Physical Activity, Sedentary Behavior, and Cancer Incidence in Women
女性的体力活动、久坐行为和癌症发病率
基本信息
- 批准号:10477019
- 负责人:
- 金额:$ 62.46万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-17 至 2025-02-28
- 项目状态:未结题
- 来源:
- 关键词:AccelerometerAddressAgeAge-YearsBehavior TherapyBreastCause of DeathCervicalCessation of lifeChronicCohort StudiesCollectionDataDevelopmentDiagnosisDoseElderlyEventFrequenciesGuidelinesHealthHeart DiseasesHumanIncidenceInterruptionInterventionIntervention StudiesLaboratory StudyLeisuresLightLight ExerciseLongevityMachine LearningMalignant NeoplasmsMeasurementMeasuresMethodologyMethodsMonitorNIH Program AnnouncementsObservational StudyOutcomeOvarianPatient Self-ReportPatternPersonsPhysical activityProspective StudiesPublic HealthRecommendationReportingResearchResearch PersonnelResolutionRespiratory DiseaseRiskRisk FactorsScienceSiteStrokeTimeTranslatingUnited StatesUnited States National Institutes of HealthUterusWalkingWomanWomen&aposs Healthadjudicateage groupanalytical methodbasecancer riskcancer typecohortcomputerized data processingcostcost efficientdisorder preventionfollow-upimprovedindexinginsightmachine learning algorithmmalignant breast neoplasmmenmortalitynovelolder womenresponsesedentarysedentary lifestylesexvigorous intensityyoung adult
项目摘要
Abstract
In the United States in 2016, an estimated 600,000 people will die from cancer and 1.7 million new cases of
cancer will be diagnosed. Considering the life span, almost 40% of women and men will be diagnosed with
cancer at some point in their lifetime. Understanding amenable risk factors that contribute to this large public
health burden is essential. Observational studies consistently indicate associations between self-reported
physical activity and increased risk of many types of cancer, especially breast cancer. However, there is
insufficient evidence regarding the amount, intensity, duration, and types of physical activity required to reduce
cancer risk, especially for older women. Sedentary behavior may provide a more feasible intervention target,
especially for older adults. However, even less is known about sedentary behavior and cancer risk. To date,
no prospective studies have examined accelerometry-derived physical activity and sedentary behavior to risk
of incident cancer outcomes. Advances have been made in new measurement methods by our team, but have
not been applied to health outcomes to assess their value. In this application, we propose to assemble
accelerometry-assessed physical activity and sedentary behavior and cancer incident events and deaths from
two cohort studies of women: the Women's Health Study (WHS) and the Women's Health Initiative (WHI)
Study. We will apply sophisticated, yet directly interpretable, methods to determine which physical activity and
sedentary behavior features are most important for reducing cancer risk among more than 22,000 women 63
to 101 years of age. For both cohorts, one-week of accelerometry data were collected in a similar manner
during 2011-2014. Follow-up of both cohorts for adjudicated cancer outcomes is planned through 2020 and
likely beyond. We propose three aims. Aim 1 will apply novel and translational measures of accelerometry-
assessed physical activity and sedentary behavior using latent class analysis, an activity index, and machine
learning algorithms of raw accelerometry data for use in Aims 2 and 3. We will then investigate the association
of accelerometry-assessed physical activity (Aim 2) and sedentary behavior (Aim 3) to overall and site-specific
(e.g., breast, uterine, ovarian) incident and fatal cancer. This cost-efficient study will investigate in detail
whether and how patterns of frequency, duration, intensity, bouts, and type of physical activity and sedentary
behavior predict cancer outcomes. Identification of new cancer-protective patterns of physical activity and
sedentary behavior will provide much-needed evidence to inform physical activity and sedentary behavior
guidelines for disease prevention, can be used in interventions to reduce risk, and could revolutionize the
monitoring of human responses in physical activity and sedentary behavior interventions.
摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Kelly R. Evenson其他文献
Leisure-Time Physical Activity in Pregnancy and Maternal-Child Health: A Systematic Review and Meta-Analysis of Randomized Controlled Trials and Cohort Studies
- DOI:
10.1007/s40279-016-0565-2 - 发表时间:
2016-06-09 - 期刊:
- 影响因子:9.400
- 作者:
Shana G. da Silva;Luiza I. Ricardo;Kelly R. Evenson;Pedro C. Hallal - 通讯作者:
Pedro C. Hallal
Impact of Park Redesign and Renovation on Children’s Health-Related Quality of Life
公园重新设计和翻新对儿童健康相关生活质量的影响
- DOI:
10.1007/s11524-024-00954-9 - 发表时间:
2025-01-17 - 期刊:
- 影响因子:4.100
- 作者:
Houlin Hong;Hanish P. Kodali;Ann F. Dunlap;Katarzyna E. Wyka;Lorna E. Thorpe;Kelly R. Evenson;Terry T.-K. Huang - 通讯作者:
Terry T.-K. Huang
Daily steps, activity, sedentary and sleep behaviors associations with all-cause mortality: The ELSA-Brasil study
日常步数、活动量、久坐行为及睡眠行为与全因死亡率的关联:巴西成人健康纵向研究(ELSA - Brasil研究)
- DOI:
10.1016/j.ypmed.2025.108241 - 发表时间:
2025-03-01 - 期刊:
- 影响因子:3.200
- 作者:
Danilo de Paula;Kelly R. Evenson;Natan Feter;Rosane Harter Griep;Ciro Oliveira Queiroz;Rodrigo Citton Padilha dos Reis;Bruce Bartholow Duncan;Maria Inês Schmidt - 通讯作者:
Maria Inês Schmidt
Targeting physical activity interventions for adults: When should intervention occur?
