Basal forebrain and cognitive aging: Novel experimental and theraptutic avenues
Basal forebrain and cognitive aging: Novel experimental and theraptutic avenues
批准号:
8180233
负责人:
JENNIFER Lynn BIZON
金额:
$27.26万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2007
资助国家:
美国
项目状态:
已结题
起止时间:
2007-08-01 至 2012-05-31
关键词:
AcetylcholineAcheAdoptedAffectAgeAge-associated memory impairmentAgingAging-Related ProcessAlzheimer&aposs DiseaseAttenuatedBiochemicalButyric AcidsCessation of lifeCholinergic ReceptorsClinicalClinical TreatmentCognitionCognitiveCognitive agingCognitive deficitsConfocal MicroscopyDataDiagnosisDiscriminationDiscrimination LearningDiseaseEarly DiagnosisElderlyExhibitsExperimental DesignsFigs - dietaryFunctional disorderGABA AgentsGABA-B ReceptorHippocampus (Brain)HomeostasisHumanImpaired cognitionImpairmentIndividualIndividual DifferencesInvestigationLaboratoriesLearningLongevityMeasuresMedialMemoryMemory LossModelingMorphologyMuscarinic Acetylcholine ReceptorMuscarinicsNeurobiologyNeuronal DysfunctionNeuronsOdorsPathway interactionsPerformancePharmaceutical PreparationsPhenotypePopulationPreparationProcessPropertyProteinsQuality of lifeRattusReceptor SignalingRegimenReportingReproducibilityResearchResearch PersonnelRodentRodent ModelShort-Term MemorySignal TransductionSliceStagingStructureSynapsesSynaptic TransmissionSystemTechniquesTemporal LobeTestingTimeTrainingUnited Statesage relatedagedbasal forebraincholinergiccholinergic neuroncognitive functioncohorteffective therapyefficacy testingexpectationgamma-Aminobutyric Acidimprovedinhibitor/antagonistinterestmalemiddle agemild neurocognitive impairmentneural circuitnovelprogramsreceptorreceptor expressiontransmission processyoung adult
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