Administrative Core for Institution # 269291

机构行政核心

• 批准号: 10475406
• 负责人: Kamel Khalili
• 金额: $ 25万
• 依托单位: TEMPLE UNIV OF THE COMMONWEALTH
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-05 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10475406
• 关键词: Accountability; Acquired Immunodeficiency Syndrome; Affect; Area; Assessment tool; Award; Basic Science; Biological Assay; Biometry; Cataloging; Catalogs; Cell Line; Cells; Cellular Assay; Central Nervous System Viral Diseases; Cities; Clinic; Clinical; Collaborations; Collection; Communicable Diseases; Communication; Communities; Country; Data; Data Analyses; Data Collection; Development; Educational workshop; Ensure; Evaluation; Fostering; Funding; Genes; Goals; Grant; HIV; HIV-1; Impairment; Individual; Infrastructure; Institutes; Institution; International; Laboratory Research; Leadership; Learning; Measures; Medicine; Mental disorders; Mentorship; Microelectrodes; Mission; National Institute of Mental Health; Neurology; Neurons; Neurosciences; Office of Administrative Management; Outcome; Participant; Performance; Persons; Philadelphia; Physicians; Play; Procedures; Process; Productivity; Reporting; Research; Research Personnel; Research Support; Resources; Role; Scientist; Seeds; Self Assessment; Series; Societies; Source; Specimen; Strategic Planning; Stress; Time; United States National Institutes of Health; Universities; Update; Viral; Virus; base; cell behavior; cohesion; cohort; college; community partnership; genetic analysis; graduate student; improved; induced pluripotent stem cell; interest; microscopic imaging; nervous system disorder; neuroAIDS; neurobehavioral; operation; patient population; programs; recruit; response; stem cells; symposium; synergism; tool

SUMMARY The main objective of the Central Administrative and Management Core (CAMC) is to serve as the anchor and to provide administrative oversight for the Comprehensive NeuroHIV Center (CNHC) at Temple University and Drexel University in Philadelphia. The overall objective is to improve and expand research related to neuroHIV and neurological diseases associated with viral infection of the CNS including neurobehavioral impairment and mental disorders. The infrastructure created by the CNHC during the last 10 years offers unique expertise to local, regional, and national neuroHIV investigators with focus on our strengths of gene editing and delivery, mammalian progenitor cells and iPSC cultures, assist investigators with genetic analysis of virus-infected cells before and after editing procedures, and support for a full-range of state-of-the-art microscopic and imaging analysis. At the same time, the CNHC will coordinate the NeuroHIV Community Partnership and Disparity Core affecting PWH, the newly developed core that is now included in our program. The CAMC will assist with liaising with current and potential community partners in fostering synergy among the patient population and the participant researchers. Tkhe Center offers its unique expertise in functional cellular assays including microelectrode array assay to study neuronal cell behavior in response to external stress. Furthermore, the Center will enable investigators to initiate clinical and neurobehavioral examination with a well-established cohort of people with HIV (PWH) longitudinally examined at Drexel University College of Medicine. The CAMC will provide the infrastructure for coordinating and overseeing all activities of the CNHC and facilitating synergistic interaction among the cores and other NIMH-supported Centers. The CAMC will delineate the strategic plan, identify short- and long-term objectives, execute detailed plans to be implemented, carry out internal and external reviews and assessment tools based on established criteria to ensure productive and efficient use of resources to achieve the overall objectives of the CNHC. It will also offer biostatistical support for data analysis and interpretation obtained from the basic science and clinical cores. In addition, this Core will coordinate with the Scientific Cores to disseminate information to the participants as well as Core users, recruit Core users, solicitate pilot applications, catalogue all original data generated by the Cores, facilitate and track all material distributed by the Cores, including, but not limited to, cell lines, viral stocks, and clinical specimens.

概括 中央行政和管理核心（CAMC）的主要目标是充当支柱和 为天普大学综合神经艾滋病毒中心 (CNHC) 提供行政监督 费城德雷塞尔大学。总体目标是改进和扩大与神经艾滋病毒相关的研究 与中枢神经系统病毒感染相关的神经系统疾病，包括神经行为障碍和 精神障碍。 CNHC 在过去 10 年中创建的基础设施为 地方、区域和国家神经艾滋病毒研究人员重点关注我们在基因编辑和传递方面的优势， 哺乳动物祖细胞和 iPSC 培养物，协助研究人员对病毒感染的细胞进行遗传分析 编辑程序之前和之后，并支持全方位最先进的显微镜和成像 分析。同时，CNHC 将协调 NeuroHIV 社区伙伴关系和差异核心 影响 PWH，这是新开发的核心，现已包含在我们的计划中。 CAMC将协助联络 与当前和潜在的社区合作伙伴一起促进患者群体和社区之间的协同作用 参与研究人员。 Tkhe 中心在功能性细胞检测方面提供独特的专业知识，包括 微电极阵列分析用于研究神经元细胞响应外部压力的行为。此外， 该中心将使研究人员能够利用完善的队列启动临床和神经行为检查 德雷塞尔大学医学院对艾滋病毒感染者 (PWH) 进行了纵向检查。中工机电将 提供协调和监督 CNHC 的所有活动并促进协同作用的基础设施 核心与其他 NIMH 支持的中心之间的互动。 CAMC将制定战略计划， 确定短期和长期目标，执行要实施的详细计划，开展内部和外部活动 基于既定标准的审查和评估工具，以确保资源的高效利用 以实现中国核工业集团公司的总体目标。它还将为数据分析和提供生物统计支持 从基础科学和临床核心获得的解释。此外，该核心将与 科学核心向参与者和核心用户传播信息，招募核心用户，征求 试点应用程序，对核心生成的所有原始数据进行分类，促进和跟踪分发的所有材料 由核心提供，包括但不限于细胞系、病毒储液和临床标本。