Clinical and Translational Pre-doctoral training in Alzheimer's Disease and Related Dementias

阿尔茨海默病和相关痴呆症的临床和转化博士前培训

• 批准号: 10228736
• 负责人: JENNIFER Lynn BIZON
• 金额: $ 17.83万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10228736
• 关键词: Alzheimer' s disease related dementia; Clinical; Training; pre-doctoral

ABSTRACT Alzheimer's disease is a devastating and ultimately fatal neurodegenerative disorder that severely compromises normal cognition and behavior. Costs associated with caring for individuals suffering from AD now exceed 250 billion dollars annually and are expected to rise exponentially in the foreseeable future. Despite this staggering statistic, there exist few treatments and no cures for AD and related dementias. Significant advances in the treatment of AD will require scientists to cross traditional boundaries between disciplines. Indeed, there is increasing recognition that AD is pathologically, genetically, and/or clinically linked to a number of other dementing diseases. Moreover, it is clear that a fuller understanding of how primary risk factors and co- morbidities in AD influence disease progression could reveal novel targets for improving patient outcomes. The overarching goal of this proposal is to build upon outstanding infrastructure for neuroscience training and the vast expertise in AD research at the University of Florida to create a pre-doctoral training program that will foster the development of the next generation of AD researchers and equip them with the broad perspective and scientific skills necessary to make true advances in the treatment of this devastating and complex disease. Trainees for this program will be selected from a pool of outstanding students from diverse backgrounds who are admitted into one of two graduate programs—a biomedical science program and a clinical health psychology program. Trainees would benefit from (1) intensive mentorship in research concepts and methodology, scientific analysis and interpretation (2) opportunities to train and interact with world-class faculty who are leading authorities in the field of AD, aging and co-morbidities of this disease (3) diverse dissertation committees that include multiple mentors with distinct realms of expertise in order to promote broad-based and comprehensive training in AD research (4) assistance integrating large scale, open source data supported by NIA such as AMP- AD and ADNI into their own research (5) personalized mentorship in professional development including grant writing, oral presentations, and networking. Finally, this training program is designed to maximize interactions among trainees and training faculty that cross levels of analysis and to create a rigorous but supportive training environment that will prepare trainees for success in laboratory science and provide them with the knowledge and skills required to make a significant impact in advancing treatments for AD.

摘要 阿尔茨海默病是一种毁灭性的、最终致命的神经退行性疾病，它严重损害了 正常的认知和行为。与护理阿尔茨海默病患者相关的费用现在超过250 每年10亿美元，预计在可预见的未来将呈指数级增长。尽管这一点令人震惊 据统计，阿尔茨海默病和相关痴呆的治疗方法很少，也没有根治方法。在这方面取得了重大进展 治疗阿尔茨海默病需要科学家跨越不同学科之间的传统界限。事实上，有 越来越多的人认识到阿尔茨海默病在病理上、基因上和/或临床上与许多其他 精神错乱的疾病。此外，很明显，更充分地了解主要风险因素和共同风险是如何 AD的发病率影响疾病进展，可以揭示改善患者预后的新靶点。这个 这项提议的总体目标是建立在神经科学培训和 在佛罗里达大学的AD研究方面拥有丰富的专业知识，以创建一个博士前培训计划，将促进 下一代AD研究人员的发展，并使他们具有广阔的视野和 在治疗这种毁灭性而复杂的疾病方面取得真正进展所需的科学技能。 该项目的实习生将从来自不同背景的优秀学生中挑选出来 被两个研究生项目之一录取-生物医学科学项目和临床健康心理学 程序。受训者将受益于(1)在研究概念和方法、科学 分析和解释(2)培训和与领导世界一流的教师互动的机会 阿尔茨海默病、衰老和该病共病领域的权威(3)不同的论文委员会， 包括具有不同专业领域的多名导师，以促进基础广泛和全面的 AD研究培训(4)帮助集成由NIA支持的大规模开源数据，如AMP- AD和ADNI进入他们自己的研究(5)在专业发展方面的个性化指导，包括赠款 写作、口头陈述和网络交流。最后，本培训计划旨在最大限度地实现互动 在实习生和培训人员中，跨层次分析并创建严格但支持性的培训 将为学员在实验室科学领域取得成功做好准备并为他们提供知识的环境 以及在推进AD治疗方面产生重大影响所需的技能。