UW Core Center for Clinical Research (CCCR) of Musculoskeletal Conditions

我们CCCR的总体目标是开发和提供科学严谨的、最先进的方法 和资源进行肌肉骨骼临床研究，从而扩大社区 研究人员进行高质量的肌肉骨骼临床研究，从而增加 为研究人员、临床医生、患者和政策制定者提供大量有用的数据。在过去的时间里 十年来，医疗保健系统变得越来越一体化，并使用电子健康记录系统 他们正在收集和归档关于大量人口的全面和复杂的数据集。而当 利用这样的“大数据”来解决广泛的健康相关问题的潜力是巨大的，有 阻碍研究人员访问和分析常规临床数据的重大障碍。穿过 多个项目侧重于肌肉骨骼状况，并由各种实体(NIH、AHRQ和 )，我们在华盛顿大学(UW)的团队积累了丰富的经验和专业知识 进行大型临床有效性试验，并将常规临床数据转换为可供研究的数据。 我们既开发了方法，也积累了相当数量的净化和分析 数据。由于我们的专业知识和资源，我们相信我们有能力提出UW核心 肌肉骨骼疾病临床研究中心。我们UW CCCR的具体目标是：1) 建立方法学核心将改进临床肌肉骨骼研究的方法 严谨新颖的研究设计、务实有效的临床试验和电子病历 (EMRS)；2)建立资源核心，为以下项目提供可供分析的数据集和服务 进行临床肌肉骨骼研究；以及3)建立一个行政核心，以提供 全面领导CCCR，管理CCCR的财务方面，使其成为可持续的 实体，为肌肉骨骼研究人员提供沟通和外展，并评估成功 我们的努力。通过实现这些目标，我们将改善获得专业知识和研究质量数据的机会，我们将 通过开发用于分析临床数据的方法和管道来改进分析，我们将应用和 传播有关进行严格临床试验的知识。通过整合以下观点 利益相关者，我们的CCCR将能够向卫生系统决策者提供有用的研究数据，他们将 将研究结果应用于现实世界的决策。通过实现这些目标，我们将促进医疗保健 提供系统成为真正的学习卫生保健系统。最后，或许最重要的是，我们将 与培训方案(K12、KL2、R25和T32)合作，培训下一代调查人员 以上概述的方法和途径。

The overall aim of our CCCR is to develop and provide scientifically rigorous, state-of-the-art methods and resources for conducting musculoskeletal clinical research, thereby expanding the community of investigators performing high-quality musculoskeletal clinical research and thus increasing the amount of available useful data for researchers, clinicians, patients and policy makers. Over the past decade, health care systems having become increasingly integrated and use electronic health record systems that are collecting and archiving comprehensive and complex sets of data on large populations. While the potential for using such “big data” to address a wide range of health-related questions is enormous, there are substantial obstacles that prevent researchers from accessing and analyzing routine clinical data. Through multiple projects focused on musculoskeletal conditions and funded by a variety of entities (NIH, AHRQ and PCORI), our group at the University of Washington (UW) has accumulated extensive experience and expertise performing large, clinical, effectiveness trials and transforming routine clinical data into research-ready data. We have both developed methods and also have accumulated a sizeable amount of cleaned and analyzable data. Because of our expertise and resources, we believe that we are well-positioned to propose a UW Core Center for Clinical Research (CCCR) in Musculoskeletal Diseases. Our UW CCCR Specific Aims are: 1) Establish a Methodologic Core that will improve methods for clinical musculoskeletal studies that use rigorous and novel study designs, pragmatic/effectiveness clinical trial, and electronic medical records (EMRs); 2) Establish a Resource Core that will provide analysis-ready data sets and services for conducting clinical musculoskeletal research; and 3) Establish an Administrative Core that will provide overall leadership for the CCCR, manage the financial aspects of the CCCR so that it is a sustainable entity, provide communication and outreach to musculoskeletal researchers and evaluate the success of our efforts. By achieving these aims, we will improve access to expertise and research-quality data, we will improve analytics by developing methods and pipelines for the analysis of clinical data, and we will apply and disseminate knowledge regarding the conduct of rigorous clinical trials. By integrating the viewpoints of stakeholders, our CCCR will be able to provide useful research data to health system decision-makers who will apply the results of the research to real-world decisions. By achieving these aims, we will facilitate health care delivery systems becoming true learning health care systems. Finally and perhaps most importantly, we will work with training programs (K12, KL2, R25 and T32) to train the next generation of investigators in the methods and approaches outlined above.