51st to 55th ANNUAL INTERNATIONAL NARCOTICS RESEARCHCONFERENCES

摘要 国际麻醉品研究会议(INRC)是世界上最重要的科学家组织 致力于阿片类药物的研究。对毒品和成瘾的研究进展迅速，具有开创性 神经科学和受体结构生物学的新技术。INRC每年召开一次会议，每年 传播和协调这一重要和创新信息的总理会议。在 INRC会议介绍了内源性阿片类药物领域的最新研究进展， 阿片受体、阿片类药物药理学、阿片类药物耐受性、依赖性和成瘾以及与 其他神经递质系统，特别是在阿片系统被认为是成瘾的中枢之后 对多种物质的影响。这项基础科学是为转化为临床铺平道路的 疼痛和成瘾治疗的进展。特别是现在，随着鸦片类药物的流行，至关重要的是我们 保持我们了解阿片类药物滥用背后的生物学和开发新的治疗药物的势头。在……里面 此外，INRC是培养年轻、少数民族和女性科学家进入阿片类药物的重要论坛 研究领域，发扬高质量尖端科学的传统。这份申请旨在提前 这些目标是为即将举行的2020-2024年INRC会议提供支持。大部分资金将用于 用于财政援助，允许初级、少数民族和女性科学家参加和参与 会议。一小部分将用于支付受邀的全体会议和研讨会演讲者的费用，这些演讲者不 通常进行药物滥用研究，但在以下方面提供新的展望和/或发现 药物滥用研究，并支持举办会议的一小部分行政费用。 这项多年拨款将改变重点，突出基础科学中的特定主题。 并通过提供连续性，将培养早期职业调查人员成熟到未来 培养一代药物滥用研究人员，并将他们培养成该领域的领导者。

Abstract The International Narcotics Research Conference (INRC) is the world’s foremost organization of scientists dedicated to the study of opioids. Research into narcotics and addiction is moving rapidly with groundbreaking new techniques in neuroscience and in the structural biology of receptors. The INRC meets each year and is the premier meeting for dissemination and coordination of this important and innovative information. At the INRC meeting the most recent research is presented describing advances in the area of endogenous opioids, opioid receptors, opiate drug pharmacology, opiate tolerance, dependence and addiction and cross-talk with other neurotransmitter systems, especially since the opioid system has been recognized as central to addiction to a variety of substances. This basic science is necessary to pave the way for translation into clinical advances in pain and addiction treatment. Particularly now, with an opiate epidemic, it is crucial that we maintain our momentum to understand the biology behind opioid abuse and develop novel treatment agents. In addition, INRC is an essential forum to develop younger, minority and women scientists to enter the opioid research field and carry on the tradition of high-quality cutting-edge science. This application seeks to advance these aims by providing support for five upcoming INRC meetings, 2020-2024. The majority of the funds will be used for financial assistance to allow junior, minority and women scientists to attend and participate in the conference. A smaller portion will help defray the cost of invited plenary and symposium speakers who do not normally conduct drug abuse research, but provide a fresh outlook and/or findings in areas complementary to drug abuse research, and also support a small portion of the administrative costs of running the conference. This multi-year grant will provide for a changing emphasis to highlight specific themes in the basic science of addiction and, by providing continuity, will nurture early career investigators to mature into the future generation of drug abuse researchers and develop them to be leaders in the field.