Administrative Core for Institution # 269291

摘要 中央行政和管理核心(CAMC)的主要目标是充当支柱和 为坦普尔大学综合神经艾滋病毒中心(CNHC)提供行政监督 费城的德雷克塞尔大学。总体目标是改进和扩大与神经艾滋病毒相关的研究。 以及与中枢神经系统病毒感染相关的神经疾病，包括神经行为障碍和 精神错乱。CNHC在过去10年创建的基础设施提供了独特的专业知识 当地、地区和国家的神经艾滋病毒调查人员，专注于我们在基因编辑和交付方面的优势， 哺乳动物祖细胞和IPSC培养，协助研究人员对感染病毒的细胞进行遗传分析 前后编辑程序，并支持全方位最先进的显微和成像 分析。同时，CNHC将协调神经艾滋病毒社区伙伴关系和差异核心 影响PWH，新开发的核心，现在包括在我们的计划中。民航局将协助联络 与现有和潜在的社区合作伙伴共同促进患者群体和 参与式研究人员。TKHE中心提供其在功能细胞分析方面的独特专业知识，包括 微电极阵列技术用于研究神经细胞对外界应激的反应。此外， 该中心将使研究人员能够启动临床和神经行为检查，并建立一个良好的队列 在德雷克塞尔大学医学院对艾滋病毒(PWH)患者进行纵向检查。中国航空航天委员会将 提供基础设施，以协调和监督CNHC的所有活动，并促进协同 核心和其他NIMH支持的中心之间的交互。军委将制定战略规划， 确定短期和长期目标，执行要实施的详细计划，进行内部和外部 基于既定标准的审查和评估工具，以确保有成效和高效地使用资源 为实现CNHC的总体目标。它还将为数据分析和 从基础科学和临床核心获得的解释。此外，这一核心将与 科学核心向参与者和核心用户传播信息，招募核心用户， 试点应用程序，对核心产生的所有原始数据进行编目，促进和跟踪所有分发的材料 按核心，包括但不限于细胞系、病毒库和临床标本。

SUMMARY The main objective of the Central Administrative and Management Core (CAMC) is to serve as the anchor and to provide administrative oversight for the Comprehensive NeuroHIV Center (CNHC) at Temple University and Drexel University in Philadelphia. The overall objective is to improve and expand research related to neuroHIV and neurological diseases associated with viral infection of the CNS including neurobehavioral impairment and mental disorders. The infrastructure created by the CNHC during the last 10 years offers unique expertise to local, regional, and national neuroHIV investigators with focus on our strengths of gene editing and delivery, mammalian progenitor cells and iPSC cultures, assist investigators with genetic analysis of virus-infected cells before and after editing procedures, and support for a full-range of state-of-the-art microscopic and imaging analysis. At the same time, the CNHC will coordinate the NeuroHIV Community Partnership and Disparity Core affecting PWH, the newly developed core that is now included in our program. The CAMC will assist with liaising with current and potential community partners in fostering synergy among the patient population and the participant researchers. Tkhe Center offers its unique expertise in functional cellular assays including microelectrode array assay to study neuronal cell behavior in response to external stress. Furthermore, the Center will enable investigators to initiate clinical and neurobehavioral examination with a well-established cohort of people with HIV (PWH) longitudinally examined at Drexel University College of Medicine. The CAMC will provide the infrastructure for coordinating and overseeing all activities of the CNHC and facilitating synergistic interaction among the cores and other NIMH-supported Centers. The CAMC will delineate the strategic plan, identify short- and long-term objectives, execute detailed plans to be implemented, carry out internal and external reviews and assessment tools based on established criteria to ensure productive and efficient use of resources to achieve the overall objectives of the CNHC. It will also offer biostatistical support for data analysis and interpretation obtained from the basic science and clinical cores. In addition, this Core will coordinate with the Scientific Cores to disseminate information to the participants as well as Core users, recruit Core users, solicitate pilot applications, catalogue all original data generated by the Cores, facilitate and track all material distributed by the Cores, including, but not limited to, cell lines, viral stocks, and clinical specimens.