- DOI:
10.1016/j.ypmed.2016.12.036 - 发表时间:
2017-04-01 - 期刊:
- 影响因子:
- 作者:
Katelyn M. Holliday;Dan Yu Lin;Sujatro Chakladar;Sheila F. Castañeda;Martha L. Daviglus;Kelly R. Evenson;David X. Marquez;Qibin Qi;Christina M. Shay;Daniela Sotres-Alvarez;Denise C. Vidot;Donglin Zeng;Christy L. Avery - 通讯作者:
Christy L. Avery
The association of physical activity fragmentation with all-cause mortality in Hispanics: a prospective cohort study
西班牙裔人群身体活动碎片化与全因死亡率的关联:一项前瞻性队列研究
- DOI:
10.1016/j.lana.2025.100996 - 发表时间:
2025-02-01 - 期刊:
- 影响因子:7.600
- 作者:
Mauro F.F. Mediano;Yejin Mok;Shoshana H. Ballew;Franklyn Gonzalez;Daniela Sotres-Alvarez;Yasmin Mossavar-Rahmani;Robert Kaplan;Jordan A. Carlson;Sarah K. Alver;Martha Daviglus;Olga Garcia-Bedoya;Kelly R. Evenson;Jennifer A. Schrack;Kunihiro Matsushita - 通讯作者:
Kunihiro Matsushita
Kelly R. Evenson的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Kelly R. Evenson', 18)}}的其他基金
Physical Activity, Sedentary Behavior, and Cancer Incidence in Women
女性的体力活动、久坐行为和癌症发病率
- 批准号:
10246990 - 财政年份:2019
- 资助金额:
$ 62.46万 - 项目类别:
Physical Activity, Sedentary Behavior, and Cancer Incidence in Women
女性的体力活动、久坐行为和癌症发病率
- 批准号:
10524111 - 财政年份:2019
- 资助金额:
$ 62.46万 - 项目类别:
Accelerometry-derived latent class analysis and cancer in the Women's Health Accelerometry Collaboration
女性健康加速测量协作中加速测量衍生的潜在类别分析和癌症
- 批准号:
10378978 - 财政年份:2019
- 资助金额:
$ 62.46万 - 项目类别:
Physical Activity, Sedentary Behavior, and Cancer Incidence in Women
女性的体力活动、久坐行为和癌症发病率
- 批准号:
10019477 - 财政年份:2019
- 资助金额:
$ 62.46万 - 项目类别:
National Associations of Objectively Measured Physical Activity and Mortality
全国客观测量身体活动和死亡率协会
- 批准号:
8352637 - 财政年份:2012
- 资助金额:
$ 62.46万 - 项目类别:
National Associations of Objectively Measured Physical Activity and Mortality
全国客观测量身体活动和死亡率协会
- 批准号:
8487438 - 财政年份:2012
- 资助金额:
$ 62.46万 - 项目类别:
Spousal communication and cancer prevention behavior
配偶沟通与癌症预防行为
- 批准号:
7035312 - 财政年份:2005
- 资助金额:
$ 62.46万 - 项目类别:
Understanding Change in Physical Activity Postpartum
了解产后身体活动的变化
- 批准号:
7647958 - 财政年份:2004
- 资助金额:
$ 62.46万 - 项目类别:
Understanding Change in Physical Activity Postpartum
了解产后身体活动的变化
- 批准号:
6826466 - 财政年份:2004
- 资助金额:
$ 62.46万 - 项目类别:
Understanding Change in Physical Activity Postpartum
了解产后身体活动的变化
- 批准号:
7117603 - 财政年份:2004
- 资助金额:
$ 62.46万 - 项目类别:
相似海外基金
Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
- 批准号:
MR/S03398X/2 - 财政年份:2024
- 资助金额:
$ 62.46万 - 项目类别:
Fellowship
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
- 批准号:
EP/Y001486/1 - 财政年份:2024
- 资助金额:
$ 62.46万 - 项目类别:
Research Grant
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
- 批准号:
2338423 - 财政年份:2024
- 资助金额:
$ 62.46万 - 项目类别:
Continuing Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
- 批准号:
MR/X03657X/1 - 财政年份:2024
- 资助金额:
$ 62.46万 - 项目类别:
Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
- 批准号:
2348066 - 财政年份:2024
- 资助金额:
$ 62.46万 - 项目类别:
Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
- 批准号:
AH/Z505481/1 - 财政年份:2024
- 资助金额:
$ 62.46万 - 项目类别:
Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10107647 - 财政年份:2024
- 资助金额:
$ 62.46万 - 项目类别:
EU-Funded
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
- 批准号:
2341402 - 财政年份:2024
- 资助金额:
$ 62.46万 - 项目类别:
Standard Grant
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10106221 - 财政年份:2024
- 资助金额:
$ 62.46万 - 项目类别:
EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
- 批准号:
AH/Z505341/1 - 财政年份:2024
- 资助金额:
$ 62.46万 - 项目类别:
Research Grant