Emergency COVID-19 Variant Supplement for Atlanta Center for Microsystems Engineered Point-of-Care Technologies (ACME POCT)

亚特兰大微系统工程护理点技术中心 (ACME POCT) 的紧急 COVID-19 变异补充品

• 批准号: 10476947
• 负责人: Wilbur A Lam
• 金额: $ 1548.19万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-18 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10476947
• 关键词: Address; Adoption; Ambulances; Biomedical Engineering; Blood; Cardiac; Cardiology; Cellular Phone; Child health care; Clinical; Clinical Research; Clinical and Translational Science Awards; Clinical assessments; Collaborations; Country; Critical Care; Critical Illness; Data; Development; Device or Instrument Development; Devices; Diagnosis; Diagnostic; Doctor of Philosophy; Electronics; Emergency Situation; Engineering; Equilibrium; Faculty; Fostering; Funding; Future; General Population; Goals; Guidelines; Head; Health Services Research; Heart; Heart Diseases; Heart failure; Hematologist; Hematology; Home; Hospitals; Institutes; International; Leadership; Lung; Lung diseases; Medical Device; Medical Technology; Medicine; Microfluidics; Monitor; Movement; Nanotechnology; National Heart, Lung, and Blood Institute; Organ; Pathologic; Patients; Pediatric Hospitals; Physicians; Physicians' Offices; Play; Point of Care Technology; Process; Pulmonology; Recording of previous events; Role; SARS-CoV-2 variant; Side; Signal Transduction; Sleep; System; Technology; Time; Training Activity; Translations; United States National Institutes of Health; University Hospitals; Validation; base; commercialization; cost; diagnostic value; feasibility testing; health care delivery; innovation; microchip; microsensor; microsystems; novel; operation; point of care; point of care testing; point-of-care diagnostics; portability; programs; prototype; research clinical testing; sensor; sound; success; technology development; technology training; uptake; usability

The advent of point-of-care (POC) diagnostic capabilities has enabled rapid and timely clinical evaluation in the physician's office, an ambulance, the home, the field, or in the hospital and has the potential to significantly impact health care delivery. In cardiology, pulmonology/critical care, and hematology, POC testing plays an especially significant role as the heart and lungs are among the most vital of organs necessitating real time diagnosis and rapid management during critical illnesses, while pathologic alternations in blood are associated with critical, systemic illness. One class of novel medical technologies that is showing promise for POC applications are microsystems-engineered technologies, that is, microchip-enabled devices ranging from microelectromechanical systems (MEMs)-based sensors, microfluidics, to even smartphone-based systems. Notable for their small size and power requirements, microchip-based systems provide the portability that is vital for POC testing. In addition, the capability of microsystems to convert sound and movement into electrical signals enable these technologies to be ideal devices to sense the dynamics of the lungs and heart and therefore to diagnose and monitor pulmonary and cardiac disorders. Moreover, microsystems engineering has brought forth the field of microfluidics, which is steadily finding applications for blood-based diagnostics, and therefore, hematologic applications. To that end, per the NHLBI's U54 POCTRN guidelines, the overall goal of the Atlanta Center for Microsystems Engineered POC Technologies (ACME POCT) is to assist and enable inventors from across the country who have developed microsystems-based POC technologies for cardiac, pulmonary, hematologic and sleep applications that are beyond proof-of-concept to define their specific clinical needs, conduct clinical validation, and refine their technology, with the objective of accelerating the path to translation and clinical adoption and directly addressing the barriers thereof. The ACME POCT uniquely leverages Atlanta's nationally top-ranked clinical programs at Emory University's hospitals and Children's Healthcare of Atlanta, one of the nation's largest pediatric hospital systems, as well the internationally acclaimed microsystems engineering expertise at Georgia Tech, which includes the Institute for Electronics and Nanotechnology (IEN), and other one-of-a-kind medical device prototyping, innovation, and testbed facilities. The ACME POCT PI's uniquely balance the engineering and clinical sides of the Center and comprise Wilbur Lam, MD, PhD, a clinical hematologist at Emory and Georgia Tech bioengineer with expertise in POC diagnostic development and commercialization, Oliver Brand, PhD, a renowned microsystems engineer and head of Georgia Tech's IEN, and Greg Martin, MD, MSc, a clinical pulmonologist at Emory and head of clinical research in Atlanta's NIH-funded CTSA. Importantly, the leadership of the ACME POCT has a history of collaboration and track record in managing Centers that have fostered medical device development.

护理点(POC)诊断功能的出现使快速和及时的临床评估成为可能 医生的办公室、救护车、家庭、现场或医院，并且有可能显著 影响医疗服务的提供。在心脏病学、肺病学/重症监护和血液学中，POC检测发挥着重要作用 心脏和肺是最重要的器官之一，需要实时 在危重疾病期间的诊断和快速处理，同时血液中的病理变化与 患有严重的系统性疾病。一类显示出PoC前景的新型医疗技术 应用是微系统工程技术，即支持微芯片的设备，范围从 基于微电子机械系统(MEMS)的传感器、微流体，甚至基于智能手机的系统。 基于微芯片的系统以其体积小和功耗要求而闻名，它提供了 对于PoC测试至关重要。此外，微系统将声音和运动转换为电能的能力 信号使这些技术成为感知肺和心脏动态的理想设备，并 因此，诊断和监测肺和心脏疾病。此外，微系统工程已经 带来了微流体领域，这一领域正在稳步找到基于血液的诊断的应用，以及 因此，血液学的应用。为此，根据NHLBI的U54 POCTRN指南， 亚特兰大微系统工程POC技术中心(ACME POCT)将协助和启用 来自全国各地的发明家，他们开发了基于微系统的心脏POC技术， 肺、血液学和睡眠应用超出概念验证以定义其特定的临床应用 需求，进行临床验证，并改进他们的技术，目标是加速实现 翻译和临床采用，并直接解决其障碍。ACME的观点是唯一的 利用亚特兰大埃默里大学医院和儿童医院的全国一流临床项目 亚特兰大的医疗保健，美国最大的儿科医院系统之一，以及国际 佐治亚理工学院广受赞誉的微系统工程专业知识，其中包括电子研究所 和纳米技术(Ien)，以及其他独一无二的医疗设备原型、创新和试验台 设施。ACME POCT PI独一无二地平衡了中心的工程和临床方面，并 包括Wilbur Lam，医学博士，Emory的临床血液学家和佐治亚理工学院的具有专业知识的生物工程师 在PoC诊断开发和商业化方面，著名的微系统公司Oliver Brand，PhD 乔治亚理工学院的工程师兼负责人格雷格·马丁，医学博士，硕士，埃默里大学和 亚特兰大国立卫生研究院资助的CTSA的临床研究负责人。重要的是，ACME POCT的领导层有一个 在管理促进医疗器械开发的中心方面的合作历史和跟踪记录。