51st to 55th ANNUAL INTERNATIONAL NARCOTICS RESEARCHCONFERENCES

摘要 国际麻醉品研究会议 (INRC) 是世界上最重要的科学家组织 致力于阿片类药物的研究。对麻醉品和成瘾的研究正在迅速发展并具有突破性 神经科学和受体结构生物学的新技术。 INRC 每年召开一次会议， 传播和协调这一重要和创新信息的首要会议。在 INRC 会议提出了最新的研究，描述了内源性阿片类药物领域的进展， 阿片受体、阿片类药物药理学、阿片类药物耐受性、依赖性和成瘾性以及与阿片类药物的交叉对话 其他神经递质系统，特别是阿片类药物系统已被认为是成瘾的核心 到多种物质。这一基础科学对于转化为临床铺平道路是必要的 疼痛和成瘾治疗方面的进展。特别是现在，阿片类药物泛滥，我们必须 保持我们了解阿片类药物滥用背后的生物学并开发新型治疗药物的动力。在 此外，INRC 是培养年轻、少数族裔和女性科学家进入阿片类药物领域的重要论坛 研究领域并继承高质量尖端科学的传统。该应用程序旨在推进 通过为即将举行的 2020-2024 年五次 INRC 会议提供支持来实现这些目标。大部分资金将 用于财政援助，让初级科学家、少数族裔科学家和女科学家能够出席和参与 会议。较小的一部分将有助于支付不参加会议的受邀全体会议和研讨会发言人的费用 通常进行药物滥用研究，但在补充领域提供新的前景和/或发现 药物滥用研究，并且还支持举办会议的一小部分行政费用。 这项多年期资助将改变重点，以突出基础科学中的特定主题 成瘾，并通过提供连续性，将培养早期职业调查员走向成熟 一代药物滥用研究人员，并将他们培养成为该领域的领导者。

Abstract The International Narcotics Research Conference (INRC) is the world’s foremost organization of scientists dedicated to the study of opioids. Research into narcotics and addiction is moving rapidly with groundbreaking new techniques in neuroscience and in the structural biology of receptors. The INRC meets each year and is the premier meeting for dissemination and coordination of this important and innovative information. At the INRC meeting the most recent research is presented describing advances in the area of endogenous opioids, opioid receptors, opiate drug pharmacology, opiate tolerance, dependence and addiction and cross-talk with other neurotransmitter systems, especially since the opioid system has been recognized as central to addiction to a variety of substances. This basic science is necessary to pave the way for translation into clinical advances in pain and addiction treatment. Particularly now, with an opiate epidemic, it is crucial that we maintain our momentum to understand the biology behind opioid abuse and develop novel treatment agents. In addition, INRC is an essential forum to develop younger, minority and women scientists to enter the opioid research field and carry on the tradition of high-quality cutting-edge science. This application seeks to advance these aims by providing support for five upcoming INRC meetings, 2020-2024. The majority of the funds will be used for financial assistance to allow junior, minority and women scientists to attend and participate in the conference. A smaller portion will help defray the cost of invited plenary and symposium speakers who do not normally conduct drug abuse research, but provide a fresh outlook and/or findings in areas complementary to drug abuse research, and also support a small portion of the administrative costs of running the conference. This multi-year grant will provide for a changing emphasis to highlight specific themes in the basic science of addiction and, by providing continuity, will nurture early career investigators to mature into the future generation of drug abuse researchers and develop them to be leaders in the field.