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Chronic Hookah (Waterpipe) Smoking, Vascular Dysfunction, Inflammation and Oxidative Stress

慢性吸水烟、血管功能障碍、炎症和氧化应激

基本信息

批准号：
10475100
负责人：
Mary Rezk-Hanna
金额：
$ 46.55万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-15 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10475100
关键词：
Acute Adult Advertisements Affect Age Age-Years Air Pollutants Antioxidants Atherosclerosis Attention Attenuated Back Belief Biological Assay Biological Markers Blood Circulation Blood Vessels C-reactive protein Carbon Monoxide Cardiovascular Diseases Cardiovascular system Charcoal Chronic Cigarette Cigarette Smoker Data Dilator Endothelium Epidemic Exposure to Fibrinogen Filler Flavoring Foundations Free Radicals Fruit Future Gases Goals Health High Density Lipoproteins Impairment Inflammation Long-Term Effects Longitudinal Studies Marketing Masks Measures Mediating Methodology Mythology Nicotine Oxidants Oxidative Stress Oxygen Pathologic Processes Peripheral Physiologic pulse Physiological Plasma Policies Prostaglandins Regulation Research Risk Smoke Smoker Smoking Testing Tobacco Tobacco smoking behavior Tobacco use Vascular Diseases Vasodilation Vasodilator Agents Vasomotor Water Youth arterial stiffness base brachial artery cardiovascular effects cigarette smoking combustion product comparative endothelial dysfunction evidence base experimental study fine particles hookah indexing inflammatory marker men non-cigarette tobacco product non-smoker particle pressure response sex smoking exposure tobacco exposure tobacco flavor tobacco products ultrafine particle vascular inflammation young adult

项目摘要

Project Summary Tobacco smoking using a hookah (waterpipe) is rapidly increasing in popularity worldwide, particularly among youth. The spread of hookah smoking is promoted by the unsubstantiated belief that smoke is detoxified as it passes through the water filled basin; heavy marketing and glamorization of fruit-flavored tobacco products; and lack of policy regulation. Because traditional hookah is the only form of tobacco product that uses burning charcoal briquettes to heat the tobacco, in addition to tobacco combustion products, smokers are exposed to charcoal combustion products including high levels of carbon monoxide (CO), a potent vasodilator molecule, shown to mask acute hookah-induced endothelial dysfunction. Long-term cigarette smoking is known to cause impairment in endothelial and vascular function, and while both cigarette and hookah are vehicles for tobacco, the comparative effect of long-term hookah smoking is unknown. Accordingly, we now turn our attention to elucidate the long-term health effect of hookah smoking on endothelial and vascular function; and identify biomarkers of harm by which chronic hookah smoking affects vascular health. We hypothesize that with long- term hookah smoking, tobacco combustion products—mainly nicotine, high concentrations of particles, oxidants—and flavorings predominate and override the vasodilator effects of CO, leading to persistent endothelial and vascular dysfunction, thereby increasing the risk of future atherosclerosis and cardiovascular disease. We further hypothesize that the hookah-induced vascular dysfunction is at least in part mediated by enhanced formation of oxygen-derived free radicals, promoting systemic vascular inflammation and oxidative stress. To accomplish our goals, in 34 healthy chronic hookah smokers 21-49 years of age who do not smoke cigarettes—matched for age and sex with 34 cigarette smokers and 34 non-smokers—we will measure: (a) endothelial function, by brachial artery flow-mediated dilation; and (b) vascular stiffness, by carotid-femoral pulse wave velocity and aortic augmentation index, as a measure of wave reflection. Biological markers of inflammation (high sensitivity C-reactive protein, 8-iso-prostaglandin F2α, fibrinogen) and oxidative stress (prooxidant high- density lipoprotein oxidant index and total antioxidant capacity) will be collected. Because hookah smoking has outpaced research needed to propose evidence-based regulation, findings will: (a) fill in large gaps in our understanding of the chronic effects of hookah smoking; and (b) provide a foundation for future long-term studies to establish the relationship between physiological and systemic biomarkers to specific cardiovascular pathologic processes, thereby building a scientific basis to inform the currently debated national policy decisions specific to hookah.

项目总结