Chronic Hookah (Waterpipe) Smoking, Vascular Dysfunction, Inflammation and Oxidative Stress

慢性吸水烟、血管功能障碍、炎症和氧化应激

基本信息

批准号：
10475100
负责人：
Mary Rezk-Hanna
金额：
$ 46.55万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-15 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10475100
关键词：
Acute Adult Advertisements Affect Age Age-Years Air Pollutants Antioxidants Atherosclerosis Attention Attenuated Back Belief Biological Assay Biological Markers Blood Circulation Blood Vessels C-reactive protein Carbon Monoxide Cardiovascular Diseases Cardiovascular system Charcoal Chronic Cigarette Cigarette Smoker Data Dilator Endothelium Epidemic Exposure to Fibrinogen Filler Flavoring Foundations Free Radicals Fruit Future Gases Goals Health High Density Lipoproteins Impairment Inflammation Long-Term Effects Longitudinal Studies Marketing Masks Measures Mediating Methodology Mythology Nicotine Oxidants Oxidative Stress Oxygen Pathologic Processes Peripheral Physiologic pulse Physiological Plasma Policies Prostaglandins Regulation Research Risk Smoke Smoker Smoking Testing Tobacco Tobacco smoking behavior Tobacco use Vascular Diseases Vasodilation Vasodilator Agents Vasomotor Water Youth arterial stiffness base brachial artery cardiovascular effects cigarette smoking combustion product comparative endothelial dysfunction evidence base experimental study fine particles hookah indexing inflammatory marker men non-cigarette tobacco product non-smoker particle pressure response sex smoking exposure tobacco exposure tobacco flavor tobacco products ultrafine particle vascular inflammation young adult

项目摘要

Project Summary Tobacco smoking using a hookah (waterpipe) is rapidly increasing in popularity worldwide, particularly among youth. The spread of hookah smoking is promoted by the unsubstantiated belief that smoke is detoxified as it passes through the water filled basin; heavy marketing and glamorization of fruit-flavored tobacco products; and lack of policy regulation. Because traditional hookah is the only form of tobacco product that uses burning charcoal briquettes to heat the tobacco, in addition to tobacco combustion products, smokers are exposed to charcoal combustion products including high levels of carbon monoxide (CO), a potent vasodilator molecule, shown to mask acute hookah-induced endothelial dysfunction. Long-term cigarette smoking is known to cause impairment in endothelial and vascular function, and while both cigarette and hookah are vehicles for tobacco, the comparative effect of long-term hookah smoking is unknown. Accordingly, we now turn our attention to elucidate the long-term health effect of hookah smoking on endothelial and vascular function; and identify biomarkers of harm by which chronic hookah smoking affects vascular health. We hypothesize that with long- term hookah smoking, tobacco combustion products—mainly nicotine, high concentrations of particles, oxidants—and flavorings predominate and override the vasodilator effects of CO, leading to persistent endothelial and vascular dysfunction, thereby increasing the risk of future atherosclerosis and cardiovascular disease. We further hypothesize that the hookah-induced vascular dysfunction is at least in part mediated by enhanced formation of oxygen-derived free radicals, promoting systemic vascular inflammation and oxidative stress. To accomplish our goals, in 34 healthy chronic hookah smokers 21-49 years of age who do not smoke cigarettes—matched for age and sex with 34 cigarette smokers and 34 non-smokers—we will measure: (a) endothelial function, by brachial artery flow-mediated dilation; and (b) vascular stiffness, by carotid-femoral pulse wave velocity and aortic augmentation index, as a measure of wave reflection. Biological markers of inflammation (high sensitivity C-reactive protein, 8-iso-prostaglandin F2α, fibrinogen) and oxidative stress (prooxidant high- density lipoprotein oxidant index and total antioxidant capacity) will be collected. Because hookah smoking has outpaced research needed to propose evidence-based regulation, findings will: (a) fill in large gaps in our understanding of the chronic effects of hookah smoking; and (b) provide a foundation for future long-term studies to establish the relationship between physiological and systemic biomarkers to specific cardiovascular pathologic processes, thereby building a scientific basis to inform the currently debated national policy decisions specific to hookah.

项目摘要使用水烟（Waterpipe）吸烟的烟草吸烟（Waterpipe）在全球范围内迅速增加，尤其是在青年。水烟吸烟的蔓延是由未经证实的信念提倡的穿过充满水的水盆；水果味的烟草产品的大量营销和魅力化；和缺乏政策法规。因为传统的水烟是使用燃烧的烟草产品的唯一形式除烟草混合物产品外，木炭煤气以加热烟草，吸烟者还暴露于木炭组合产品包括高水平的一氧化碳（CO），一种潜在的血管扩张剂分子，显示以掩盖急性水烟引起的内皮功能障碍。已知长期吸烟会引起吸烟内皮和血管功能的损害，虽然香烟和水烟是烟草的车辆，但长期吸烟的比较效应尚不清楚。根据，我们现在将注意力转移到阐明水烟吸烟对内皮和血管功能的长期健康效应；并确定慢性水烟吸烟会影响血管健康的危害生物标志物。我们假设这是长期术语水烟吸烟，烟草混合物产品 - 尼古丁，高浓度颗粒，氧化剂 - 调味剂占主导和覆盖CO的血管舒张作用，导致持续内皮和血管功能障碍，从而增加了未来动脉粥样硬化和心血管的风险疾病。我们进一步假设，水烟引起的血管功能障碍至少部分由增强了氧衍生的自由基的形成，促进全身血管感染和氧化压力。为了实现我们的目标，在34名健康的慢性烟熏吸烟者中21-49岁，不吸烟香烟 - 与34名吸烟者和34位非吸烟者的年龄和性别匹配 - 我们将衡量：（a）内皮功能，由臂动脉流介导的词典由臂动脉介导的词典；（b）颈动脉脉搏波速度和主动脉增强指数，作为波浪反射的度量。炎症的生物标记（高灵敏度C反应性蛋白，8- ISO-ProstaglandinF2α，纤维蛋白酶原）和氧化应激（验证较高 - 高 - 将收集密度脂蛋白氧化剂指数和总抗氧化能力）。因为水烟吸烟有提出基于证据的法规所需的研究将要结束：（a）填补我们的巨大空白了解水烟吸烟的慢性影响；（b）为将来的长期研究提供了基础建立物理和系统生物标志物与特定心血管病理学之间的关系流程，从而建立科学依据，以告知当前辩论的国家政策决策水烟。