UW Core Center for Clinical Research of Musculoskeletal Conditions

我们CCCR的总体目标是开发和提供科学严谨，最先进的方法 和资源进行肌肉骨骼临床研究，从而扩大社区， 研究人员进行高质量的肌肉骨骼临床研究， 为研究人员、临床医生、患者和政策制定者提供有用的数据。在第一个供资周期 对于我们的CCCR，我们成功地与大量的肌肉骨骼临床研究人员合作，介绍了 新的方法和数据集。通过多个专注于肌肉骨骼疾病的项目， 由各种实体（NIH，AHRQ和PCRI）资助，我们在华盛顿大学（UW）的小组已经 积累了丰富的经验和专业知识，进行大型临床有效性试验， 将常规临床数据转化为研究数据。我们开发了最先进的方法， 积累了相当数量的清洁，可分析的数据，供肌肉骨骼研究人员使用。 由于我们的专业知识和资源，我们处于有利地位，以推进我们的UW核心中心的临床 研究（CCCR）在肌肉骨骼疾病，华盛顿大学临床学习，证据和研究（CLEAR） 肌肉骨骼疾病中心。我们UW CCCR的具体目标是：1）继续改进方法 对于临床肌肉骨骼研究，侧重于验证性学习方法（研究设计 观察研究和临床试验）和预测学习方法（人工智能 图像处理和电子健康记录[EHR]数据，包括结构化和非结构化自由文本）; 2)继续提供分析就绪数据集和服务的资源核心 临床肌肉骨骼研究;以及3）继续提供全面的行政核心， 领导CCCR，管理CCCR的财务方面，提供沟通和 与肌肉骨骼研究人员的联系，并评估我们的努力是否成功。通过实现这些 目标是，我们将改善对专业知识和研究质量数据的获取，通过开发改进分析 分析临床数据的方法和管道，并应用和传播有关 进行严格的临床试验。我们的CCCR将能够为卫生系统提供有用的研究数据 决策者将能够将研究结果应用于现实世界的决策。通过实现 为了实现这些目标，我们将促进卫生保健提供系统向真正的学习型卫生保健系统过渡。 最后，重要的是，我们将与培训计划合作，培训下一代的调查人员， 上述方法和途径。

The overall aim of our CCCR is to develop and provide scientifically rigorous, state-of-the-art methods and resources for conducting musculoskeletal clinical research, thereby expanding the community of investigators performing high-quality musculoskeletal clinical research and increasing the amount of available useful data for researchers, clinicians, patients and policy makers. During the first funding cycle for our CCCR, we successfully engaged with a large cohort of musculoskeletal clinical researchers, introducing them to new methods and datasets. Through multiple projects focused on musculoskeletal conditions and funded by a variety of entities (NIH, AHRQ and PCORI), our group at the University of Washington (UW) has accumulated extensive experience and expertise performing large, clinical, effectiveness trials and transforming routine clinical data into research-ready data. We have developed state-of-the-art methods and accumulated a sizeable amount of cleaned, analyzable data to be used by musculoskeletal researchers. Because of our expertise and resources, we are well-positioned to advance our UW Core Center for Clinical Research (CCCR) in Musculoskeletal Diseases, the UW Clinical Learning, Evidence, And Research (CLEAR) Center for Musculoskeletal Disorders. Our UW CCCR Specific Aims are: 1) Continue to improve methods for clinical musculoskeletal studies, focusing on confirmatory learning methods (study design for both observational studies and clinical trials) and predictive learning methods (artificial intelligence for image processing and electronic health record [EHR] data, both structured and unstructured free text); 2) Continue a Resource Core that provides analysis-ready data sets and services for conducting clinical musculoskeletal research; and 3) Continue an Administrative Core that provides overall leadership for the CCCR, manages the financial aspects of the CCCR, provides communication and outreach to musculoskeletal researchers, and evaluates the success of our efforts. By achieving these aims, we will improve access to expertise and research-quality data, improve analytics by developing methods and pipelines for the analysis of clinical data, and apply and disseminate knowledge regarding the conduct of rigorous clinical trials. Our CCCR will be able to provide useful research data to health system decision-makers who will then be able to apply the results of the research to real-world decisions. By achieving these aims, we will facilitate the transition of health care delivery systems to true learning health care systems. Finally, and importantly, we will work with training programs to train the next generation of investigators in the methods and approaches outlined above.