Clinical and Translational Pre-doctoral training in Alzheimer's Disease and Related Dementias

阿尔茨海默病和相关痴呆症的临床和转化博士前培训

• 批准号: 10228736
• 负责人: JENNIFER Lynn BIZON
• 金额: $ 17.83万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10228736
• 关键词: Alzheimer' s disease related dementia; Clinical; Training; pre-doctoral

ABSTRACT Alzheimer's disease is a devastating and ultimately fatal neurodegenerative disorder that severely compromises normal cognition and behavior. Costs associated with caring for individuals suffering from AD now exceed 250 billion dollars annually and are expected to rise exponentially in the foreseeable future. Despite this staggering statistic, there exist few treatments and no cures for AD and related dementias. Significant advances in the treatment of AD will require scientists to cross traditional boundaries between disciplines. Indeed, there is increasing recognition that AD is pathologically, genetically, and/or clinically linked to a number of other dementing diseases. Moreover, it is clear that a fuller understanding of how primary risk factors and co- morbidities in AD influence disease progression could reveal novel targets for improving patient outcomes. The overarching goal of this proposal is to build upon outstanding infrastructure for neuroscience training and the vast expertise in AD research at the University of Florida to create a pre-doctoral training program that will foster the development of the next generation of AD researchers and equip them with the broad perspective and scientific skills necessary to make true advances in the treatment of this devastating and complex disease. Trainees for this program will be selected from a pool of outstanding students from diverse backgrounds who are admitted into one of two graduate programs—a biomedical science program and a clinical health psychology program. Trainees would benefit from (1) intensive mentorship in research concepts and methodology, scientific analysis and interpretation (2) opportunities to train and interact with world-class faculty who are leading authorities in the field of AD, aging and co-morbidities of this disease (3) diverse dissertation committees that include multiple mentors with distinct realms of expertise in order to promote broad-based and comprehensive training in AD research (4) assistance integrating large scale, open source data supported by NIA such as AMP- AD and ADNI into their own research (5) personalized mentorship in professional development including grant writing, oral presentations, and networking. Finally, this training program is designed to maximize interactions among trainees and training faculty that cross levels of analysis and to create a rigorous but supportive training environment that will prepare trainees for success in laboratory science and provide them with the knowledge and skills required to make a significant impact in advancing treatments for AD.

抽象的 阿尔茨海默氏病是一种毁灭性的，最终是致命的神经退行性疾病，严重损害了 正常的认知和行为。与关心患有广告的人相关的成本超过250 每年十亿美元，预计在可预见的将来将成倍增长。尽管这么惊人 统计数据，对AD和相关痴呆症的治疗很少，也没有治疗方法。在 AD的处理将要求科学家在学科之间跨越传统界限。确实，有 越来越多地认识到AD在病理，一般和/或临床上与许多其他相关 痴呆疾病。此外，很明显，对主要风险因素和共同的主要风险因素和共同点有更深入的了解 AD的病态影响疾病进展可能揭示了改善患者预后的新目标。这 该提案的总体目标是建立在神经科学培训的杰出基础设施基础上 佛罗里达大学广泛的广告研究专业知识，以创建博士前培训计划，以培养 下一代广告研究人员的发展，并为他们提供广泛的观点和 在治疗这种毁灭性和复杂疾病方面取得真正进步所必需的科学技能。 该计划的受训者将从来自潜水员背景的杰出学生群中选出 被录取为两个研究生课程之一 - 一项生物医学科学计划和临床健康心理学 程序。受训者将受益于（1）研究概念和方法论，科学方面的密集程度。 分析和解释（2）与领导世界一流的教师培训和互动的机会 该疾病的广告，衰老和合并症领域的当局（3）潜水学论文委员会 包括具有不同专业知识领域的多个导师，以促进基于广泛的综合性 AD研究的培训（4）协助整合了由NIA支持的大规模开源数据，例如AMP- AD和ADNI进入自己的研究（5）专业发展的个性化精神，包括Grant 写作，口头演示和网络。最后，该培训计划旨在最大化互动 在学员和培训教师中，分析并创建严格但支持的培训 将为实验室科学成功的受训者做好准备并为他们提供知识的环境 以及对推进AD治疗的重大影响所需的技能。