UW Core Center for Clinical Research (CCCR) of Musculoskeletal Conditions

华盛顿大学肌肉骨骼疾病临床研究核心中心 (CCCR)

• 批准号: 9979758
• 负责人: JEFFREY G JARVIK
• 金额: $ 73.87万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-21 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9979758
• 关键词: Address; Archives; Area; Big Data; Clinical; Clinical Data; Clinical Informatics; Clinical Research; Clinical Trials; Clinical effectiveness; Collaborations; Collection; Communication; Communities; Complex; Computerized Medical Record; Data; Data Set; Databases; Development; Electronic Health Record; Ensure; Fostering; Funding; Goals; Health; Health system; Healthcare Systems; Image; Improve Access; Individual; Knowledge; Lead; Leadership; Learning; Methodology; Methods; Musculoskeletal; Musculoskeletal Diseases; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Observational Study; Occupational activity of managing finances; Patients; Policy Maker; Population; Positioning Attribute; Pragmatic clinical trial; Public Health; Published Comment; Quality of Care; Randomized; Recovery; Research; Research Activity; Research Design; Research Personnel; Resources; SECTM1 gene; Scientist; Services; Structure; Surveys; System; Text; Training; Training Programs; United States Agency for Healthcare Research and Quality; United States National Institutes of Health; Universities; Visit; Washington; Work; analysis pipeline; clinical care; clinical center; cost; design; effectiveness clinical trial; effectiveness trial; experience; health care delivery; image processing; improved; next generation; novel; novel strategies; operation; outreach; prevent; programs; success; virtual

The overall aim of our CCCR is to develop and provide scientifically rigorous, state-of-the-art methods and resources for conducting musculoskeletal clinical research, thereby expanding the community of investigators performing high-quality musculoskeletal clinical research and thus increasing the amount of available useful data for researchers, clinicians, patients and policy makers. Over the past decade, health care systems having become increasingly integrated and use electronic health record systems that are collecting and archiving comprehensive and complex sets of data on large populations. While the potential for using such “big data” to address a wide range of health-related questions is enormous, there are substantial obstacles that prevent researchers from accessing and analyzing routine clinical data. Through multiple projects focused on musculoskeletal conditions and funded by a variety of entities (NIH, AHRQ and PCORI), our group at the University of Washington (UW) has accumulated extensive experience and expertise performing large, clinical, effectiveness trials and transforming routine clinical data into research-ready data. We have both developed methods and also have accumulated a sizeable amount of cleaned and analyzable data. Because of our expertise and resources, we believe that we are well-positioned to propose a UW Core Center for Clinical Research (CCCR) in Musculoskeletal Diseases. Our UW CCCR Specific Aims are: 1) Establish a Methodologic Core that will improve methods for clinical musculoskeletal studies that use rigorous and novel study designs, pragmatic/effectiveness clinical trial, and electronic medical records (EMRs); 2) Establish a Resource Core that will provide analysis-ready data sets and services for conducting clinical musculoskeletal research; and 3) Establish an Administrative Core that will provide overall leadership for the CCCR, manage the financial aspects of the CCCR so that it is a sustainable entity, provide communication and outreach to musculoskeletal researchers and evaluate the success of our efforts. By achieving these aims, we will improve access to expertise and research-quality data, we will improve analytics by developing methods and pipelines for the analysis of clinical data, and we will apply and disseminate knowledge regarding the conduct of rigorous clinical trials. By integrating the viewpoints of stakeholders, our CCCR will be able to provide useful research data to health system decision-makers who will apply the results of the research to real-world decisions. By achieving these aims, we will facilitate health care delivery systems becoming true learning health care systems. Finally and perhaps most importantly, we will work with training programs (K12, KL2, R25 and T32) to train the next generation of investigators in the methods and approaches outlined above.

我们CCCR的总体目标是开发和提供科学严谨，最先进的方法 和资源进行肌肉骨骼临床研究，从而扩大社区， 研究人员进行高质量的肌肉骨骼临床研究，从而增加 为研究人员、临床医生、患者和政策制定者提供大量有用的数据。过去 十年来，医疗保健系统越来越多地集成和使用电子健康记录系统 收集和归档大量人口的综合和复杂的数据。而 使用这种“大数据”来解决广泛的健康相关问题的潜力是巨大的， 这些障碍阻碍了研究人员访问和分析常规临床数据。通过 多个项目侧重于肌肉骨骼条件和资助的各种实体（美国国立卫生研究院，AHRQ和 PCRI），我们在华盛顿大学（UW）的团队积累了丰富的经验和专业知识 进行大型临床有效性试验，并将常规临床数据转化为研究数据。 我们既开发了方法，也积累了相当数量的清洁和分析 数据由于我们的专业知识和资源，我们相信我们有能力提出一个UW核心 肌肉骨骼疾病临床研究中心（CCCR）。我们的UW CCCR具体目标是：1） 建立一个方法学核心，将改善临床肌肉骨骼研究的方法， 严谨新颖的研究设计、实用/有效的临床试验和电子病历 2）建立一个资源核心，为以下方面提供分析就绪的数据集和服务： 开展临床肌肉骨骼研究;以及3）建立一个管理核心， 全面领导CCCR，管理CCCR的财务方面，使其成为一个可持续的 实体，为肌肉骨骼研究人员提供沟通和推广，并评估成功 我们的努力。通过实现这些目标，我们将改善对专业知识和研究质量数据的获取，我们将 通过开发用于分析临床数据的方法和管道来改进分析，我们将应用和 传播有关开展严格临床试验的知识。通过整合的观点， 我们的CCCR将能够为卫生系统决策者提供有用的研究数据， 将研究结果应用于现实世界的决策。通过实现这些目标， 提供系统成为真正的学习医疗保健系统。最后，也许是最重要的，我们将 与培训计划（K12，KL 2，R25和T32）合作，培训下一代研究人员 上述方法和途径。