Thalamic Circuits for Prosocial Behaviors in Mice

小鼠亲社会行为的丘脑回路

• 批准号: 10475634
• 负责人: Xiaoke Chen
• 金额: $ 46.03万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10475634
• 关键词: Aggressive behavior; Amygdaloid structure; Behavior; Behavioral; Behavioral Paradigm; Cell Nucleus; Child Rearing; Complex; Dependovirus; Desire for food; Diagnosis; Dissection; Distress; Electrophysiology (science); Emotional; FOS gene; Frontotemporal Dementia; Future; Grooming; Health; Hippocampus (Brain); Human; Imaging Device; Implant; Individual; Knowledge; Label; Mediating; Monitor; Motivation; Mus; Neurons; Pair Bond; Pathway interactions; Perception; Pharmacogenetics; Phase; Positioning Attribute; Prefrontal Cortex; Protocols documentation; Research; Rodent; Rodent Model; Role; Series; Social Behavior; Social Interaction; Societies; Stress; Structure of paraventricular nucleus of thalamus; Symptoms; System; Testing; Thalamic structure; Viral; Work; autism spectrum disorder; base; behavior observation; behavior test; experimental study; in vivo; in vivo calcium imaging; knowledge base; motivated behavior; mouse model; neural circuit; neuromechanism; novel; optogenetics; prairie vole; rabies viral tracing; relating to nervous system; response; social; social deficits

Abstract  Social  interactions  are  essential  for  human  health  and  society.    However,  the  neural  circuitry  basis  for  many  social behaviors remains uncertain.  Beside classical behaviors such as aggression, pair bonding and parenting,  recent research has demonstrated that rodents are also capable of behaviors to comfort distressed individuals.   To study the neural basis of these prosocial behaviors, we recently adapted a protocol that produces consolation-­ like  behavior  in  socially  monogamous  prairie  voles  to  the  widely  used  C57BL/6J  mice.  Our  preliminary  experiments  indicate  an  important  role  for  the  paraventricular  nucleus  of  the  thalamus  (PVT)  in  controlling  consolation-­like behavior in mice.  Comforting a distressed cagemate elicited robust c-­Fos expression in the PVT  and  pharmacogenetic  silencing  of  the  PVT  dramatically  reduced  consolation-­like  behavior.    Based  on  these  intriguing results, we propose to (Aim1) perform in vivo electrophysiology recording and optogenetic manipulation  of PVT to determine the role of PVT during consolation-­like behavior. In comforting mice, there was also strong  activation of the prefrontal cortex and ventral subiculum which are major inputs to the PVT. We therefore propose  to (Aim2) identify the inputs responsible for PVT activity during prosocial behavior and expand our understanding  of  the  circuitry  using  viral  tracing.    The  proposed  studies  defining  the  prosocial  neural  circuitry  will  add  to  the  knowledge base necessary for treating conditions with social deficits.

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