Clinical and Translational Pre-doctoral training in Alzheimer's Disease and Related Dementias

阿尔茨海默病和相关痴呆症的临床和转化博士前培训

• 批准号: 10475693
• 负责人: JENNIFER Lynn BIZON
• 金额: $ 7.77万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10475693
• 关键词: Alzheimer' s disease related dementia; Clinical; Training; pre-doctoral

ABSTRACT Alzheimer's disease is a devastating and ultimately fatal neurodegenerative disorder that severely compromises normal cognition and behavior. Costs associated with caring for individuals suffering from AD now exceed 250 billion dollars annually and are expected to rise exponentially in the foreseeable future. Despite this staggering statistic, there exist few treatments and no cures for AD and related dementias. Significant advances in the treatment of AD will require scientists to cross traditional boundaries between disciplines. Indeed, there is increasing recognition that AD is pathologically, genetically, and/or clinically linked to a number of other dementing diseases. Moreover, it is clear that a fuller understanding of how primary risk factors and co- morbidities in AD influence disease progression could reveal novel targets for improving patient outcomes. The overarching goal of this proposal is to build upon outstanding infrastructure for neuroscience training and the vast expertise in AD research at the University of Florida to create a pre-doctoral training program that will foster the development of the next generation of AD researchers and equip them with the broad perspective and scientific skills necessary to make true advances in the treatment of this devastating and complex disease. Trainees for this program will be selected from a pool of outstanding students from diverse backgrounds who are admitted into one of two graduate programs—a biomedical science program and a clinical health psychology program. Trainees would benefit from (1) intensive mentorship in research concepts and methodology, scientific analysis and interpretation (2) opportunities to train and interact with world-class faculty who are leading authorities in the field of AD, aging and co-morbidities of this disease (3) diverse dissertation committees that include multiple mentors with distinct realms of expertise in order to promote broad-based and comprehensive training in AD research (4) assistance integrating large scale, open source data supported by NIA such as AMP- AD and ADNI into their own research (5) personalized mentorship in professional development including grant writing, oral presentations, and networking. Finally, this training program is designed to maximize interactions among trainees and training faculty that cross levels of analysis and to create a rigorous but supportive training environment that will prepare trainees for success in laboratory science and provide them with the knowledge and skills required to make a significant impact in advancing treatments for AD.

摘要 阿尔茨海默氏病是一种毁灭性的，最终致命的神经退行性疾病，严重损害 正常的认知和行为。与照顾AD患者相关的费用现在超过250美元 亿美元，预计在可预见的未来将呈指数级增长。尽管这个惊人的 据统计，AD和相关痴呆症治疗方法很少，且没有治愈方法。大大推进 AD的治疗需要科学家跨越学科之间的传统界限。确实有 越来越多的人认识到AD在病理学、遗传学和/或临床上与许多其他疾病相关， 令人痴呆的疾病。此外，很明显，更全面地了解主要风险因素和共同风险因素是如何产生的， AD发病率影响疾病进展可能揭示改善患者预后的新靶点。的 该提案的总体目标是建立在神经科学培训和 佛罗里达大学在AD研究方面的丰富专业知识，以创建一个博士前培训计划， 培养下一代AD研究人员，使他们具备广阔的视野， 在治疗这种毁灭性和复杂的疾病方面取得真正进展所需的科学技能。 该计划的学员将从来自不同背景的优秀学生中挑选， 被录取进入两个研究生课程之一-生物医学科学课程和临床健康心理学 程序.学员将受益于（1）在研究概念和方法，科学 分析和解释（2）有机会培训和与世界一流的教师谁是领先的互动 AD、衰老和这种疾病的共病领域的权威机构（3）不同的论文委员会， 包括具有不同专门知识领域多位导师，以促进基础广泛和全面的 AD研究培训（4）协助整合由NIA（如AMP）支持的大规模开源数据- AD和ADNI纳入自己的研究（5）个性化的专业发展指导，包括赠款 写作、口头报告和网络。最后，本培训计划旨在最大限度地提高互动 在学员和培训教师中，跨层次的分析，并建立一个严格的，但支持性的培训 环境，将准备学员在实验室科学的成功，并为他们提供的知识 以及在推进AD治疗方面产生重大影响所需的技能。