Comprehensive NeuroAIDS Core Center

综合神经艾滋病核心中心

• 批准号: 8210493
• 负责人: Kamel Khalili
• 金额: $ 164.42万
• 依托单位: TEMPLE UNIV OF THE COMMONWEALTH
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-05 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8210493
• 关键词: Comprehensive; NeuroAIDS; Core; Center

This revised application seeks support to establish a Comprehensive NeuroAIDS Core Center (CNACC) at the Temple University School of Medicine in order to bring highly needed infrastructure for basic scientists and clinicians involved in HIV-1/AIDS research and neurological, neurodegenerative, and neurobehavioral disorders. The central theme of CNACC is structured based on our hypothesis that understanding the mechanisms of HIV-1/CNS interactions at the molecular, cellular, and experimental animal model levels and bidirectional communication of laboratory findings and clinical observations to validate basic science discoveries are prerequisites for the development of effective, safe, and reliable approaches for early diagnostics and therapeutics for AIDS-associated neurological dysfunctions. The CNACC will provide unprecedented infrastructure to a large group of neuroAIDS investigators who plan to pursue their objectives using multidisciplinary approaches in cell culture, small animal models, and in the clinical setting for assessing gene expression and biomarker identification at the cellular and molecular levels. Further, through the Developmental Core, the CNACC will provide a unique opportunity for training and mentoring of junior and clinical investigators and attract and develop physician scientists in the field of neuroAIDS. Through CNACC, we will provide start-up funds for new and innovative pilot projects of newly recruited, independent investigators and will support feasibility studies for more established neuroAIDS investigators. The funding through this center will create a unique infrastructure that will serve to enhance and extend the effectiveness of ongoing HIV-1 investigations and promote translational research in neuroAIDS at Temple and other medical institutions in the greater Philadelphia area that are involved in basic science and clinical AIDS research. With its comprehensive structural organization encompassing broadly based cores ranging from molecular biology to experimental animals to the clinical arena directed by skilled and highly competent investigators from various disciplines, CNACC will support research in a variety of areas such as virology, basic and behavioral neuroscience, and clinical science, all of which are aimed toward the discovery of better diagnostics and effective therapeutic agents toward AIDS/CNS disorders.

该修订后的应用程序寻求支持，以在坦普尔大学医学院建立一个全面的神经辅助核心中心（CNACC），以便为参与HIV-1/AIDS研究和神经系统，神经退行性的基础科学家和临床医生带来急需的基础设施。 CNACC的核心主题是根据我们的假设结构的，即在分子，细胞和实验性动物模型水平上了解HIV-1/CNS相互作用的机制，以及实验室发现和临床观察的双向沟通​​，以验证基本科学发现的基础科学发现是有效的，可靠的，可靠的和可靠的诊断方法的前提。 CNACC将向一大批神经辅助研究人员提供前所未有的基础设施，他们计划使用细胞培养中的多学科方法，小动物模型以及评估细胞和分子水平上的基因表达和生物标记鉴定的临床环境来追求其目标。此外，通过发展核心，CNACC将为培训和指导初级和临床研究人员提供独特的机会，并吸引和发展神经辅助领域的医师科学家。通过CNACC，我们将为新招募的独立研究人员的新创新试点项目提供启动资金，并将支持更既定的神经辅助研究人员的可行性研究。通过该中心的资金将创建一个独特的基础设施，该基础设施将有助于增强和扩大正在进行的HIV-1调查的有效性，并促进大费城地区的神经辅助工具的转化研究，并涉及基础科学和临床艾滋病研究的大费城地区。 CNACC凭借其全面的结构组织，涵盖了从分子生物学到实验动物到实验性动物再到来自各个学科的熟练且高度胜任的研究人员指导的临床领域的广泛基础，CNACC将支持在病毒学，基本和行为神经科学以及临床科学等各种领域的研究，这些研究旨在朝着临床方面的诊断和有效的诊断范围和有效的诊断范围。