Chronic Hookah (Waterpipe) Smoking, Vascular Dysfunction, Inflammation and Oxidative Stress
慢性吸水烟、血管功能障碍、炎症和氧化应激
基本信息
- 批准号:10475100
- 负责人:
- 金额:$ 46.55万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-15 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:AcuteAdultAdvertisementsAffectAgeAge-YearsAir PollutantsAntioxidantsAtherosclerosisAttentionAttenuatedBackBeliefBiological AssayBiological MarkersBlood CirculationBlood VesselsC-reactive proteinCarbon MonoxideCardiovascular DiseasesCardiovascular systemCharcoalChronicCigaretteCigarette SmokerDataDilatorEndotheliumEpidemicExposure toFibrinogenFillerFlavoringFoundationsFree RadicalsFruitFutureGasesGoalsHealthHigh Density LipoproteinsImpairmentInflammationLong-Term EffectsLongitudinal StudiesMarketingMasksMeasuresMediatingMethodologyMythologyNicotineOxidantsOxidative StressOxygenPathologic ProcessesPeripheralPhysiologic pulsePhysiologicalPlasmaPoliciesProstaglandinsRegulationResearchRiskSmokeSmokerSmokingTestingTobaccoTobacco smoking behaviorTobacco useVascular DiseasesVasodilationVasodilator AgentsVasomotorWaterYoutharterial stiffnessbasebrachial arterycardiovascular effectscigarette smokingcombustion productcomparativeendothelial dysfunctionevidence baseexperimental studyfine particleshookahindexinginflammatory markermennon-cigarette tobacco productnon-smokerparticlepressureresponsesexsmoking exposuretobacco exposuretobacco flavortobacco productsultrafine particlevascular inflammationyoung adult
项目摘要
Project Summary
Tobacco smoking using a hookah (waterpipe) is rapidly increasing in popularity worldwide, particularly among
youth. The spread of hookah smoking is promoted by the unsubstantiated belief that smoke is detoxified as it
passes through the water filled basin; heavy marketing and glamorization of fruit-flavored tobacco products; and
lack of policy regulation. Because traditional hookah is the only form of tobacco product that uses burning
charcoal briquettes to heat the tobacco, in addition to tobacco combustion products, smokers are exposed to
charcoal combustion products including high levels of carbon monoxide (CO), a potent vasodilator molecule,
shown to mask acute hookah-induced endothelial dysfunction. Long-term cigarette smoking is known to cause
impairment in endothelial and vascular function, and while both cigarette and hookah are vehicles for tobacco,
the comparative effect of long-term hookah smoking is unknown. Accordingly, we now turn our attention to
elucidate the long-term health effect of hookah smoking on endothelial and vascular function; and identify
biomarkers of harm by which chronic hookah smoking affects vascular health. We hypothesize that with long-
term hookah smoking, tobacco combustion products—mainly nicotine, high concentrations of particles,
oxidants—and flavorings predominate and override the vasodilator effects of CO, leading to persistent
endothelial and vascular dysfunction, thereby increasing the risk of future atherosclerosis and cardiovascular
disease. We further hypothesize that the hookah-induced vascular dysfunction is at least in part mediated by
enhanced formation of oxygen-derived free radicals, promoting systemic vascular inflammation and oxidative
stress. To accomplish our goals, in 34 healthy chronic hookah smokers 21-49 years of age who do not smoke
cigarettes—matched for age and sex with 34 cigarette smokers and 34 non-smokers—we will measure: (a)
endothelial function, by brachial artery flow-mediated dilation; and (b) vascular stiffness, by carotid-femoral pulse
wave velocity and aortic augmentation index, as a measure of wave reflection. Biological markers of inflammation
(high sensitivity C-reactive protein, 8-iso-prostaglandin F2α, fibrinogen) and oxidative stress (prooxidant high-
density lipoprotein oxidant index and total antioxidant capacity) will be collected. Because hookah smoking has
outpaced research needed to propose evidence-based regulation, findings will: (a) fill in large gaps in our
understanding of the chronic effects of hookah smoking; and (b) provide a foundation for future long-term studies
to establish the relationship between physiological and systemic biomarkers to specific cardiovascular pathologic
processes, thereby building a scientific basis to inform the currently debated national policy decisions specific to
hookah.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Mary Rezk-Hanna其他文献
Mary Rezk-Hanna的其他文献
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{{ truncateString('Mary Rezk-Hanna', 18)}}的其他基金
Chronic Hookah (Waterpipe) Smoking, Vascular Dysfunction, Inflammation and Oxidative Stress
慢性吸水烟、血管功能障碍、炎症和氧化应激
- 批准号:
10263274 - 财政年份:2020
- 资助金额:
$ 46.55万 - 项目类别:
Investigating The Cardiovascular Toxicity Of Exposure To Electronic Hookah Smoking
研究电子水烟对心血管的毒性
- 批准号:
9647995 - 财政年份:2018
- 资助金额:
$ 46.55万 - 项目类别:
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