金额:
    $ 47.1万
  • 项目类别:
High Fidelity Diffusion MRI for Children with Cerebral Palsy in Stem Cell Therapy
干细胞治疗中脑瘫儿童的高保真扩散 MRI
  • 批准号:
    10187662
  • 财政年份:
    2012
  • 资助金额:
    $ 47.1万
  • 项目类别:

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  • 批准号:
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